Milk-Derived Peptides, Val-Pro-Pro and Ile-Pro-Pro, Attenuate Atherosclerosis Development in Apolipoprotein E–Deficient Mice: A Preliminary Study

2013 ◽  
Vol 16 (5) ◽  
pp. 396-403 ◽  
Author(s):  
Teppei Nakamura ◽  
Tatsuhiko Hirota ◽  
Katsura Mizushima ◽  
Kohji Ohki ◽  
Yuji Naito ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Preliminary Study ◽  
Atherosclerosis Development ◽  
Deficient Mice

scholarly journals Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids

2017 ◽  
Vol 37 (11) ◽  
pp. 2053-2063 ◽  
Author(s):  
Charlotte Trenteseaux ◽  
Anh-thu Gaston ◽  
Audrey Aguesse ◽  
Guillaume Poupeau ◽  
Pierre de Coppet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Apolipoprotein E ◽  
Bile Acids ◽  
Experimental Studies ◽  
Underlying Mechanism ◽  
Female Offspring ◽  
Promoter Regions ◽  
Maternal Hypercholesterolemia ◽  
Atherosclerosis Development ◽  
Deficient Mice

Objective— Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E–deficient mice and the underlying mechanism. Approach and Results— Atherosclerosis and related parameters were studied in adult male or female apolipoprotein E–deficient mice offspring from either normocholesterolemic or hypercholesterolemic mothers and normocholesterolemic fathers. Female born to hypercholesterolemic mothers had more aortic root lesions than female born to normocholesterolemic mothers. Lesions in whole aorta did not differ between groups. Higher trimethylamine-N-oxide levels and Fmo3 hepatic gene expression were higher in female born to hypercholesterolemic mothers offspring compared with female born to normocholesterolemic mothers and male. Trimethylamine-N-oxide levels were correlated with the size of atherosclerotic root lesions. Levels of hepatic cholesterol and gallbladder bile acid were greater in male born to hypercholesterolemic mothers compared with male born to normocholesterolemic mothers. At 18 weeks of age, female born to hypercholesterolemic mothers showed lower hepatic Scarb1 and Cyp7a1 but higher Nr1h4 gene expression compared with female born to normocholesterolemic mothers. Male born to hypercholesterolemic mothers showed an increase in Scarb1 and Ldlr gene expression compared with male born to normocholesterolemic mothers. At 25 weeks of age, female born to hypercholesterolemic mothers had lower Cyp7a1 gene expression compared with female born to normocholesterolemic mothers. DNA methylation of Fmo3, Scarb1 , and Ldlr promoter regions was slightly modified and may explain the mRNA expression modulation. Conclusions— Our findings suggest that maternal hypercholesterolemia may exacerbate the development of atherosclerosis in female offspring by affecting metabolism of trimethylamine-N-oxide and bile acids. These data could be explained by epigenetic alterations.

Abstract 236: Sirt6 Heterozygosity Exacerbates Atherosclerosis in Apolipoprotein E Deficient Mice

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
De-Pei Liu ◽  
Zhu-Qin Zhang ◽  
Si-Cong Ren ◽  
Zuo-Zhi Li ◽  
Ying Tan ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Apolipoprotein E ◽  
Histone Deacetylase ◽  
Epigenetic Modification ◽  
Atherosclerotic Plaques ◽  
Nkg2d Ligand ◽  
Class Iii ◽  
Ligand Expression ◽  
Atherosclerosis Development ◽  
Deficient Mice

Sirt6 is a member of the class III histone deacetylase family and is reported to promote longevity. Whether Sirt6 is involved in atherosclerosis, one aging associated disease and the major cause of cardiovascular diseases, is unknown. We investigated effects of Sirt6 on atherosclerosis development. We found that in human atherosclerotic plaques, Sirt6 expression was decreased. Sirt6+/-ApoE-/- mice exhibited increased atherosclerosis development and decreased plaque stability than ApoE-/- mice. We found that Sirt6 downregulation showed increased expression of NKG2D ligands (H60b in mice and MICA/B in human). Sirt6 bound to promoters of these genes and regulated the H3K9 acetylation levels. Thus, atherosclerosis development was promoted by Sirt6 heterozygosity and epigenetic modification of NKG2D ligand expression is involved in this process.

Perinatal Administration of C-Phycocyanin Protects Against Atherosclerosis in apoE-Deficient Mice by Modulating Cholesterol and Trimethylamine-N-Oxide Metabolisms

2021 ◽  
Author(s):  
Marine Coué ◽  
Mikael Croyal ◽  
Marina Habib ◽  
Blandine Castellano ◽  
Audrey Aguesse ◽  
...  
Keyword(s):  
Bile Acid ◽  
Apolipoprotein E ◽  
Lithocholic Acid ◽  
Adult Life ◽  
Density Lipoprotein ◽  
Female Offspring ◽  
Control Group ◽  
Liver Gene ◽  
Atherosclerosis Development ◽  
Deficient Mice

Objective: Gestational hypercholesterolemia concomitantly with a highly oxidative environment is associated with higher atherosclerosis in human and animal offspring. This work aimed to determine whether perinatal administration of a C-phycocyanin concentrate, a powerful antioxidant, can protect against atherosclerosis development in genetically hypercholesterolemic mice in adult life. Approach and Results: C-Phycocyanin was administered during gestation solely or gestation and lactation to apolipoprotein E-deficient mice. Male and female offspring were studied until 25 weeks old. Progenies born to supplemented mothers displayed significantly less atherosclerotic root lesions than control group in all groups excepted in male supplemented during gestation and lactation. Female born to supplemented mothers had a greater gallbladder total bile acid pool, lower secondary hydrophobic bile acid levels such as lithocholic acid, associated with less plasma trimethylamine N -oxide at 16 weeks old compared with control mice. Regarding male born to C-Phycocyanin administrated mothers, they expressed a higher high-density lipoprotein cholesterol level, more soluble bile acids such as β-muricholic acids, and a decreased plasma trimethylamine at 16 weeks old. Liver reduced-to-oxidized glutathione ratio were increased and liver gene expression of superoxide dismutase and glutathione peroxidase were significantly decreased in male born to gestational supplemented mothers. No difference in the composition of cecal microbiota was found between groups, regardless of sex. Conclusions: Our findings suggest a protective effect of perinatal antioxidant administration on atherosclerosis development in apolipoprotein E-deficient mice involving sex-specific mechanisms.

WO12-OR-3 ATHEROSCLEROSIS DEVELOPMENT IN ADULT HETEROZYGOUS APOLIPOPROTEIN E-DEFICIENT MICE OFFSPRING IS DETERMINED IN UTERO BY MATERNAL GENOTYPE

2007 ◽  
Vol 8 (1) ◽  
pp. 12
Author(s):  
F.E. Alkemade ◽  
A.C. Gittenberger-de Groot ◽  
A.E. Schiel ◽  
C.J. van Munsteren ◽  
B. Hogers ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
In Utero ◽  
Maternal Genotype ◽  
Atherosclerosis Development ◽  
Deficient Mice

scholarly journals IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (1) ◽  
pp. e0117255 ◽  
Author(s):  
Polyxeni T. Mantani ◽  
Pontus Dunér ◽  
Eva Bengtsson ◽  
Ragnar Alm ◽  
Irena Ljungcrantz ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Atherosclerosis Development ◽  
Deficient Mice
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