Initial Report of Sentinel Lymph Node Identification During Laparoscopic Radical Hysterectomy Using a New Gamma Probe Technology

2018 ◽  
Vol 28 (7) ◽  
pp. 864-866
Author(s):  
Shinichi Togami ◽  
Toshihiko Kawamura ◽  
Mika Fukuda ◽  
Shintaro Yanazume ◽  
Masaki Kamio ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radical Hysterectomy ◽  
Gamma Probe ◽  
Initial Report ◽  
Laparoscopic Radical Hysterectomy ◽  
Sentinel Lymph Node Identification

Sentinel Lymph Node Identification and Radical Hysterectomy with Lymphadenectomy in Early Stage Cervical Cancer: Laparoscopy Versus Laparotomy

2008 ◽  
Vol 15 (5) ◽  
pp. 531-537 ◽  
Author(s):  
Berta Díaz-Feijoo ◽  
Antonio Gil-Moreno ◽  
María A. Pérez-Benavente ◽  
Sergio Morchón ◽  
José M. Martínez-Palones ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Radical Hysterectomy ◽  
Early Stage ◽  
Sentinel Lymph Node Identification ◽  
Early Stage Cervical Cancer ◽  
Cancer Laparoscopy

The Sentinel Lymph Node Concept in Prostate Cancer – First Results of Gamma Probe-Guided Sentinel Lymph Node Identification

1999 ◽  
Vol 36 (6) ◽  
pp. 595-600 ◽  
Author(s):  
Friedhelm Wawroschek ◽  
Harry Vogt ◽  
Dorothea Weckermann ◽  
Theodor Wagner ◽  
Rolf Harzmann
Keyword(s):  
Prostate Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Probe ◽  
Sentinel Lymph Node Identification ◽  
First Results ◽  
Sentinel Lymph Node Concept

scholarly journals Hemosiderin: a new marker for sentinel lymph node identification

2009 ◽  
Vol 24 (6) ◽  
pp. 432-436 ◽  
Author(s):  
Luiz Gonzaga Porto Pinheiro ◽  
Renato Santos de Oliveira Filho ◽  
Paulo Henrique Diógenes Vasques ◽  
Pedro Henrique de Oliveira Filgueira ◽  
Douglas Henning Pinheiro Aragão ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Breast Biopsy ◽  
Gamma Probe ◽  
Sentinel Lymph Nodes ◽  
Patent Blue ◽  
Sentinel Lymph Node Identification ◽  
Lymphatic Duct ◽  
The Right

PURPOSE: To evaluate and present our initial results of a new marker (hemosiderin) for mammary sentinel lymph node identification in an experimental model. METHODS: Skins mapped like a lymphatic duct draining to the axilla in patients submitted to breast biopsy, in our mastology service, stimulated us to try it in an animal model (female dogs). Our theory was that some blood derivate (hemosiderin) was captured by macrophages and accessed the lymphatic ducts in direction to the axilla. Six female dogs of no defined race were studied. We injected 0,2 ml of technetium on both superior mammary glands. After ten minutes, a 2,5 ml solution of hemolized blood (hemosiderin) from the own animal was injected in the subareolar lymphatic plexus on the left superior mammary gland and 2,5 ml of patent blue concomitantly and equally on the contralateral gland. Ten minutes after, incisions on both axilas were made to search, through the lymphatic mapping and a gamma probe, the sentinel lymph nodes. RESULTS: Seven brown sentinel lymph nodes were indentified and also radiomarked on the left axilla. Six blue sentinel lymph nodes were identified and also radiomarked on the right axilla. CONCLUSION: Preliminary studies of a potential new dye for sentinel lymph node identification are presented. It may be the change of the current use of the blue dyes and their severe side-effects on patients submitted to sentinel lymph node biopsies.

