Effect of Nitric Oxide Synthesis Inhibition on Post-Occlusive Choroidal Blood Flow in Rats

2000 ◽  
Vol 16 (1) ◽  
pp. 55-64 ◽  
Author(s):  
MICHAEL C. KOSS
Hypertension ◽  
1998 ◽  
Vol 31 (1) ◽  
pp. 315-320 ◽  
Author(s):  
Salah Kassab ◽  
M. Todd Miller ◽  
Robert Hester ◽  
Jacqueline Novak ◽  
Joey P. Granger

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1019-1023 ◽  
Author(s):  
Sofía P. Salas ◽  
Fernando Altermatt ◽  
Mauricio Campos ◽  
Andrea Giacaman ◽  
Pedro Rosso

Neonatology ◽  
2002 ◽  
Vol 82 (3) ◽  
pp. 197-206 ◽  
Author(s):  
Stefan Kutzsche ◽  
Anne-Beate Solas ◽  
Torstein Lyberg ◽  
Ola D. Saugstad

1996 ◽  
Vol 31 (6) ◽  
pp. 800-804 ◽  
Author(s):  
Enrique Grisoni ◽  
Dan Dusleag ◽  
Dennis Super

1993 ◽  
Vol 264 (1) ◽  
pp. F79-F87 ◽  
Author(s):  
D. S. Majid ◽  
A. Williams ◽  
L. G. Navar

Inhibition of nitric oxide (NO) synthesis by intrarenal administration of nitro-L-arginine (NLA) leads to decreases in urinary sodium excretion (UNaV) in association with the increases in renal vascular resistance (RVR). In the present study, we examined the ability of the kidney to alter its sodium excretion in response to acute changes in renal arterial pressure (RAP) in anesthetized dogs before and during intrarenal infusion of NLA (50 micrograms.kg-1.min-1). NO synthesis inhibition in 11 dogs increased RVR by 32 +/- 4% and decreased renal blood flow (RBF) by 25 +/- 3%, outer cortical blood flow by 25 +/- 6%, urine flow by 37 +/- 14%, UNaV by 71 +/- 5%, and fractional excretion of sodium (FENa) by 71 +/- 4%. Glomerular filtration rate was not significantly changed during NLA infusion. As previously reported, there was suppression of the RBF autoregulation plateau during NO synthesis inhibition. In addition, there was a marked attenuation of urine flow and UNaV responses to reductions in RAP (150 to 75 mmHg), with significant reductions in the slopes of the relationships between RAP vs. UNaV and RAP vs. FENa during NLA infusion. Similar responses were observed in nine other dogs treated with the angiotensin receptor antagonist losartan, indicating that an augmented activity of the renin-angiotensin system is not responsible for attenuation of the slope of the pressure-natriuresis relationship during NLA infusion. These data suggest that NO may participate in the mediation of the pressure-natriuresis response.


1995 ◽  
Vol 13 (1) ◽  
pp. 123???128 ◽  
Author(s):  
Antonio Fern??ndez-Rivas ◽  
Joaqu??n Garc??a-Esta?? ◽  
F??lix Vargas

Hypertension ◽  
1994 ◽  
Vol 23 (6_pt_2) ◽  
pp. 971-975 ◽  
Author(s):  
H Matsuoka ◽  
H Nishida ◽  
G Nomura ◽  
B N Van Vliet ◽  
H Toshima

Sign in / Sign up

Export Citation Format

Share Document