Influence of Genistein Isoflavone on Matrix Metalloproteinase-2 Expression in Prostate Cancer Cells

2006 ◽  
Vol 9 (4) ◽  
pp. 491-497 ◽  
Author(s):  
J.K. Kumi-Diaka ◽  
M. Hassanhi ◽  
K. Merchant ◽  
Vanessa Horman
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Cancer Cells ◽  
Matrix Metalloproteinase 2 ◽  
Prostate Cancer Cells

scholarly journals SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells

The Prostate ◽  
2012 ◽  
Vol 73 (5) ◽  
pp. 522-530 ◽  
Author(s):  
Jenna D. Lovaas ◽  
Lijia Zhu ◽  
Christine Y. Chiao ◽  
Vanessa Byles ◽  
Douglas V. Faller ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Matrix Metalloproteinase ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Matrix Metalloproteinase 2 ◽  
Prostate Cancer Cells

Newly synthesized benzimidazoles inhibits vascular endothelial growth factor and matrix metalloproteinase-2 and -9 levels in prostate cancer cells

2021 ◽  
Vol 21 ◽  
Author(s):  
Suleyman Ilhan ◽  
Gamze Dilekci ◽  
Adem Guner ◽  
Hakan Bektas
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Umbilical Vein ◽  
Imidazole Ring ◽  
Matrix Metalloproteinase 2 ◽  
Benzimidazole Derivatives ◽  
Prostate Cancer Cells ◽  
Protein Levels ◽  
Umbilical Vein Endothelial Cells

Background: Investigating the effects of newly synthesized agents on various molecular mechanisms to understand their mechanism of action is an important step of pre-clinical screening. Benzimidazoles are composed of a unique fused benzene and imidazole ring and have attracted great attention due to their broad bioactivities, including antitumor. Objective: In the current study, we reported the synthesis of novel benzimidazole derivatives and investigated the possible cytotoxic and anti-angiogenic effects on human prostate cancer and umbilical vein endothelial cells (HUVECs). Methods: MTT assay was used to assess cell viability. A scratch assay was conducted to monitor the migration of cells. mRNA expression levels of VEGF, MMP-2, and MMP-9 were evaluated using qPCR. Changes in protein levels were evaluated by western blotting. Results: Compound G1, having a chlorine moiety, showed a potent cytotoxic activity on both prostate cancer cells and HUVECs, and inhibited cell migration via decreasing the mRNA and protein levels of key angiogenesis-related molecules such as VEGF, MMP-2, and MMP-9. Conclusion: These results suggest that newly synthesized G1 may be a novel anti-angiogenic agent for prostate cancer treatment.

Sign in / Sign up

Export Citation Format

Share Document