First experiences with a new radiopharmaceutical for sentinel lymph node detection in malignant melanoma

2004 ◽  
Vol 43 (01) ◽  
pp. 10-15 ◽  
Author(s):  
R. A. Schmid ◽  
C. Kunte ◽  
B. Konz ◽  
K. Hahn ◽  
M. Weiss
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Malignant Melanoma ◽  
Sentinel Node ◽  
Gamma Probe ◽  
Blue Dye ◽  
Sentinel Nodes ◽  
Technetium 99M ◽  
Positive Rate ◽  
Metastatic Involvement

Summary Aim of this study was to localize the sentinel lymph node by lymphoscintigraphy using technetium-99m colloidal rhenium sulphide (Nanocis®), a new commercially available radiopharmaceutical. Due to the manufacturers’ instructions it is licensed for lymphoscintigraphy. Patients, methods: 35 consecutive patients with histologically proved malignant melanoma, but without clinical evidence of metastases, were preoperatively examined by injecting 20-40 MBq Nanocis® with (mean particle size: 100 nm; range: 50-200 nm) intradermally around the lesion. Additionally blue dye was injected intaoperatively. A hand-held gamma probe guided sentinel node biopsy. Results: During surgery, the preoperatively scintigraphically detected sentinel lymph nodes were identified in 34/35 (97%) patients. The number of sentinel nodes per patient ranged from one to four (mean: n = 1.8). Histologically, metastatic involvement of the sentinel lymph node was found in 12/35 (34%) patients; the sentinel lymph node positive-rate (14/63 SLN) was 22%. Thus, it is comparable to the findings of SLN-mapping using other technetium-99m-labeled nanocolloides. Conclusion: 99mTc-bound colloidal rhenium sulphide is also suitable for sentinel node mapping.

scholarly journals Development and characterization of an all-in-one gamma probe with auto-peak detection for sentinel lymph node biopsy based on NEMA NU3-2004 standard

2021 ◽  
Author(s):  
Aram Radnia ◽  
Hamed Abdollahzadeh ◽  
Behnoosh Teimourian ◽  
Mohammad Hossein Farahani ◽  
Mohammad Esmaeil Akbari ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Gamma Probe ◽  
Peak Detection ◽  
Cesium Iodide ◽  
Shielding Effectiveness ◽  
Scattering Medium ◽  
Silicon Photomultiplier ◽  
Regional Lymph Nodes ◽  
Handheld Device

Abstract Background A gamma probe is a handheld device used for intraoperative interventions following interstitial injection of a radiotracer to locate regional lymph nodes through the external detection of radiation. This work reports on the design and performance evaluation of a novel fully integrated gamma probe (GammaPen), recently developed by our group. Materials and methods GammaPen is an all-in-one pocket gamma probe with low weight and adequate dimensions, consisting of a detector, a control unit and output all together. The detector module consists of a cylindrical Thallium-activated Cesium Iodide [CsI (Tl)] crystal optically coupled to a Silicon photomultiplier (SiPM), shielded using Tungsten housing on side and back faces. The electronics of the probe consists of two small boards to handle signal processing and analog peak detection tasks. A number of parameters, including probe sensitivity in air/water, spatial resolution in air/water, angular resolution in air/water, and side and back shielding effectiveness, were measured to evaluate the performance of the probe based on NEMA NU3-2004 standards. Results The sensitivity of the probe in air at distances of 10, 30, and 50 mm is 18784, 3500, and 1575 cps/MBq. The sensitivity in scattering medium was also measured at distances of 10, 30, and 50 mm as 17,680, 3050, and 1104 cps/MBq. The spatial and angular resolutions in scattering medium were 47 mm and 87 degree at 30 mm distance from the probe, while they were 40 mm and 77 degree in air. The detector shielding effectiveness and leakage sensitivity are 99.91% and 0.09%, respectively. Conclusion The performance characterization showed that GammaPen can be used effectively for sentinel lymph node localization. The probe was successfully used in several surgical interventions by an experienced surgeon confirming its suitability in a clinical setting.

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