Vasodilator Effects of Fasudil, a Rho-Kinase Inhibitor, on Retinal Arterioles in Stroke-Prone Spontaneously Hypertensive Rats

2007 ◽  
Vol 23 (3) ◽  
pp. 207-212 ◽  
Author(s):  
Nami Okamura ◽  
Maki Saito ◽  
Asami Mori ◽  
Kenji Sakamoto ◽  
Sokichi Kametaka ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Retinal Arterioles ◽  
Rho Kinase Inhibitor

Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats

2008 ◽  
Vol 26 (9) ◽  
pp. 1837-1848 ◽  
Author(s):  
Shogo Koshikawa ◽  
Toshio Nishikimi ◽  
Chikako Inaba ◽  
Kazumi Akimoto ◽  
Hiroaki Matsuoka
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Rho Kinase Inhibitor

Protective effect of hydroxyfasudil, a Rho kinase inhibitor, on ventral prostatic hyperplasia in the spontaneously hypertensive rat

The Prostate ◽  
2015 ◽  
Vol 75 (15) ◽  
pp. 1774-1782 ◽  
Author(s):  
Felix Holmström ◽  
Shogo Shimizu ◽  
Takahiro Shimizu ◽  
Youichirou Higashi ◽  
Darryl T. Martin ◽  
...  
Keyword(s):  
Protective Effect ◽  
Kinase Inhibitor ◽  
Spontaneously Hypertensive Rat ◽  
Rho Kinase ◽  
Prostatic Hyperplasia ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat ◽  
Rho Kinase Inhibitor

scholarly journals Identification of Aortic Proteins Involved in Arterial Stiffness in Spontaneously Hypertensive Rats Treated With Perindopril:A Proteomic Approach

2021 ◽  
Vol 12 ◽  
Author(s):  
Danyelle S. Miotto ◽  
Aline Dionizio ◽  
André M. Jacomini ◽  
Anderson S. Zago ◽  
Marília Afonso Rabelo Buzalaf ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Spontaneously Hypertensive Rats ◽  
Wistar Rats ◽  
Molecular Mechanisms ◽  
Rho Kinase ◽  
Vascular Wall ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cytoskeleton Organization ◽  
Proteomic Approach

Arterial stiffness, frequently associated with hypertension, is associated with disorganization of the vascular wall and has been recognized as an independent predictor of all-cause mortality. The identification of the molecular mechanisms involved in aortic stiffness would be an emerging target for hypertension therapeutic intervention. This study evaluated the effects of perindopril on pulse wave velocity (PWV) and on the differentially expressed proteins in aorta of spontaneously hypertensive rats (SHR), using a proteomic approach. SHR and Wistar rats were treated with perindopril (SHRP) or water (SHRc and Wistar rats) for 8 weeks. At the end, SHRC presented higher systolic blood pressure (SBP, +70%) and PWV (+31%) compared with Wistar rats. SHRP had higher values of nitrite concentration and lower PWV compared with SHRC. From 21 upregulated proteins in the aortic wall from SHRC, most of them were involved with the actin cytoskeleton organization, like Tropomyosin and Cofilin-1. After perindopril treatment, there was an upregulation of the GDP dissociation inhibitors (GDIs), which normally inhibits the RhoA/Rho-kinase/cofilin-1 pathway and may contribute to decreased arterial stiffening. In conclusion, the results of the present study revealed that treatment with perindopril reduced SBP and PWV in SHR. In addition, the proteomic analysis in aorta suggested, for the first time, that the RhoA/Rho-kinase/Cofilin-1 pathway may be inhibited by perindopril-induced upregulation of GDIs or increases in NO bioavailability in SHR. Therefore, we may propose that activation of GDIs or inhibition of RhoA/Rho-kinase pathway could be a possible strategy to treat arterial stiffness.

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