A Water Extract of Artemisia capillaris Prevents 2,2'-Azobis(2-Amidinopropane) Dihydrochloride-Induced Liver Damage in Rats

2006 ◽  
Vol 9 (3) ◽  
pp. 342-347 ◽  
Author(s):  
Kyu-Ho Han ◽  
You-Jin Jeon ◽  
Yasantha Athukorala ◽  
Kang-Duk Choi ◽  
Cheon-Jei Kim ◽  
...  
Keyword(s):  
Liver Damage ◽  
Water Extract ◽  
Artemisia Capillaris

scholarly journals Antioxidant and hepatoprotective effects of the food seasoning curry leaves Murraya koenigii (L.) Spreng. (Rutaceae)

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100589-100597 ◽  
Author(s):  
Wan Yong Ho ◽  
Boon Kee Beh ◽  
Kian Lam Lim ◽  
Nurul Elyani Mohamad ◽  
Hamidah Mohd Yusof ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gallic Acid ◽  
Liver Damage ◽  
Water Extract ◽  
Leaf Water ◽  
Murraya Koenigii ◽  
Curry Leaves ◽  
Hepatoprotective Effects ◽  
And Oxidative Stress

The curry leaf water extract, which is rich in gallic acid, reversed paracetamol-induced liver damage in mice by reducing inflammation and oxidative stress.

scholarly journals Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Yifeng Zheng ◽  
Agustin Martin-Morales ◽  
Jing Wang ◽  
Masaki Fujishima ◽  
Eri Okumura ◽  
...  
Keyword(s):  
Oral Administration ◽  
Liver Damage ◽  
High Fat Diet ◽  
Mouse Liver ◽  
Water Extract ◽  
Dihydroxyacetone Phosphate ◽  
High Fat ◽  
Hepatic Lipid Accumulation ◽  
Protein Levels ◽  
Gapdh Protein

AbstractThis study examined the effects of oral administration of water extract of chlorella (WEC) (100 mg/kg bodyweight) and phenethylamine (10 μg/kg bodyweight) on high-fat diet (HFD)-induced liver damage in mice. Phenethylamine significantly mitigated HFD-induced lipid oxidation (generation of malondialdehyde) and liver damage without markedly decreasing hepatic lipid accumulation. WEC exerted similar effects although with decreased efficacy. In addition, WEC and phenethylamine decreased the methylglyoxal levels and increased the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels in the liver. Methylglyoxal is generated from substrates of GAPDH, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. These facts indicate that methylglyoxal triggers oxidation of accumulated lipid, which generates malondialdehyde and consequently induces liver damage. Suppression of generation of toxic aldehydes by WEC and phenethylamine was also confirmed by maintaining hepatic cysteine, highly reactive to aldehydes. Thus, trace amounts of phenethylamine alleviate HFD-induced liver damage by regulating methylglyoxal via increase of GAPDH.

scholarly journals Quality of Live Improvement Antituberculosis Consumer

2019 ◽  
Vol 2 (1) ◽  
pp. 22-25
Author(s):  
Jumasni Adnan
Keyword(s):  
Lipid Peroxidation ◽  
Liver Damage ◽  
Water Extract ◽  
Group Iv ◽  
Group V ◽  
Group Iii ◽  
Group I ◽  
Male Wistar Rats ◽  
Group Ii

Antituberculosis is the most liver damage causes. Rifampicin and Isoniazide, in combination, are toxic compounds. Isoniazide and rifampicin metabolits causes lipid peroxidation. The hepatoprotective effect of rosella calyx water extract on liver damage induced with Isoniazide-rifampicin evaluated by examination of malondialdehid levels in the liver organ. 25 male wistar rats divided into 5 groups, ie group I (INH-rifampicin + rosella water extract 250 mg/kgBW), group II (INH-rifampicin + rosella water extract 125 mg/kgBW), group III (INH-rifampicin + rosella water extract 62.5 mg/kgBW),  group IV (healthy control) and group V (Isoniazide-rifampicin). MDA liver levels were analyzed after 35 days of treatments. The test results of each group are, group I has mean MDA levels 0.023912 + 0.011 mg/ml, group II 0.023526 + 0.009 mg/ml, group III 0.027168 + 0.007 mg/ml group IV 0.03437 + 0.009 mg/ml and group V 0.236846 + 0.118 mg/ml. The kruskal-wallis test showed significantly value 0.008 (p 0.05) and Post hoc Mann U whitney test showed that group V was significantly different to group I, II, III, and IV (p = 0.008) respectively, roselle extract can be used as a hepatoprotector antioxidant to improve the tuberculosis drug consumer quality of life through improved health by lowering lipid peroxidation that causes liver damage.

scholarly journals Hepatoprotective Activity of Herbal Composition SAL, a Standardize Blend Comprised ofSchisandra chinensis,Artemisia capillaris, andAloe barbadensis

