Methanolic Extracts of Plocamium telfairiae Induce Cytotoxicity and Caspase-Dependent Apoptosis in HT-29 Human Colon Carcinoma Cells

2007 ◽  
Vol 10 (4) ◽  
pp. 587-593 ◽  
Author(s):  
Ju-Young Kim ◽  
Mi-Young Yoon ◽  
Mi-Ran Cha ◽  
Ji-Hwan Hwang ◽  
Eunju Park ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Methanolic Extracts ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Ht 29

Antiproliferative Effect of Chitosan-Added Kimchi in HT-29 Human Colon Carcinoma Cells

2010 ◽  
Vol 13 (1) ◽  
pp. 6-12 ◽  
Author(s):  
Chang-Suk Kong ◽  
Young-Eun Bahn ◽  
Boh-Kyung Kim ◽  
Kang-Yoon Lee ◽  
Kun-Young Park
Keyword(s):  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Antiproliferative Effect ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Ht 29

scholarly journals Inhibition of Proprotein Convertases Is Associated with Loss of Growth and Tumorigenicity of HT-29 Human Colon Carcinoma Cells

2001 ◽  
Vol 276 (33) ◽  
pp. 30686-30693 ◽  
Author(s):  
Abdel-Majid Khatib ◽  
Géraldine Siegfried ◽  
Annik Prat ◽  
José Luis ◽  
Michel Chrétien ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Proprotein Convertases ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Ht 29

scholarly journals Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells.

1995 ◽  
Vol 15 (5) ◽  
pp. 2374-2382 ◽  
Author(s):  
J Park ◽  
C A Cartwright
Keyword(s):  
Cell Cycle ◽  
Colon Carcinoma ◽  
Human Colon ◽  
T Antigen ◽  
Carcinoma Cells ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Polyomavirus Middle T Antigen ◽  
Middle T Antigen ◽  
Ht 29

Src and Yes protein-tyrosine kinase activities are elevated in malignant and premalignant tumors of the colon. To determine whether Src activity is elevated throughout the human colon carcinoma cell cycle as it is in polyomavirus middle T antigen- or F527 Src-transformed cells, and whether Yes activity, which is lower than that of Src in the carcinoma cells, is regulated differently, we measured their activities in cycling cells. We observed that the activities of both kinases were higher throughout all phases of the HT-29 colon carcinoma cell cycle than in corresponding phases of the fibroblast cycle. In addition, during mitosis of HT-29 cells, Src specific activity increased two- to threefold more, while Yes activity and abundance decreased threefold. The decreased steady-state protein levels of Yes during mitosis appeared to be due to both decreased synthesis and increased degradation of the protein. Inhibition of tyrosine but not serine/threonine phosphatases abolished the mitotic activation of Src. Mitotic Src was phosphorylated at novel serine and threonine sites and dephosphorylated at Tyr-527. Two cellular proteins (p160 and p180) were phosphorylated on tyrosine only during mitosis. Tyrosine phosphorylation of several other proteins decreased during mitosis. Thus, Src in HT-29 colon carcinoma cells, similar to Src complexed to polyomavirus middle T antigen or activated by mutation at Tyr-527, is highly active in all phases of the cell cycle. Moreover, Src activity further increases during mitosis, whereas Yes activity and abundance decrease. Thus, Src and Yes appear to be regulated differently during mitosis of HT-29 colon carcinoma cells.

scholarly journals Selective Cytotoxic Activity of Valinomycin against HT-29 Human Colon Carcinoma Cells via Down-Regulation of GRP78

2006 ◽  
Vol 29 (4) ◽  
pp. 817-820 ◽  
Author(s):  
In-Ja Ryoo ◽  
Hae-Ryong Park ◽  
Soo-Jin Choo ◽  
Ji-Hwan Hwang ◽  
Young-Min Park ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Ht 29
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