Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research

2012 ◽  
Vol 21 (10) ◽  
pp. 1018-1023 ◽  
Author(s):  
Christine L. Carter ◽  
Eileen M. Resnick ◽  
Monica Mallampalli ◽  
Anna Kalbarczyk
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
Future Research ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

scholarly journals The puzzle of sex, gender and Alzheimer’s disease: Why are women more often affected than men?

2018 ◽  
Vol 14 ◽  
pp. 174550651881799 ◽  
Author(s):  
Melissa K Andrew ◽  
Mary C Tierney
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
Sex And Gender ◽  
Functional Roles ◽  
Dementia Research ◽  
And Gender ◽  
Gender Influences ◽  
Sex And Gender Differences ◽  
Biological Differences

Objective: There are impressive differences in the incidence, prevalence and experience of women and men with Alzheimer’s Disease (AD). Notably, two-thirds of those with AD, the most common form of dementia, are women. Our objective was to provide a literature-based framework to understand these sex and gender differences in AD. Methods: We conducted a narrative review to examine sex and gender influences on AD. Results: We present a framework to understanding why these sex and gender differences exist in AD. This includes the influence of longevity (women live longer than men), biological differences (hormonal differences, epigenetics and frailty), differences in cognitive performance (women and men tend to perform differently on some cognitive tests), and gendered social roles and opportunities (educational and occupational opportunities, functional roles post-retirement). Our review clearly indicates the complex interaction of these sex and gender differences and variability within each. Conclusions: Given these important sex and gender differences in AD, we provide recommendations and steps forward describing how both sex and gender should be considered in dementia diagnosis and management and in the design and implementation of dementia research, including studies of caregiving interventions and models of dementia care.

Sex and gender differences in Alzheimer’s disease: current challenges and implications for clinical practice

2020 ◽  
Vol 27 (6) ◽  
pp. 928-943 ◽  
Author(s):  
M. T. Ferretti ◽  
J. Martinkova ◽  
E. Biskup ◽  
T. Benke ◽  
G. Gialdini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
Clinical Practice ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences

A Scoping Review of Literature on Sex and Gender Differences Among Dementia Spousal Caregivers

2019 ◽  
Vol 59 (6) ◽  
pp. e802-e815 ◽  
Author(s):  
Ifah Arbel ◽  
Kathleen S Bingham ◽  
Deirdre R Dawson
Keyword(s):  
Gender Differences ◽  
Scoping Review ◽  
Policy Development ◽  
Empirical Studies ◽  
Spousal Caregivers ◽  
Future Research ◽  
Sex And Gender ◽  
Cross Sectional ◽  
And Gender ◽  
Sex And Gender Differences

Abstract Background and Objectives Sex and gender differences among dementia spousal caregivers have been investigated, but never systematically reviewed or synthesized. A synthesis of findings can help facilitate specificity in practice and in health policy development. As a first step towards such a synthesis, this scoping review reports the available evidence, identifies research gaps, and suggests possible directions for future research. Research Design and Methods A scoping review methodology was used to identify articles, and to chart and analyze data. Systematic searches for published, empirical studies, with an explicit goal or hypothesis related to sex or gender differences were conducted in seven databases. Results Sixty-one studies met inclusion criteria. Most (n = 45) were quantitative, cross-sectional studies. Caregivers included in the studies were generally 61–70 years old, Caucasian, middle-class, and highly educated. The most extensively investigated differences are: depression, burden, objective physical health, and informal supports. Discussion and Implications This scoping review is the first to summarize and critique the research on sex and gender differences that are specific to dementia spousal caregivers. The review can be used by researchers to make decisions regarding future systematic reviews and primary studies. To further strengthen the evidence base, future studies may benefit from including more caregivers of ethnic minorities, using more qualitative, longitudinal, or experimental designs, and focusing on variables needed to inform caregiving models and theories. Overall, this scoping review contributes to furthering gender-sensitive practices and policies that are better tailored to the specific needs of this population.

scholarly journals Beyond Sex: Gender, LGBTQ, and Alzheimer’s Disease and Related Dementias

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 748-748
Author(s):  
C Elizabeth Shaaban ◽  
Michelle Mielke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gender Differences ◽  
Sex Differences ◽  
Reproductive Tract ◽  
Small Vessel Disease ◽  
Sex And Gender ◽  
Multiple Perspectives ◽  
Subjective Memory ◽  
And Gender

Abstract Sex and gender are important sources of variation in Alzheimer’s disease and related dementias (ADRD) and associated caregiving. Women comprise 2/3 of ADRD cases and the majority of ADRD caregivers. Sex encompasses biological differences due to sex chromosomes, reproductive tract, and hormones, while gender constitutes socioculturally constructed psychosocial aspects of sex. Several lines of research have begun to interrogate sex differences, but less is known about the relation of gender and lesbian, gay, bisexual, transgender, and/or queer (LGBTQ) status with ADRD. In this symposium featuring both trainees and faculty we highlight novel research addressing these factors from multiple perspectives. Two presentations address how psychosocial characteristics and their strengths of association with brain health may vary by gender. C. Elizabeth Shaaban presents analyses testing whether gendered psychosocial factors explain sex differences in white matter hyperintensities, a neuroimaging marker of cerebral small vessel disease and risk factor for ADRD. Justina Avila-Rieger presents results testing region of birth-based spatial patterning of dementia risk among Black men and women. Next, Jason Flatt presents prevalence estimates of subjective memory problems and dementia and describe factors associated with dementia among LGBTQ older adults. Finally, gender may also impact perceptions of individuals with dementia. Shana Stites explores gender differences in AD stigma and discuss implications for who is willing to be an AD caregiver. Michelle Mielke, an expert in sex and gender differences in neurodegenerative and age-associated diseases will facilitate conversation about these results and place them in the context of current sex and gender-based ADRD research.

Sex and Gender Differences

2012 ◽  
Vol 220 (2) ◽  
pp. 57-60 ◽  
Author(s):  
Markus Hausmann ◽  
Barbara Schober
Keyword(s):  
Gender Differences ◽  
Sex And Gender ◽  
And Gender ◽  
Sex And Gender Differences
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