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Mesfin Yimam ◽  
Ping Jiao ◽  
Breanna Moore ◽  
Mei Hong ◽  
Sabrina Cleveland ◽  
...  
Keyword(s):  
Liver Damage ◽  
Liver Toxicity ◽  
Hepatoprotective Activity ◽  
Functional Tests ◽  
Aloe Barbadensis ◽  
Artemisia Capillaris ◽  
Chemically Induced ◽  
Hepatic Glutathione ◽  
Liver Homogenates ◽  
Potential Use

Some botanicals have been reported to possess antioxidative activities acting as scavengers of free radicals rendering their usage in herbal medicine. Here we describe the potential use of “SAL,” a standardized blend comprised of three extracts fromSchisandra chinensis,Artemisia capillaris, andAloe barbadensis, in mitigating chemically induced acute liver toxicities. Acetaminophen and carbon tetrachloride induced acute liver toxicity models in mice were utilized. Hepatic functional tests from serum collected at T24 and hepatic glutathione and superoxide dismutases from liver homogenates were evaluated. Histopathology analysis and merit of blending 3 standardized extracts were also confirmed. Statistically significant and dose-correlated inhibitions in serum ALT ranging from 52.5% (p=0.004) to 34.6% (p=0.05) in the APAP and 46.3% (p<0.001) to 29.9% (p=0.02) in the CCl4models were observed for SAL administered at doses of 400–250 mg/kg. Moreover, SAL resulted in up to 60.6% and 80.2% reductions in serums AST and bile acid, respectively. The composition replenished depleted hepatic glutathione in association with an increase of hepatic superoxide dismutase. Unexpected synergistic protection from liver damage was also observed. Therefore, the composition SAL could be potentially utilized as an effective hepatic-detoxification agent for the protection from liver damage.

scholarly journals Hepatoprotective Effect of Tagetes Erecta L. Extract on Carbon Tetrachloride Induced Hepatotoxicity in Rats

2019 ◽  
Vol 9 (4-s) ◽  
pp. 269-272
Author(s):  
Kamshetti Manoj Vidyadhar ◽  
Hemant Kumar Sharma
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Damage ◽  
Water Extract ◽  
Free Radical Scavenger ◽  
Hepatoprotective Effect ◽  
Detoxification Enzymes ◽  
Radical Scavenger ◽  
Tagetes Erecta ◽  
Protective Effects ◽  
Tagetes Erecta L

Tagetes erecta L. is a widespread garden plant that is commonly known as the marigold, and it is widely used as a medicinal herb for its anti-inflammatory, analgesic, and anti-edematous properties, which are important for phytotherapeutic, dermatological and cosmetic applications. In this study, the protective effects of water extract of Tagetes erecta L. against liver damage were evaluated in carbon tetrachloride (CCl4)-induced chronic hepatotoxicity in rats. The results showed that the treatment of extract significantly lowered the CCl4-induced serum levels of hepatic enzyme markers (GOT, GPT, ALP, and total bilirubin Liver histopathology showed that extract reduced the incidence of liver lesions including hepatic cells cloudy swelling, lymphocytes infiltration, hepatic necrosis, and fibrous connective tissue proliferation induced by CCl4 in rats. Therefore, the results of this study suggest that Tagetes erecta L. Extract could protect liver against the CCl4-induced oxidative damage in rats, and this hepatoprotective effect might be contributed to its modulation on detoxification enzymes and its antioxidant and free radical scavenger effects. Keywords: Tagetes erecta L., Carbon Tetrachloride, Liver Damage, Hepato-protection

Artemisia capillaris Alleviates Bone Loss by Stimulating Osteoblast Mineralization and Suppressing Osteoclast Differentiation and Bone Resorption

2016 ◽  
Vol 44 (08) ◽  
pp. 1675-1691 ◽  
Author(s):  
Chung-Jo Lee ◽  
Ki-Shuk Shim ◽  
Jin Yeul Ma
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Osteoclast Differentiation ◽  
Water Extract ◽  
Osteoclast Formation ◽  
Bone Diseases ◽  
Osteoporotic Bone ◽  
Nuclear Factor ◽  
Artemisia Capillaris

Artemisia capillaris has been used to treat jaundice and relieve high liver-heat in traditional medicine. In this study, we found that the administration of a water extract from A. capillaris (WEAC) to the receptor activator of nuclear factor kappa-B ligand (RANKL)-induced bone loss model significantly prevents osteoporotic bone loss, increasing bone volume/trabecular volume by 22% and trabecular number by 24%, and decreasing trabecular separation by 29%. WEAC stimulated in vitro osteoblast mineralization from primary osteoblasts in association with increasing expression of osterix, nuclear factor of activated T cells cytoplasmic 1, and activator protein-1, as well as phosphorylation of extracellular signal-regulated kinase. In contrast to the anabolic effect of WEAC, WEAC significantly suppressed in vitro osteoclast formation from bone marrow macrophages by inhibiting the RANKL signaling pathways and bone resorption by downregulating the expression of resorption markers. Therefore, this study demonstrated that WEAC has a beneficial effect on bone loss through the regulation of osteoblast mineralization, as well as osteoclast formation and bone resorption. These results suggest that A. capillaris may be a promising herbal candidate for therapeutic agents to treat or prevent osteoporotic bone diseases.

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