Short-Term Effects of 10% Lidocaine Ointment on Allodynia in Cancer Pain: A Randomized, Double-Blind, Placebo-Controlled Crossover Study

2019 ◽  
Vol 22 (11) ◽  
pp. 1364-1369
Author(s):  
Hideaki Hasuo ◽  
Hiroko Sakuma ◽  
Kazuki Uchitani ◽  
Kenichi Ohue ◽  
Mikihiko Fukunaga
Keyword(s):  
Cancer Pain ◽  
Crossover Study ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Short Term Effects

scholarly journals Acute and Short-term Chronic Testosterone Fluctuation Effects on Glucose Homeostasis, Insulin Sensitivity, and Adiponectin: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

2014 ◽  
Vol 99 (6) ◽  
pp. E1088-E1096 ◽  
Author(s):  
Christian Høst ◽  
Lars C. Gormsen ◽  
David M. Hougaard ◽  
Jens S. Christiansen ◽  
Steen B. Pedersen ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
High Molecular Weight ◽  
Glucose Disposal ◽  
Short Term ◽  
High Molecular Weight Adiponectin ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Total Glucose

Context: Low levels of adiponectin and T in men have been shown to predict development of the metabolic syndrome, but the effects of T on glucose metabolism are incompletely understood and may be influenced either directly or indirectly through changes in body composition or in levels of adiponectin. Objective: The aim of the study was to test whether T exerts its effects on glucose metabolism directly or indirectly. Design, Setting, and Participants: In a randomized, double-blind, placebo-controlled, crossover study, 12 healthy young males were studied on four separate occasions. They received GnRH agonist treatment 1 month before 3 of 4 trial days to induce castrate levels of T. On trial days, T gel containing either high or low physiological T dose or placebo was applied to the body. On a fourth trial day, participants constituted their own eugonadal controls. Intervention: Each study comprised a 5-hour basal period and a 3-hour hyperinsulinemic euglycemic clamp. Main Outcome Measures: We measured the effect of acute T on peripheral glucose disposal, total adiponectin and subforms, and other indices of glucose metabolism. Results: Short-term hypogonadism was associated with increased high molecular weight adiponectin levels (P < .03) and increased oxidative glucose disposal (P = .03) but not total glucose disposal (P = .07). Acute T treatment was an independent suppressor of high molecular weight adiponectin levels (P = .04) but did not affect total glucose disposal (P = .17). Conclusions: These data show that T can act through putative fast nongenomic pathways to affect adiponectin levels in humans. The early hypogonadal state is characterized by a marked shift in fuel oxidation from lipids toward glucose, which may rely partly on buffering capabilities of adiponectin.

Short-term effects of massage with olive oil on the severity of uremic restless legs syndrome: A double-blind placebo-controlled trial

2019 ◽  
Vol 44 ◽  
pp. 261-268 ◽  
Author(s):  
Morteza Nasiri ◽  
Mohammad Abbasi ◽  
Zeynab Yousefi Khosroabadi ◽  
Hossien Saghafi ◽  
Fahimeh Hamzeei ◽  
...  
Keyword(s):  
Olive Oil ◽  
Restless Legs Syndrome ◽  
Controlled Trial ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Restless Legs ◽  
Short Term Effects

Immediate and short-term effects of phototherapy on pain, muscle activity, and joint mobility in women with temporomandibular disorder: a randomized, double-blind, placebo-controlled, clinical trial

2017 ◽  
Vol 40 (19) ◽  
pp. 2318-2324 ◽  
Author(s):  
Carolina Marciela Herpich ◽  
Ernesto Cesar Pinto Leal-Junior ◽  
Cid Andre Fidelis de Paula Gomes ◽  
Igor Phillip dos Santos Gloria ◽  
Ana Paula Amaral ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Muscle Activity ◽  
Temporomandibular Disorder ◽  
Controlled Clinical Trial ◽  
Joint Mobility ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Short Term Effects

scholarly journals Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study

2014 ◽  
Vol 19 (6) ◽  
pp. 933-939 ◽  
Author(s):  
Yasuaki Nakagawa ◽  
Shogo Mukai ◽  
Shigeru Yamada ◽  
Masayuki Matsuoka ◽  
Eri Tarumi ◽  
...  
Keyword(s):  
Knee Osteoarthritis ◽  
Prospective Study ◽  
Short Term ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Short Term Effects
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