Aronia Berry Extract Ameliorates the Severity of Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice

2017 ◽  
Vol 20 (7) ◽  
pp. 667-675 ◽  
Author(s):  
Sa-Haeng Kang ◽  
Yong-Deok Jeon ◽  
Kwang-Hyun Moon ◽  
Jeong-Ho Lee ◽  
Dae-Geun Kim ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

The Role of SPARC in Human Ulcerative Colitis and Murine Dextran Sodium Sulfate-Induced Colitis

2011 ◽  
Vol 140 (5) ◽  
pp. S-837
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Wataru Aoi ◽  
Ryusuke Horie ◽  
Kazuhiko Uchiyama ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

scholarly journals Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shashank Singh ◽  
Ruchika Bhatia ◽  
Pragyanshu Khare ◽  
Shikha Sharma ◽  
Sivasubramanian Rajarammohan ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Activity Index ◽  
Disease Activity Index ◽  
Dextran Sodium Sulfate ◽  
Raw 264.7 Cells ◽  
Spleen Weight ◽  
Lipocalin 2 ◽  
Weight Percentage ◽  
Microbial Dysbiosis

Abstract Crohn’s and ulcerative colitis are common inflammatory conditions associated with Inflammatory bowel disease. Owing to the importance of diet based approaches for the prevention of inflammatory gut conditions, the present study was aimed to screen the human isolates of Bifidobacterium strains based on their ability to reduce LPS-induced inflammation in murine macrophage (RAW 264.7) cells and to evaluate prioritized strains for their preventive efficacy against ulcerative colitis in mice. Twelve out of 25 isolated strains reduced the production of LPS-induced nitric oxide and inflammatory cytokines. Furthermore, three strains, B. longum Bif10, B. breve Bif11, and B. longum Bif16 conferred protection against dextran sodium sulfate induced colitis in mice. The three strains prevented shortening of colon, spleen weight, percentage body weight change and disease activity index relative to colitis mice. Lower levels of Lipocalin-2, TNF-α, IL-1β and IL-6 and improved SCFA levels were observed in Bifidobacterium supplemented mice relative to DSS counterparts. Bacterial composition of B. longum Bif10 and B. breve Bif11 fed mice was partly similar to the normal mice, while DSS and B. longum Bif16 supplemented mice showed deleterious alterations. At the genus level, Bifidobacterium supplementation inhibited the abundances of pathobionts such as Haemophilus, Klebsiella and Lachnospira there by conferring protection.

Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

2005 ◽  
Vol 50 (5) ◽  
pp. 922-927 ◽  
Author(s):  
Tsunehisa Noto ◽  
Hiroshi Yamada ◽  
Takashi Inui ◽  
Kayoko Okuyama ◽  
Ayako Watanable ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Therapeutic Effects ◽  
Antiulcer Drug ◽  
Ecabet Sodium

Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice

2020 ◽  
Vol 11 (5) ◽  
pp. 4259-4274
Author(s):  
Ruiqiu Zhao ◽  
Yang Ji ◽  
Xin Chen ◽  
Anxiang Su ◽  
Gaoxing Ma ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Gut Microbiota ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Flammulina Velutipes ◽  
Anti Inflammation

Using the Flammulina velutipes polysaccharide (FVP) extracted from our previous study, herein, we investigated the improvement of this β-type glycosidic polysaccharide in alleviating dextran sodium sulfate-induced ulcerative colitis (UC) in mice.

scholarly journals Dietary black raspberries modulate DNA methylation in dextran sodium sulfate (DSS)-induced ulcerative colitis

2013 ◽  
Vol 34 (12) ◽  
pp. 2842-2850 ◽  
Author(s):  
Li-Shu Wang ◽  
Chieh-Ti Kuo ◽  
Kristen Stoner ◽  
Martha Yearsley ◽  
Kiyoko Oshima ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dna Methylation ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate ◽  
Black Raspberries

scholarly journals Intestinal NCoR1 Protects against Dextran Sodium Sulfate‐Induced Ulcerative Colitis

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Shujuan Chen ◽  
Eva Rettenmeier ◽  
Elvira Mennillo ◽  
Chen Chen
Keyword(s):  
Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Dextran Sodium Sulfate

scholarly journals Interleukin-10 is Differentially Expressed in the Small Intestine and the Colon Experiencing Chronic Inflammation and Ulcerative Colitis Induced by Dextran Sodium Sulfate in Young Pigs

2017 ◽  
pp. 147-162 ◽  
Author(s):  
D. LACKEYRAM ◽  
D. YOUNG ◽  
C. J. KIM ◽  
C. YANG ◽  
T. L. ARCHBOLD ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Chronic Inflammation ◽  
Chronic Ulcerative Colitis ◽  
Sodium Sulfate ◽  
Intestinal Inflammation ◽  
Interleukin 10 ◽  
Dextran Sodium Sulfate ◽  
Mrna Abundance ◽  
Control Group ◽  
Young Pigs

Intestinal inflammation induced with dextran sodium sulfate (DSS) is used to study acute or chronic ulcerative colitis in animal models. Decreased gut tissue anti-inflammatory cytokine IL-10 concentration and mRNA abundance are associated with the development of chronic bowel inflammation. Twelve piglets of 3 days old were fitted with an intragastric catheter and randomly allocated into control and DSS groups by administrating either sterile saline or 1.25 g of DSS/kg body weight (BW) in saline per day, respectively, for 10 days. Growth rate and food conversion efficiency were reduced (p<0.05) in the DSS piglets compared with the control group. Quantitative histopathological grading of inflammation in the jejunum and colon collectively showed that the DSS treatment resulted in 12 fold greater (p<0.05) inflammation severity scoring in the colon than in the jejunum, indicative of chronic ulcerative colitis in the colon. Upper gut permeability endpoint was 27.4 fold higher (p<0.05) in the DSS group compared with the control group. The DSS group had higher concentrations and mRNA abundances (p<0.05) of TNF- and IL-6 in the jejunal and colonic tissues compared with the control group. Colonic concentration and mRNA abundance of IL-10 were reduced (p<0.05), however, jejunal IL-10 mRNA abundance was increased (p<0.05) in the DSS group compared with the control group. In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans associated with chronic bowel inflammation.

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