Dietary Supplementation with a Low Dose of Polyphenol-Rich Grape Pomace Extract Prevents Dextran Sulfate Sodium-Induced Colitis in Rats

2016 ◽  
Vol 19 (8) ◽  
pp. 755-758 ◽  
Author(s):  
Ahlem Boussenna ◽  
Juliette Joubert-Zakeyh ◽  
Didier Fraisse ◽  
Bruno Pereira ◽  
Marie-Paule Vasson ◽  
...  
Keyword(s):  
Low Dose ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Dietary Supplementation ◽  
Grape Pomace

Ingestion of Low Dose Pyroglutamyl Leucine Improves Dextran Sulfate Sodium-Induced Colitis and Intestinal Microbiota in Mice

2013 ◽  
Vol 61 (37) ◽  
pp. 8807-8813 ◽  
Author(s):  
Sayori Wada ◽  
Kenji Sato ◽  
Ryoko Ohta ◽  
Eri Wada ◽  
Yukiho Bou ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Low Dose ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium

Polyphenol-rich grape pomace extracts protect against dextran sulfate sodium-induced colitis in rats

2015 ◽  
Vol 96 (4) ◽  
pp. 1260-1268 ◽  
Author(s):  
Ahlem Boussenna ◽  
Juliette Cholet ◽  
Nicolas Goncalves-Mendes ◽  
Juliette Joubert-Zakeyh ◽  
Didier Fraisse ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Grape Pomace

scholarly journals Mitigation of Colonic Inflammation in Dextran Sulfate Sodium-treated Mice by Dietary Supplementation with Soybean Fiber (P06-079-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Joshua Lambert ◽  
Vijaya Indukuri ◽  
Weslie Khoo ◽  
Jose Urena ◽  
Benjamin Chrisfield
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Dietary Supplementation ◽  
Pcr Analysis ◽  
Spleen Weight ◽  
Protective Effects ◽  
Colonic Inflammation ◽  
Markers Of Inflammation ◽  
Gut Barrier Function ◽  
The Impact

Abstract Objectives Soybean fiber (SBF) is an insoluble, but highly fermentable dietary fiber. Previous in vitro fermentation studies with human feces have shown that SBF produces 1.5–8 times more acetate, propionate, and butyrate than oat bran, corn bran, or wheat bran fiber. Short chain fatty acids (SCFA) have been reported to play a key role in maintaining colon health and reducing inflammation. The impact of dietary SBF on colonic inflammation has not previously been examined. Our objective was to determine the anti-inflammatory efficacy of dietary supplementation with SBF in a mouse model of acute colonic inflammation. Methods Male C57BL/6 J mice (5 weeks old) were randomized to AIN93G diet (CTL) or diet where 40% of the fiber was replaced with SBF (SBF-Hi). After 2 weeks of pretreatment, mice were given 2% dextran sulfate sodium (DSS) as the sole source of drinking fluid for 1 week to induce colonic inflammation. During DSS treatment, mice were maintained on their diet treatments. After DSS treatment, mice were euthanized and colonic inflammation was assessed. Results DSS-treated mice had significantly larger spleens and shorter colons than mice treated with water. SBF-Hi mitigated DSS-induced increases in spleen weight (20% lower) and colon shortening (15% longer). Quantitative, reverse transcriptase PCR analysis showed that DSS-treatment increased colonic mRNA expression of interleukin-6 (Il6) and tumor necrosis factor-a (Tnfa) by 3-fold compared to water-treated mice. Dietary supplementation with SBF blunted these increases in Il6 and Tnfa by 87% and 71%, respectively. Conclusions Our results suggest that dietary supplementation with SBF may be a useful approach to mitigate colonic inflammation. On-going studies are focused on determining fecal levels of SCFA and measuring protein markers of inflammation and gut barrier function. Future studies are needed to evaluate whether the protective effects observed in this study are maintained in situations of more chronic colonic inflammation. Funding Sources This work was funded by a grant from the Pennsylvania Soybean Board and by USDA National Institute of Food and Agriculture Appropriations under Project PEN04565.

Low dose cortisone treatment ameliorates dextran sulfate sodium (DSS) induced colitis in mice

2000 ◽  
Vol 118 (4) ◽  
pp. A1332-A1333
Author(s):  
Lars-Gsran Axelsson ◽  
Tryggve Ljung ◽  
Per M. Hellstrsm ◽  
Tore Midtvedt
Keyword(s):  
Low Dose ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium

Shikonin inhibits colitis-associated colorectal dysplasias in a mouse model of azoxymethane/dextran sulfate sodium colitis

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
JL Ríos ◽  
A Martí ◽  
I Andújar ◽  
RM Giner ◽  
MC Recio
Keyword(s):  
Mouse Model ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium

Oral in vivo Bactofection in Dextran Sulfate Sodium Treated Female Wistar Rats

2010 ◽  
Vol 58 (3) ◽  
pp. 171-176 ◽  
Author(s):  
Roland Pálffy ◽  
Michal Behuliak ◽  
Roman Gardlík ◽  
Peter Jáni ◽  
L'udevít Kádaši ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Female Wistar Rats
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