High Prevalence of Chronic Fatigue in Adult Long-Term Survivors of Acute Lymphoblastic Leukemia and Lymphoma During Childhood and Adolescence

2013 ◽  
Vol 2 (1) ◽  
pp. 2-9 ◽  
Author(s):  
Hanne Hamre ◽  
Bernward Zeller ◽  
Adriani Kanellopoulos ◽  
Cecilie E. Kiserud ◽  
Svend Aakhus ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Chronic Fatigue ◽  
Childhood And Adolescence ◽  
High Prevalence ◽  
Long Term Survivors

Anthropometry in Long-Term Survivors of Acute Lymphoblastic Leukemia in Childhood and Adolescence

2017 ◽  
Vol 6 (2) ◽  
pp. 294-298 ◽  
Author(s):  
Laura Collins ◽  
Lesley Beaumont ◽  
Amy Cranston ◽  
Stefanie Savoie ◽  
Trishana Nayiager ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood And Adolescence ◽  
Long Term Survivors

scholarly journals Body composition in long-term survivors of acute lymphoblastic leukemia diagnosed in childhood and adolescence: A focus on sarcopenic obesity

Cancer ◽  
2017 ◽  
Vol 124 (6) ◽  
pp. 1225-1231 ◽  
Author(s):  
Christopher J. C. Marriott ◽  
Lesley F. Beaumont ◽  
Troy H. Farncombe ◽  
Amy N. Cranston ◽  
Uma H. Athale ◽  
...  
Keyword(s):  
Body Composition ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Sarcopenic Obesity ◽  
Childhood And Adolescence ◽  
Long Term Survivors

High Prevalence of Chronic Fatigue in Long Term Survivors of Childhood Acute Lymphoblastic Leukemia and Lymphoma

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 4225-4225
Author(s):  
Hanne Hamre ◽  
Bernward Zeller ◽  
Adriani Kanellopoulos ◽  
Sophie Dorothea Fosså ◽  
Jon Håvar Loge ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
General Population ◽  
Lymphoblastic Leukemia ◽  
Chronic Fatigue ◽  
Diffusion Capacity ◽  
And Gender ◽  
Long Term Survivors ◽  
And Diffusion

Abstract Abstract 4225 Introduction: Chronic fatigue is a frequent and distressing late effect after successful cancer treatment. However, few studies have included survivors of childhood cancers. Aims: The primary aim of the study was to assess the prevalence of fatigue in long-term survivors of childhood acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL), and to compare with the Norwegian general population. A secondary aim was to explore the association between cardiac or pulmonary late effects and fatigue in long-term survivors after NHL and HL. Material and method: This population-based cross-sectional study included tumor-free adult survivors of childhood ALL, NHL and HL diagnosed between 1970 and 2002 at an age of <19 years with at least 5 years follow-up time. The enrolled patients underwent extensive biochemical and clinical investigation including echocardiography and estimation of lung volumes and diffusion capacity. Clinical information was retrieved from the patient records. Chalder′s fatigue questionnaire (FQ) was used to assess fatigue. Chronic fatigue (CF) was defined as a substantially increased level of fatigue with duration of more than 6 months. 1423 age and gender matched individuals from the general Norwegian population served as controls. Results: A total of 290 patients completed the questionnaire (ALL 151, NHL 47, HL 92). Median age (range) at assessment was 29.9 (18.3–54.5) years. Median follow-up time from diagnosis was 21.3 (6.9–39.2) years. The overall prevalence of CF was 27% (ALL 23%, NHL 30%, HL 34%), as compared to 8.4% among the controls (p>0.001). There was a tendency towards a higher prevalence of CF by increasing age (32% among subjects aged ≥30 years at follow-up vs. 22% in subjects aged<30 years, p=0.063). This was most pronounced among the ALL survivors (36% among subjects aged ≥30 years years at follow-up vs. 13% among subjects aged <30 years, p=0.001). In ALL survivors, older age at diagnosis was associated with higher prevalence of CF (15% among subjects aged <6 years at diagnosis vs. 32% among subjects aged ≥6 years, p= 0.012). Indeed, among all survivors ≥6 years at diagnosis, the ALL group had a similar prevalence of CF as the two other diagnostic groups; 32%. No association was found between CF and gender, time from diagnosis, radiotherapy, cumulative anthracycline dose, body mass index, proBNP or hypothyreosis. Among the lymphoma survivors the presence of B-symptoms at diagnosis tended to be associated with CF (Presence: CF 48% vs. Absence: CF 29%, p=0.058). In long-term survivors of NHL and HL, no association was found between CF and aortic valve disease, total lung capacity and diffusion capacity. Conclusions: Compared to the general population the prevalence of CF is 3-fold increased in long-term survivors of childhood leukemia and lymphoma. The prevalence is highest in HL (34%), but, rather surprisingly, even ALL survivors have a high occurrence of CF (23%). The lack of association between CF and somatic co-morbidity or dysfunction warrants future studies exploring the etiology of CF in long-term survivors. Disclosures: No relevant conflicts of interest to declare.

Neurocognitive Outcome in Very Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia After Treatment with Chemotherapy Only

2015 ◽  
Vol 63 (1) ◽  
pp. 133-138 ◽  
Author(s):  
Adriani Kanellopoulos ◽  
Stein Andersson ◽  
Bernward Zeller ◽  
Christian K. Tamnes ◽  
Anders M. Fjell ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Neurocognitive Outcome ◽  
Long Term Survivors
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