scholarly journals Anti-Inflammatory Effect of Heme Oxygenase-1 Toward Porphyromonas gingivalis Lipopolysaccharide in Macrophages Exposed to Gomisins A, G, and J

2011 ◽  
Vol 14 (12) ◽  
pp. 1519-1526 ◽  
Author(s):  
Eun Yeon Ryu ◽  
Sun Young Park ◽  
Sun Gun Kim ◽  
Da Jung Park ◽  
Jum Soon Kang ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Porphyromonas Gingivalis Lipopolysaccharide ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Anti-Inflammatory Effect of Ecklonia cava Extract on Porphyromonas gingivalis Lipopolysaccharide-Stimulated Macrophages and a Periodontitis Rat Model

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1143 ◽  
Author(s):  
Seonyoung Kim ◽  
Soo-Im Choi ◽  
Gun-Hee Kim ◽  
Jee-Young Imm
Keyword(s):  
Porphyromonas Gingivalis ◽  
Nuclear Factor Κb ◽  
Ecklonia Cava ◽  
Heme Oxygenase 1 ◽  
Therapeutic Effects ◽  
Related Factor ◽  
Nuclear Factor ◽  
Porphyromonas Gingivalis Lipopolysaccharide ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Ecklonia cava, an edible marine brown alga (Laminariaceae), is a rich source of phlorotannins. This study aimed to investigate the anti-inflammatory effect of Ecklonia cava ethanol extract (ECE, dieckol 10.6%, w/w) on Porphyromonas gingivalis lipopolysaccharide-stimulated inflammation in RAW 264.7 cells and in ligature-induced periodontitis in rats. The levels of nitric oxide (NO) and prostaglandin E2 were decreased by more than half on treatment with 100 μg/mL ECE. Downregulated tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 gene expression confirmed the anti-inflammatory properties of ECE. ECE treatment upregulated heme oxygenase-1 (HO-1) expression by 6.3-fold and increased HO-1/nuclear factor erythroid 2-related factor 2 (Nrf-2) signaling decreased nuclear factor-κB (NF-κB) translocation. ECE administration (400 mg/kg) significantly reduced gingival index, restricted tooth mobility, and prevented alveolar bone loss (p < 0.05). These beneficial effects were due to decreased inflammatory cell infiltration, IL-1β production, and matrix metalloproteinase expression in gingival tissues. The ratio of receptor activator of nuclear factor-κB ligand (RANKL)/osteoprotegerin, a biomarker of periodontitis and osteolysis, was significantly decreased by ECE administration (p < 0.05). Thus, ECE has potential therapeutic effects for the alleviation of periodontal disease.

Heme oxygenase-1 mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7 macrophages

2006 ◽  
Vol 106 (3) ◽  
pp. 364-371 ◽  
Author(s):  
Byung-Chul Kim ◽  
Joung-Woo Choi ◽  
Hye-Young Hong ◽  
Sin-Ae Lee ◽  
Suntaek Hong ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Phellinus Linteus ◽  
Raw264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model

2011 ◽  
Vol 411 (2) ◽  
pp. 354-359 ◽  
Author(s):  
Soon Won Kwon ◽  
Eun Jeong Sohn ◽  
Dae Won Kim ◽  
Hoon Jae Jeong ◽  
Mi Jin Kim ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Raw 264.7 Cells ◽  
Heme Oxygenase 1 ◽  
Raw 264.7 ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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