Laparoscopic Liver Surgery: What Are the Advantages in Patients with Cirrhosis and Portal Hypertension? Systematic Review and Meta-Analysis with Personal Experience

2020 ◽  
Vol 30 (10) ◽  
pp. 1054-1065
Author(s):  
Diego Coletta ◽  
Cristina De Padua ◽  
Chiara Parrino ◽  
Valerio De Peppo ◽  
Andrea Oddi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Portal Hypertension ◽  
Liver Surgery ◽  
Personal Experience ◽  
Meta Analysis ◽  
Laparoscopic Liver Surgery

scholarly journals von Willebrand factor as a biomarker of clinically significant portal hypertension and severe portal hypertension: a systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e025656
Author(s):  
Ziyuan Zou ◽  
Xinwen Yan ◽  
Cheng Li ◽  
Xiaofeng Li ◽  
Xiaofen Ma ◽  
...  
Keyword(s):  
Systematic Review ◽  
Portal Hypertension ◽  
Correlation Coefficient ◽  
Von Willebrand Factor ◽  
Diagnostic Performance ◽  
Meta Analysis ◽  
Moderate Correlation ◽  
Clinically Significant ◽  
Von Willebrand ◽  
Willebrand Factor

ObjectiveThis meta-analysis was performed to investigate the correlation between von Willebrand factor (vWF) antigen and hepatic venous pressure gradient (HVPG) and to evaluate the diagnostic performance of vWF to detect clinically significant portal hypertension (CSPH) and severe portal hypertension (SPH).DesignSystematic review and meta-analysis.MethodsMEDLINE, EMBASE, Web of Science and the Cochrane Library were screened up to 5 April 2018. Studies related to the diagnostic performance of vWF to detect CSPH and/or SPH with HVPG as the reference standard were included. Study quality was assessed by using the Quality Assessment of Diagnostic Accuracy Studies scale. Two authors independently used a standardised form to extract data.OutcomesThe primary outcome was the correlation coefficient between vWF and HVPG. The secondary outcome was the diagnostic performance of vWF to detect CSPH or SPH.ResultsA total of six articles involving 994 patients were included in this study. Five of the included articles were used to stratify the results for the correlation coefficient, three for the diagnostic performance of CSPH and two for SPH. The pooled correlation coefficient based on the random effects model was 0.54 (95% CI 0.35 to 0.69), thus suggesting a moderate correlation between vWF and HVPG. The pooled sensitivity, specificity and area under the curve of vWF for CSPH detection were 82% (95% CI 78 to 86), 76% (95% CI 68 to 83) and 0.87 (95% CI 0.80 to 0.94), respectively. Regarding the ability of vWF to detect SPH, the pooled sensitivity and specificity were 86% (95% CI 80 to 90) and 75% (95% CI 66 to 83), respectively. These results supported the satisfactory diagnostic performance of vWF for CSPH and SPH detection.ConclusionsvWF, as a novel biomarker, has a moderate correlation with HVPG and shows a satisfactory performance for the diagnosis of CSPH and SPH in patients with cirrhosis.

The Volume Effect in Liver Surgery—A Systematic Review and Meta-analysis

2013 ◽  
Vol 17 (11) ◽  
pp. 1984-1996 ◽  
Author(s):  
Arthur J. Richardson ◽  
Tony C. Y. Pang ◽  
Emma Johnston ◽  
Michael J. Hollands ◽  
Vincent W. T. Lam ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Surgery ◽  
Meta Analysis ◽  
Volume Effect

Shear Wave Elastography as a Quantitative Biomarker of Clinically Significant Portal Hypertension: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 210 (5) ◽  
pp. W185-W195 ◽  
Author(s):  
Chong Hyun Suh ◽  
Kyung Won Kim ◽  
Seong Ho Park ◽  
Seung Soo Lee ◽  
Ho Sung Kim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Portal Hypertension ◽  
Shear Wave ◽  
Meta Analysis ◽  
Shear Wave Elastography ◽  
Clinically Significant
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