Feasibility of an Attenuated Maintenance Chemotherapy Regimen Directed at Adolescents and Young Adults with Newly Diagnosed Localized Medulloblastoma and Other Central Nervous System Embryonal Tumors

2014 ◽  
Vol 3 (3) ◽  
pp. 106-111 ◽  
Author(s):  
Jennifer N. Dagri ◽  
Anna Evans ◽  
Joseph C. Torkildson ◽  
Jana Portnow ◽  
Lynn S. Ashby ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Young Adults ◽  
Chemotherapy Regimen ◽  
Adolescents And Young Adults ◽  
Newly Diagnosed ◽  
Maintenance Chemotherapy ◽  
Embryonal Tumors

Liposomal cytarabine for central nervous system embryonal tumors in children and young adults

2010 ◽  
Vol 103 (3) ◽  
pp. 561-566 ◽  
Author(s):  
Sonia Partap ◽  
Patricia A. Murphy ◽  
Hannes Vogel ◽  
Patrick D. Barnes ◽  
Michael S. B. Edwards ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Young Adults ◽  
Liposomal Cytarabine ◽  
Embryonal Tumors ◽  
Children And Young Adults

scholarly journals An epidemiology report for primary central nervous system tumors in adolescents and young adults: a nationwide population-based study in France, 2008–2013

2019 ◽  
Vol 22 (6) ◽  
pp. 851-863 ◽  
Author(s):  
Sam Ng ◽  
Sonia Zouaoui ◽  
Faiza Bessaoud ◽  
Valérie Rigau ◽  
Alexandre Roux ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Young Adults ◽  
Incidence Rates ◽  
Adolescents And Young Adults ◽  
Central Nervous System Tumors ◽  
Crude Rate ◽  
Histological Subtypes ◽  
Nervous System Tumors ◽  
Tumor Identification

Abstract Background Primary central nervous system tumors (PCNST) among adolescents and young adults (AYA, 15–39 y) have rarely been reported. We present a nationwide report of PCNST histologically confirmed in the French AYA population between 2008 and 2013. Methods Patients were identified through the French Brain Tumor Database (FBTDB), a national dataset that includes prospectively all histologically confirmed cases of PCNST in France. Patients aged 15 to 39 years with histologically confirmed PCNST diagnosed between 2008 and 2013 were included. For each of the 143 histological subtypes of PCNST, crude rates, sex, surgery, and age distribution were provided. To enable international comparisons, age-standardized incidence rates were adjusted to the world-standard, European, and USA populations. Results For 6 years, 9661 PCNST (males/females: 4701/4960) were histologically confirmed in the French AYA population. The overall crude rate was 8.15 per 100 000 person-years. Overall, age-standardized incidence rates were (per 100 000 person-years, population of reference: world/Europe/USA): 7.64/8.07/8.21, respectively. Among patients aged 15–24 years, the crude rate was 5.13 per 100 000. Among patients aged 25–39 years, the crude rate was 10.10 per 100 000. Age-standardized incidence rates were reported for each of the 143 histological subtypes. Moreover, for each histological subtype, data were detailed by sex, age, type of surgery (surgical resection or biopsy), and cryopreserved samples. Conclusion These data represent an exhaustive report of all histologically confirmed cases of PCNST with their frequency and distribution in the French AYA population in 2008–2013. For the first time in this age group, complete histological subtypes and rare tumor identification are detailed.

scholarly journals The use of 4-Demethyl-4-cholesteryloxypenclomedine [DM-CHOC-PEN] as Therapy in Adolescent and Young Adult (AYA) Subjects with Advanced Malignancies Involving the Central Nervous System (CNS)

2021 ◽  
pp. 31-33
Author(s):  
Morgan LR ◽  
Weiner RS ◽  
Ware ML ◽  
Bhandari M ◽  
Mahmood T ◽  
...  
Keyword(s):  
United States ◽  
Central Nervous System ◽  
Nervous System ◽  
Young Adults ◽  
Young Adult ◽  
The United States ◽  
Adolescents And Young Adults ◽  
Adolescent And Young Adult ◽  
Advanced Malignancies ◽  
The Central Nervous System

In 2020 about 89,000 adolescents and young adults (AYA) (ages 15 to 39) were estimated to be diagnosed with cancer in the United States, 23,890 had CNS and spinal nervous system(SNS) involvement—accounting for one twentieth or five percent of the number cancer diagnoses in the United States. The estimated deaths for this group was18,020 deaths in 2020 (1).

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