Rebound Effect After Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Secondary to Central Retinal Vein Occlusion

2012 ◽  
Vol 28 (6) ◽  
pp. 566-568 ◽  
Author(s):  
Maurizio Battaglia Parodi ◽  
Pierluigi Iacono ◽  
Umberto De Benedetto ◽  
Marialucia Cascavilla ◽  
Francesco Bandello
Keyword(s):  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Rebound Effect ◽  
Dexamethasone Implant ◽  
Vein Occlusion ◽  
Intravitreal Dexamethasone Implant ◽  
Intravitreal Dexamethasone ◽  
Central Retinal Vein

scholarly journals Analysis of Morphologic and Functional Outcomes in Macular Edema due to Central Retinal Vein Occlusion Treated with Intravitreal Dexamethasone Implant

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Alfredo Niro ◽  
Giancarlo Sborgia ◽  
Alessandra Sborgia ◽  
Luigi Sborgia ◽  
Claudio Furino ◽  
...  
Keyword(s):  
Macular Edema ◽  
Central Retinal Vein Occlusion ◽  
Functional Outcomes ◽  
Dexamethasone Implant ◽  
Vein Occlusion ◽  
Intravitreal Dexamethasone Implant ◽  
Intravitreal Dexamethasone ◽  
Over Time ◽  
Central Retinal Vein

Purpose. To analyze anatomic and functional retinal changes and their correlation after intravitreal dexamethasone implant (DEX implant) in patients with central retinal vein occlusion- (CRVO-) related macular edema (ME) using optical coherence tomography and microperimetry. Methods. Fifteen treatment-naïve patients with functional impairment due to CRVO-related ME were enrolled in this prospective interventional case series. Main outcomes were best-corrected visual acuity (BCVA), retinal sensitivity (RS), and central retinal thickness (CRT). Secondary outcomes were ellipsoid zone (EZ) status and fixation behaviour. All patients underwent DEX implant and were retreated according to predefined criteria. Data were prospectively recorded at baseline and at month 1, 3, 6, 9, and 12. Correlation between main outcomes was analyzed. Results. Fifteen eyes of 15 patients (9 men, 6 women; mean age 61.8 ± 10.9 years) were included. BCVA and CRT significantly improved at all follow-up visits, while RS significantly improved at 3, 6, 9, and 12 months. EZ status and fixation behaviour did not change significantly. Baseline CRT had a significant negative correlation with BCVA and RS at different follow-up visits (r=−0.52  to −0.63, p≤0.04; r=−0.52, p=0.04; resp.). At all time points, there was not a significant correlation between CRT and BCVA and RS, while RS and BCVA showed a significant correlation, increasing over time (r=−0.72  to −0.89; p<0.001). Conclusion. DEX implant led to a significant morphofunctional improvement. Baseline CRT is predictive of changes of functional outcomes whose correlation increases over time after treatment.

scholarly journals Cataract surgery in a patient with cystic macular edema after central retinal vein occlusion? Combination with intravitreal dexamethasone implant

2012 ◽  
Vol 5 (2) ◽  
pp. 1-4
Author(s):  
Florian Tobias Alwin Kretz ◽  
Gerd Uwe Auffarth
Keyword(s):  
Cataract Surgery ◽  
Macular Edema ◽  
Retinal Vein Occlusion ◽  
Central Retinal Vein Occlusion ◽  
Complete Disappearance ◽  
Visual Rehabilitation ◽  
Vein Occlusion ◽  
Intravitreal Dexamethasone Implant ◽  
Intravitreal Dexamethasone ◽  
Central Retinal Vein

A 77 years old patient presented for cataract surgery. At first visit we found a cataract and hypertensive signs of the fundus. Six month later during pre-surgical examination a cystoid macular edema (CME) caused by central retinal vein occlusion (CRVO) was found. As the cataract had proceeded, we decided to perform a combined surgery with intravitreal application of a dexamethason implant. The biometry of the first visit was used for IOL calculation. The procedure was performed without complications. Pre-surgical BCVA [logMAR] increased from 0.3 to 0.1 ten days after surgery while the central retinal thickness decreased from 586µm to 353µm with a nearly complete disappearance of the CME. Cataract surgery in patients with CME after CRVO can be combined with an intravitreal dexamethason implant and so lead to a good visual rehabilitation. Further studies are needed to give better evidence of the effectivity and to predict the possible treatment duration.

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