Schwannoma Formation in Childhood Cancer Survivors Exposed to Total Body Irradiation: Case Series

2019 ◽  
Vol 8 (4) ◽  
pp. 477-480
Author(s):  
Emily Anderson ◽  
Nadine Linendoll ◽  
Carl B. Heilman ◽  
Ron I. Riesenburger ◽  
Miriam A. O'Leary ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Total Body Irradiation ◽  
Case Series ◽  
Childhood Cancer Survivors ◽  
Total Body

scholarly journals Metreleptin Supplementation for Improving Lipid and Glycemic Profiles in Acquired Diabetes Lipodystrophy: A Case Report

2019 ◽  
Vol 3 (11) ◽  
pp. 2179-2183
Author(s):  
Ayako Nagayama ◽  
Kenji Ashida ◽  
Kanoko Moritaka ◽  
Mami Hidaka ◽  
Mizuki Gobaru ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Stem Cell ◽  
Insulin Sensitivity ◽  
Stem Cell Transplantation ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Total Body Irradiation ◽  
Childhood Cancer Survivors ◽  
Total Body

Abstract Most childhood cancer survivors who undergo hematopoietic stem cell transplantation subsequently develop impaired glucose tolerance and hypertriglyceridemia. These conditions are presumably associated with total-body irradiation–related acquired lipodystrophy and may lead to cardiovascular disease. Metreleptin (recombinant leptin) may help improve the lipoprotein profile, insulin sensitivity, and quality of life of patients with total-body irradiation-related lipodystrophy. This report describes the safe and effective use of metreleptin supplementation for insulin resistance and dyslipidemia in acquired incomplete lipodystrophy. A 24-year-old Japanese woman with diabetes mellitus and hypertriglyceridemia was admitted to our hospital. She was diagnosed with acute lymphocytic leukemia at 3 years of age and had undergone systemic chemotherapy and total-body irradiation before allogeneic stem cell transplantation. She was also diagnosed with hypertriglyceridemia and diabetes mellitus at 11 years of age. She had a low adiponectin level, low-normal leptin level, and diabetes mellitus with marked insulin resistance. Thus, acquired incomplete lipodystrophy was diagnosed. Her serum triglyceride and lipoprotein profiles improved within 1 month of treatment initiation. Glycemic metabolism and insulin sensitivity in the skeletal muscles improved after 6 months. As previously reported, metreleptin therapy is effective in improving lipid and glycemic profiles in generalized lipodystrophy. In the present case, we considered that metreleptin supplementation could reduce the remnant VLDL cholesterol fraction and improve diabetes mellitus. We conclude that it may be an effective alternative therapy for improving the expected prognosis of patients with acquired incomplete lipodystrophy, including childhood cancer survivors.

Secondary bone/soft tissue sarcoma in childhood cancer survivors: a nationwide hospital-based case-series study in Japan

2018 ◽  
Vol 48 (9) ◽  
pp. 806-814 ◽  
Author(s):  
Yasushi Ishida ◽  
Miho Maeda ◽  
Souichi Adachi ◽  
Takeshi Rikiishi ◽  
Maho Sato ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Case Series ◽  
Childhood Cancer Survivors ◽  
Case Series Study ◽  
Series Study

Examining neurodevelopmental outcomes among bilingual childhood cancer survivors

2008 ◽  
Author(s):  
Lauren A. Mikula ◽  
Julie Snyder ◽  
Anai M. Cuadra ◽  
Maria L. Goldman ◽  
Wendy E. Sulc ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Neurodevelopmental Outcomes

Career counselling for childhood cancer survivors: a research study

2016 ◽  
Author(s):  
M. Carmen Fernandez Morante ◽  
Beatriz Cebreiro López ◽  
Josefa del Carmen Fernandez de la Iglesia ◽  
Carol Jean Gillanders ◽  
Isabel Porto Golpe ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Research Study ◽  
Childhood Cancer Survivors ◽  
Career Counselling
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