Short-Term and Long-Term Outcomes of Laparoscopic Versus Open Surgery for Low Rectal Cancer

2018 ◽  
Vol 28 (6) ◽  
pp. 637-644 ◽  
Author(s):  
Qing-Bin Wu ◽  
Xiang-Bing Deng ◽  
Xu-Bing Zhang ◽  
Ling-Hong Kong ◽  
Zong-Guang Zhou ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Open Surgery ◽  
Low Rectal Cancer ◽  
Long Term Outcomes ◽  
Short Term

Short-term and Long-term Outcomes Regarding Laparoscopic Versus Open Surgery for Low Rectal Cancer

2015 ◽  
Vol 25 (4) ◽  
pp. 286-296 ◽  
Author(s):  
Jin-bo Jiang ◽  
Kun Jiang ◽  
Jing-jing Wang ◽  
Yong Dai ◽  
Fu-bo Xie ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Open Surgery ◽  
Low Rectal Cancer ◽  
Long Term Outcomes ◽  
Short Term

Comparison of long-term survival outcomes between laparoscopic and open surgery for mid or low rectal cancer treated with preoperative chemoradiotherapy: 7-year follow-up of COREAN trial.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3518-3518
Author(s):  
Ji Won Park ◽  
Seung-Yong Jeong ◽  
Sung-Bum Kang ◽  
Jungnam Joo ◽  
Mi Kyung Song ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Laparoscopic Surgery ◽  
Local Recurrence ◽  
Open Surgery ◽  
Disease Free Survival ◽  
Preoperative Chemoradiotherapy ◽  
Low Rectal Cancer ◽  
Free Survival ◽  
Disease Free

3518 Background: Laparoscopic surgery for rectal cancer has been used widely. However, recent two randomized trials raised concerns about short-term oncologic safety of laparoscopic surgery for rectal cancer. The aim of this study was to evaluate the long-term oncologic safety of laparoscopic surgery for rectal cancer based on 7-year data from the Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial. Methods: COREAN trial was a non-inferiority, randomized controlled trial. Between April, 2006, and Aug, 2009, eligible participants with mid or low rectal cancer treated with preoperative chemoradiotherapy were randomly assigned (1:1) to laparoscopic (n = 170) or open surgery (n = 170). Seven-year outcomes included overall and disease-free survival, and local recurrence. Log-rank test and stratified Cox regression analysis were used for survival analysis. Analysis was by intention to treat. Results: The median follow-up times were 84 months (IQR: 61.5-97.0). No differences were found between laparoscopic and open surgery group in terms of overall and disease-free survival, and local recurrence (7-year overall survival: 83.2% [laparoscopic] vs 77.3% [open], p = 0.48; 7-year disease-free survival: 71.6% [laparoscopic] vs 64.3% [open], p = 0.20; 7-year local recurrence: 3.3% [laparoscopic] vs 7.9% [open], p = 0.08). Stratified Cox regression analysis adjusted for ypT, ypN and tumor regression grade showed no significant difference between groups in terms of overall and disease-free survival, and local recurrence. The hazard ratios for overall survival, disease-free survival and local recurrence (open vs laparoscopic surgery) were 0.96 (95% CI = 0.58-1.57), 1.03 (95% CI = 0.70-1.53), and 2.28 (95% CI = 0.82-7.16), respectively. Conclusions: The 7-year analysis confirm the long-term oncological safety of laparoscopic surgery for rectal cancer treated with preoperative chemoradiotherapy. The use of laparoscopic surgery does not compromise the long-term survival outcomes in rectal cancer. Clinical trial information: NCT00470951.

Long-Term Outcomes of Patients Undergoing Curative Laparoscopic Surgery for Mid and Low Rectal Cancer

2009 ◽  
Vol 52 (7) ◽  
pp. 1215-1222 ◽  
Author(s):  
Jeffrey W. Milsom ◽  
Olival de Oliveira ◽  
Koiana I. Trencheva ◽  
Sushil Pandey ◽  
Sang W. Lee ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Laparoscopic Surgery ◽  
Low Rectal Cancer ◽  
Long Term Outcomes
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