Effect of Topical Instillation of Pegaptanib Sodium Upon Inflammatory Corneal Neovascularization in Rabbits

2021 ◽  
Author(s):  
Newton Andrade ◽  
Joao Crispim Ribeiro ◽  
Paulo Mateus Silva ◽  
Domingos Savio ◽  
Francisco Vagnaldo Fechine ◽  
...  
Keyword(s):  
Corneal Neovascularization ◽  
Pegaptanib Sodium

Cytocompatible cerium oxide-mediated antioxidative stress in inhibiting ocular inflammation-associated corneal neovascularization

2019 ◽  
Vol 7 (43) ◽  
pp. 6759-6769 ◽  
Author(s):  
Qianqian Zheng ◽  
Yiming Fang ◽  
Li Zeng ◽  
Xingyi Li ◽  
Hao Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Corneal Neovascularization ◽  
Ocular Inflammation ◽  
Antioxidative Stress

As oxidative stress is involved with inflammation and neovascularization, blocking oxidative stress may be beneficial for reducing inflammation.

Bioadhesive glycosylated Nanoformulations for Extended Trans-Cornea Drug Delivery to Suppress Corneal Neovascularization

2021 ◽  
Author(s):  
Yanlong Zhang ◽  
Yunjian Yu ◽  
Gang Li ◽  
Xinge Zhang ◽  
Zhongming Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Corneal Epithelium ◽  
Corneal Neovascularization ◽  
Ocular Diseases ◽  
Rapid Clearance

Eye-drop formulations as conventional regiments to tackle ocular diseases are far from efficient due to the rapid clearance by eye tears and blockage of corneal epithelium barrier. Here, we describe...

scholarly journals Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 647
Author(s):  
Henry T. Hsueh ◽  
Yoo-Chun Kim ◽  
Ian Pitha ◽  
Matthew D. Shin ◽  
Cynthia A. Berlinicke ◽  
...  
Keyword(s):  
Retinal Ganglion Cells ◽  
Rat Model ◽  
Kinase Inhibitor ◽  
Ganglion Cells ◽  
Corneal Neovascularization ◽  
Therapeutic Effects ◽  
Subconjunctival Injection ◽  
Retinal Ganglion ◽  
Drug Concentrations ◽  
Complementary Strategy

Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration of retinal ganglion cells (RGCs) may continue to progress despite extensive lowering of IOP. A complementary strategy to IOP reduction is the use of neuroprotective agents that interrupt the process of cell death by mechanisms independent of IOP. Here, we describe an ion complexation approach for formulating microcrystals containing ~50% loading of a protein kinase inhibitor, sunitinib, to enhance survival of RGCs with subconjunctival injection. A single subconjunctival injection of sunitinib-pamoate complex (SPC) microcrystals provided 20 weeks of sustained retina drug levels, leading to neuroprotection in a rat model of optic nerve injury. Furthermore, subconjunctival injection of SPC microcrystals also led to therapeutic effects in a rat model of corneal neovascularization. Importantly, therapeutically relevant retina drug concentrations were achieved with subconjunctival injection of SPC microcrystals in pigs. For a chronic disease such as glaucoma, a formulation that provides sustained therapeutic effects to complement IOP lowering therapies could provide improved disease management and promote patient quality of life.

Suppression of Corneal Neovascularization by PEDF Release from Human Amniotic Membranes

2004 ◽  
Vol 45 (6) ◽  
pp. 1758 ◽  
Author(s):  
Chunkui Shao ◽  
Jing Sima ◽  
Sarah X. Zhang ◽  
Ji Jin ◽  
Peter Reinach ◽  
...  
Keyword(s):  
Corneal Neovascularization ◽  
Amniotic Membranes

Limbal Stem Cell Deficiency and Corneal Neovascularization

2009 ◽  
Vol 24 (3) ◽  
pp. 139-148 ◽  
Author(s):  
Pauline Lim ◽  
Thomas A. Fuchsluger ◽  
Ula V. Jurkunas
Keyword(s):  
Stem Cell ◽  
Corneal Neovascularization ◽  
Limbal Stem Cell Deficiency ◽  
Limbal Stem Cell

Inhibition of Corneal Neovascularization by Topical Bevacizumab (Anti-VEGF) and Sunitinib (Anti-VEGF and Anti-PDGF) in an Animal Model

2010 ◽  
Vol 150 (4) ◽  
pp. 519-528.e1 ◽  
Author(s):  
Juan J. Pérez-Santonja ◽  
Ezequiel Campos-Mollo ◽  
Mariola Lledó-Riquelme ◽  
Jaime Javaloy ◽  
Jorge L. Alió
Keyword(s):  
Animal Model ◽  
Corneal Neovascularization ◽  
Anti Vegf
Sign in / Sign up

Export Citation Format

Share Document