scholarly journals Is the Eye an Extension of the Brain in Central Nervous System Disease?

2018 ◽  
Vol 34 (1-2) ◽  
pp. 129-133 ◽  
Author(s):  
Lies De Groef ◽  
Maria Francesca Cordeiro
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease ◽  
The Brain

scholarly journals Immune Response-Mediated Protection of Adult but Not Neonatal Mice from Neuron-Restricted Measles Virus Infection and Central Nervous System Disease

1999 ◽  
Vol 73 (3) ◽  
pp. 1795-1801 ◽  
Author(s):  
Diane M. P. Lawrence ◽  
Melinda M. Vaughn ◽  
Alec R. Belman ◽  
Joan S. Cole ◽  
Glenn F. Rall
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Neurological Disease ◽  
Measles Virus ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Antiviral Immune Response ◽  
System Disease ◽  
The Brain

ABSTRACT In many cases of neurological disease associated with viral infection, such as measles virus (MV)-induced subacute sclerosing panencephalitis in children, it is unclear whether the virus or the antiviral immune response within the brain is the cause of disease. MV inoculation of transgenic mice expressing the human MV receptor, CD46, exclusively in neurons resulted in neuronal infection and fatal encephalitis within 2 weeks in neonates, while mice older than 3 weeks of age were resistant to both infection and disease. At all ages, T lymphocytes infiltrated the brain in response to inoculation. To determine the role of lymphocytes in disease progression, CD46+ mice were back-crossed to T- and B-cell-deficient RAG-2 knockout mice. The lymphocyte deficiency did not affect the outcome of disease in neonates, but adult CD46+RAG-2− mice were much more susceptible to both neuronal infection and central nervous system disease than their immunocompetent littermates. These results indicate that CD46-dependent MV infection of neurons, rather than the antiviral immune response in the brain, produces neurological disease in this model system and that immunocompetent adult mice, but not immunologically compromised or immature mice, are protected from infection.

Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease — Six States, 2013–2015

2016 ◽  
Vol 65 (35) ◽  
pp. 930-933 ◽  
Author(s):  
Anita D. Sircar ◽  
Francisca Abanyie ◽  
Dean Blumberg ◽  
Peter Chin-Hong ◽  
Katrina S. Coulter ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Ocular Disease ◽  
Nervous System Disease ◽  
System Disease

scholarly journals Emerging Pharmacological Treatments for Cerebral Edema: Evidence from Clinical Studies

2020 ◽  
Vol 60 (1) ◽  
pp. 291-309 ◽  
Author(s):  
Jesse A. Stokum ◽  
Volodymyr Gerzanich ◽  
Kevin N. Sheth ◽  
W. Taylor Kimberly ◽  
J. Marc Simard
Keyword(s):  
Central Nervous System ◽  
Clinical Trials ◽  
Nervous System ◽  
Cerebral Edema ◽  
Clinical Studies ◽  
Central Nervous System Disease ◽  
Ancient Egypt ◽  
Nervous System Disease ◽  
Pharmacological Treatments ◽  
System Disease

Cerebral edema, a common and often fatal companion to most forms of acute central nervous system disease, has been recognized since the time of ancient Egypt. Unfortunately, our therapeutic armamentarium remains limited, in part due to historic limitations in our understanding of cerebral edema pathophysiology. Recent advancements have led to a number of clinical trials for novel therapeutics that could fundamentally alter the treatment of cerebral edema. In this review, we discuss these agents, their targets, and the data supporting their use, with a focus on agents that have progressed to clinical trials.

Catalytic nanozymes for central nervous system disease

2021 ◽  
Vol 432 ◽  
pp. 213751
Author(s):  
Ke Chen ◽  
Si Sun ◽  
Junying Wang ◽  
Xiao-Dong Zhang
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease

Expanding the central nervous system disease spectrum associated with FLNC mutation

2019 ◽  
Vol 59 (5) ◽  
pp. E33-E37
Author(s):  
Stefano C. Previtali ◽  
Marina Scarlato ◽  
Paolo Vezzulli ◽  
Alessandra Ruggieri ◽  
Daniele Velardo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease ◽  
Disease Spectrum ◽  
The Central Nervous System
Sign in / Sign up

Export Citation Format

Share Document