Effect of Vigna angularis on High-Fat Diet-Induced Memory and Cognitive Impairments

2020 ◽  
Vol 23 (11) ◽  
pp. 1155-1162
Author(s):  
Ji Myung Choi ◽  
Soo In Lee ◽  
Eun Ju Cho
Keyword(s):  
High Fat Diet ◽  
Cognitive Impairments ◽  
Vigna Angularis ◽  
High Fat

scholarly journals Methionine Restriction Attenuates High-Fat Diet-Induced Gut-Brain Axis Circadian Rhythm Disorders and Cognitive Impairments (P08-052-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Luanfeng Wang ◽  
Bo Ren ◽  
Zhigang Liu ◽  
Xuebo Liu
Keyword(s):  
Metabolic Syndrome ◽  
Circadian Rhythm ◽  
High Fat Diet ◽  
Cognitive Impairments ◽  
High Fat ◽  
Low Fat ◽  
Low Fat Diet ◽  
Methionine Restriction ◽  
Junction Protein ◽  
Circadian Rhythm Disorders

Abstract Objectives Methionine restriction (MR) has emerged as a promising dietary restriction on metabolic syndrome as its beneficial effects on increasing metabolic flexibility and up-regulating mitochondrial function. The circadian clock directs many aspects of metabolism and macronutrients can function as zeitgebers for the clock in a tissue-specific way. It has been demonstrated that high-fat diet could alter daily oscillations via gut-brain axis. We hypothesis that MR is a new strategy could reverse the high-fat diet induced circadian rhythm disorders and cognitive impairments. Methods 3 month-old male C57BL/6 J mice were assigned to four groups based on diet: low-fat diet (0.86% methionine), low-fat diet with MR(0.17% methionine), high-fat diet, and high-fat diet with MR. After 8 weeks treatment, we employed behavioral test, transmission electron microscope, and 16S rDNA sequencing to evaluate cognitive function, rhythmic variation and the interconnection between gut microbiota and central nervous system. Results MR diminished HFD-induced body weight gain and restored the glucose tolerance at ZT0 (light phase) and ZT12 (dark phase). The neuroprotective effects of MR were connected with the ERK/CREB/BDNF signaling pathway and synaptic plasticity. MR changed energy metabolism via activated mTOR/ULK/AMPK signaling in brain. MR ameliorated rhythmic oscillations of clock control gene Bmal1/Per2 in gut-brain axis. Moreover, MR attenuated HFD-induced intestinal inflammatory and protected gut barrier integrity via enhancing the expression of intestinal tight junction protein. The gut microbiome was re-shaped by MR treatment, accompanied by the alteration of short chain fatty acids, the microbial products mediating systemic metabolism and has benefits on brain function. MR increased microbiota-derived butyric and isovaleric which possible synchronizers of peripheral circadian clocks. Conclusions The present study provided comprehensive evidence that MR attenuated obesity-induced cognitive impairment via balancing the circadian rhythm in gut-brain axis and that is a potential new therapeutic avenue for treating metabolic syndrome-related neurodegenerative diseases. Funding Sources This work was financially supported by the National Key Research and Development Program of China, National Natural Science Foundation of China. Supporting Tables, Images and/or Graphs

136. Region-specific differences of high-fat diet induced cognitive impairments between the amygdala and hippocampus

2014 ◽  
Vol 40 ◽  
pp. e39-e40 ◽  
Author(s):  
S.J. Gainey ◽  
K.A. Kwakwa ◽  
J.K. Bray ◽  
M.M. Pillote ◽  
G.G. Freund
Keyword(s):  
High Fat Diet ◽  
Cognitive Impairments ◽  
High Fat

Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice

2017 ◽  
Vol 20 (4) ◽  
pp. 367-375 ◽  
Author(s):  
Jin-Seon Yook ◽  
Kyung-Ah Kim ◽  
Mina Kim ◽  
Youn-Soo Cha
Keyword(s):  
High Fat Diet ◽  
Adzuki Bean ◽  
Vigna Angularis ◽  
High Fat ◽  
Colon Inflammation

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

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