Interleukin-21 Plays an Important Role in CD8 T-Cell Activation and Poor Outcome in HIV Infection

2013 ◽  
Vol 33 (3) ◽  
pp. 115-120 ◽  
Author(s):  
Hua-Ying Zhou ◽  
Yu-Huang Zheng ◽  
Yan He ◽  
Zi Chen ◽  
Mei He ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Poor Outcome ◽  
Interleukin 21

The Dominant Source of CD4+ and CD8+ T-Cell Activation in HIV Infection Is Antigenic Stimulation

2000 ◽  
Vol 25 (3) ◽  
pp. 203-211 ◽  
Author(s):  
James W. T Cohen Stuart ◽  
Mette D Hazebergh ◽  
Dörte Hamann ◽  
Sigrid A Otto ◽  
Jan C. C Borleffs ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Antigenic Stimulation ◽  
Dominant Source

scholarly journals Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion

2019 ◽  
Vol 221 (7) ◽  
pp. 1135-1145 ◽  
Author(s):  
Genevieve E Martin ◽  
Matthew Pace ◽  
Freya M Shearer ◽  
Eva Zilber ◽  
Jacob Hurst ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Hiv Dna ◽  
Art Initiation ◽  
Immunodeficiency Virus

Abstract Initiation of antiretroviral therapy (ART) in early compared with chronic human immunodeficiency virus (HIV) infection is associated with a smaller HIV reservoir. This longitudinal analysis of 60 individuals who began ART during primary HIV infection (PHI) investigates which pre- and posttherapy factors best predict HIV DNA levels (a correlate of reservoir size) after treatment initiation during PHI. The best predictor of HIV DNA at 1 year was pre-ART HIV DNA, which was in turn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-bet−Eomes− subsets), CD8 T-cell activation (CD38 expression) and T-cell immunoglobulin and mucin-domain containing-3 (Tim-3) expression on memory T cells. No associations were found for any immunological variables after 1 year of ART. Levels of HIV DNA are determined around the time of ART initiation in individuals treated during PHI. CD8 T-cell activation and memory expansion are linked to HIV DNA levels, suggesting the importance of the initial host-viral interplay in eventual reservoir size.

scholarly journals Interferon-Alpha Administration Enhances CD8+ T Cell Activation in HIV Infection

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30306 ◽  
Author(s):  
Maura Manion ◽  
Benigno Rodriguez ◽  
Kathleen Medvik ◽  
Gareth Hardy ◽  
Clifford V. Harding ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Interferon Alpha ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell

scholarly journals HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

2019 ◽  
Author(s):  
Genevieve E Martin ◽  
Matthew Pace ◽  
Freya Shearer ◽  
Eva Zilber ◽  
Jacob Hurst ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Effector Memory ◽  
Hiv Reservoir ◽  
Hiv Dna ◽  
Art Initiation ◽  
One Year

AbstractInitiation of antiretroviral therapy (ART) in early compared with chronic HIV infection is associated with a smaller HIV reservoir. This longitudinal analysis of 63 individuals who commenced ART during primary HIV infection (PHI) investigates which pre-and post-therapy factors associate most closely with reservoir size (HIV DNA) following treatment initiation during PHI. The best predictor of reservoir size at one-year was pre-ART HIV DNA which was in turn significantly associated with CD8 memory differentiation (effector memory, naïve and T-betnegEomesnegsubsets), CD8 T cell activation (CD38 expression) and PD-1 and Tim-3 expression on memory CD4 T cells. No associations were found for any immunological variables following one-year of ART. HIV reservoir size is determined around the time of ART initiation in individuals treated during PHI. CD8 T cell activation and memory expansion are linked to HIV reservoir size, suggesting the importance of the initial host-viral interplay in eventual reservoir size.

Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load

Blood ◽  
2004 ◽  
Vol 104 (4) ◽  
pp. 942-947 ◽  
Author(s):  
Steven G. Deeks ◽  
Christina M. R. Kitchen ◽  
Lea Liu ◽  
Hua Guo ◽  
Ron Gascon ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Hiv Disease ◽  
Set Point ◽  
Hiv Rna ◽  
Cell Changes ◽  
Untreated Individuals

AbstractAlthough generalized T-cell activation is an important factor in chronic HIV disease pathogenesis, its role in primary infection remains poorly defined. To investigate the effect of immune activation on T-cell changes in subjects with early HIV infection, and to test the hypothesis that an immunologic activation “set point” is established early in the natural history of HIV disease, a prospective cohort of acutely infected adults was performed. The median density of CD38 molecules on CD4+ and CD8+ T cells was measured longitudinally in 68 antiretroviral-untreated individuals and 83 antiretroviral-treated individuals. At study entry, T-cell activation was positively associated with viremia, with CD8+ T-cell activation levels increasing exponentially at plasma HIV RNA levels more than 10 000 copies/mL. Among untreated patients, the level of CD8+ T-cell activation varied widely among individuals but often remained stable within a given individual. CD8+ T-cell activation and plasma HIV RNA levels over time were independently associated with the rate of CD4+ T-cell loss in untreated individuals. These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time.

scholarly journals Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point

Immunity ◽  
2015 ◽  
Vol 43 (3) ◽  
pp. 591-604 ◽  
Author(s):  
Zaza M. Ndhlovu ◽  
Philomena Kamya ◽  
Nikoshia Mewalal ◽  
Henrik N. Kløverpris ◽  
Thandeka Nkosi ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Set Point ◽  
Kinetics Of

scholarly journals The Dominant Source of CD4+ and CD8+ T-Cell Activation in HIV Infection Is Antigenic Stimulation

2000 ◽  
pp. 203-211 ◽  
Author(s):  
James W. T Cohen Stuart ◽  
Mette D Hazebergh ◽  
D??rte Hamann ◽  
Sigrid A Otto ◽  
Jan C. C Borleffs ◽  
...  
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Antigenic Stimulation ◽  
Dominant Source

T-cell Activation Induces Dynamic Changes in miRNA Expression Patterns in CD4 and CD8 T-cell Subsets

MicroRNA ◽  
2015 ◽  
Vol 4 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Nato Teteloshvili ◽  
Katarzyna Smigielska-Czepiel ◽  
Bart-Jan Kroesen ◽  
Elisabeth Brouwer ◽  
Joost Kluiver ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Mirna Expression ◽  
Cell Activation ◽  
Expression Patterns ◽  
Cd8 T Cell ◽  
T Cell Subsets ◽  
Dynamic Changes
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