Inspiratory Flow Rates through a Novel Dry Powder Inhaler (Clickhaler) in Pediatric Patients with Asthma

1999 ◽  
Vol 12 (2) ◽  
pp. 55-58 ◽  
Author(s):  
NORMAND P. NANTEL ◽  
MICHAEL T. NEWHOUSE
Keyword(s):  
Pediatric Patients ◽  
Dry Powder Inhaler ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Rates

Inspiratory flow rates and volumes with the Aerolizer dry powder inhaler in asthmatic children and adults

2004 ◽  
Vol 20 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Edwin A. Bronsky ◽  
Jay Grossman ◽  
Marc J. Henis ◽  
Paul P. Gallo ◽  
Ümit Yegen ◽  
...  
Keyword(s):  
Dry Powder Inhaler ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Rates ◽  
Asthmatic Children

scholarly journals Clinical effect of Diskus™ dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children

1998 ◽  
Vol 11 (2) ◽  
pp. 350-354 ◽  
Author(s):  
K. G. Nielsen ◽  
I. L. Auk ◽  
K. Bojsen ◽  
M. Ifversen ◽  
B. Klug ◽  
...  
Keyword(s):  
Clinical Effect ◽  
Dry Powder Inhaler ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Rates ◽  
Asthmatic Children

Peak Inspiratory Flow Rates Generated through The Novolizer® And The Turbuhaler® Dry Powder Inhaler Devices by Children with Stable Asthma

2007 ◽  
Vol 20 (1) ◽  
pp. 50-58 ◽  
Author(s):  
Andrea Von Berg ◽  
Hans-Joachim Kremer ◽  
Barbara Ellers-Lenz ◽  
Frank Conrad ◽  
Katharina Erb ◽  
...  
Keyword(s):  
Dry Powder Inhaler ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Rates ◽  
Peak Inspiratory Flow ◽  
Inhaler Devices

Effect of Dry Powder Inhaler Resistance on the Inspiratory Flow Rates and Volumes of Cystic Fibrosis Patients of Six Years and Older

2006 ◽  
Vol 19 (4) ◽  
pp. 456-465 ◽  
Author(s):  
H.A. Tiddens ◽  
D.E. Geller ◽  
P. Challoner ◽  
R.J. Speirs ◽  
K.C. Kesser ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Dry Powder Inhaler ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Rates

A generic fluticasone propionate and salmeterol dry powder inhaler: Evidence of usability, function, and robustness

2021 ◽  
Vol 42 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Donald P. Tashkin ◽  
Arkady Koltun ◽  
Róisín Wallace
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Fluticasone Propionate ◽  
Healthy Volunteers ◽  
Pulmonary Disease ◽  
Dry Powder Inhaler ◽  
Chemical Degradation ◽  
Chronic Obstructive ◽  
Dry Powder ◽  
Obstructive Pulmonary Disease ◽  
Flow Rates

Background: A generic combination of fluticasone propionate and salmeterol xinafoate inhalation powder in a premetered, multidose, nonreusable inhaler was recently approved. Objective: To assess the performance of the generic device. Methods: Findings from three studies with regard to device usability, function, and robustness were reviewed. Results: In a study to assess device function in patients and healthy volunteers, the generic device was successfully used by patients with asthma and chronic obstructive pulmonary disease who were either dry powder inhaler users or dry powder inhaler‐naive, even though they were not trained beyond being provided the instructions for use. In a study to measure inhaled flow rates generated by patients and healthy volunteers, the generic device consistently simulated the delivery of a full dose of drug, even to patients with severe respiratory disease and reduced inspiratory flow rates. Although the generic device had a slightly higher airflow resistance, this study demonstrated that this difference did not result in any clinically meaningful differences in terms of drug delivery. Pressure drop, a key parameter that drives the fluidization and aerosolization of the powder dose, was found to be comparable between the devices. In an open-label study, the generic device met all U.S. Food and Drug Administration specifications for device robustness after 21.5 days of twice-daily dosing via oral inhalation among 111 participants with asthma or chronic obstructive pulmonary disease. All inhalers tested demonstrated conformity with a pharmacopeia with respect to key quality parameters (assay, delivered dose uniformity, aerodynamic size distribution). There was no evidence of chemical degradation of the active ingredients, nor of microbial or water ingress into the powder, as a result of inhaler use.

Clickhaler (a Novel Dry Powder Inhaler) Provides Similar Bronchodilation to Pressurized Metered-Dose Inhaler, Even at Low Flow Rates

CHEST Journal ◽  
1999 ◽  
Vol 115 (4) ◽  
pp. 952-956 ◽  
Author(s):  
Michael T. Newhouse ◽  
Normand P. Nantel ◽  
Carole B. Chambers ◽  
Barbara Pratt ◽  
Mark Parry-Billings
Keyword(s):  
Dry Powder Inhaler ◽  
Low Flow ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Dry Powder ◽  
Flow Rates ◽  
Metered Dose ◽  
Pressurized Metered Dose Inhaler

scholarly journals Development of an adaptive bypass element for passive entrainment flow control in dry powder inhalers

2019 ◽  
Vol 233 (15) ◽  
pp. 5201-5213
Author(s):  
Thomas Kopsch ◽  
Darragh Murnane ◽  
Digby Symons
Keyword(s):  
Drug Delivery ◽  
Dry Powder Inhaler ◽  
Experimental Methods ◽  
Dry Powder Inhalers ◽  
Total Flow ◽  
Dry Powder ◽  
Flow Rates ◽  
Inhaler Device ◽  
Flow Resistances ◽  
Flap Valve

The release of drug from dry powder inhalers is strongly dependent on the patient's inhalation profile. To maximise the effect of the treatment, it is necessary to optimise dry powder inhalers to achieve drug delivery that (A) is independent of the inhalation manoeuvre and (B) is targeted to the correct site in the lung. The purpose of this study is to develop a dry powder inhaler with an adaptive bypass element that achieves desired drug delivery behaviour. Computational and experimental methods are used. First, the effect of a generic variable bypass element on entrainment behaviour is modelled. This is done by modelling a dry powder inhaler as a network of flow. Second, the behaviour of a potential variable bypass element, a flap valve, is studied both computationally and experimentally. Third, the flow resistances are optimised to achieve consistent and desired entrainment behaviour for patients with very different inhalation manoeuvres. A simulated dry powder inhaler device design was found that achieves an approximately constant entrainment flow rate of 12 L/min when total flow rates larger than 20 L/min are applied. The developed dry powder inhaler is predicted to accurately deliver drug for patients with highly different inhalation manoeuvres.

scholarly journals Assessment of inhalation flow patterns of soft mist inhaler co-prescribed with dry powder inhaler using inspiratory flow meter for multi inhalation devices

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0193082 ◽  
Author(s):  
Daiki Hira ◽  
Hiroyoshi Koide ◽  
Shigemi Nakamura ◽  
Toyoko Okada ◽  
Kazunori Ishizeki ◽  
...  
Keyword(s):  
Dry Powder Inhaler ◽  
Flow Patterns ◽  
Inspiratory Flow ◽  
Dry Powder ◽  
Flow Meter ◽  
Inhalation Devices
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