Size Analysis of a Pressurized Metered Dose Inhaler–Delivered Suspension Formulation by the API Aerosizer Time-of-Flight Aerodynamic Particle Size Analyzer

1999 ◽  
Vol 12 (4) ◽  
pp. 255-264 ◽  
Author(s):  
JOLYON P. MITCHELL ◽  
MARK W. NAGEL ◽  
ALLAN D. ARCHER
Keyword(s):  
Particle Size ◽  
Time Of Flight ◽  
Dose Inhaler ◽  
Size Analysis ◽  
Metered Dose Inhaler ◽  
Suspension Formulation ◽  
Particle Size Analyzer ◽  
Metered Dose ◽  
Aerodynamic Particle Size ◽  
Pressurized Metered Dose Inhaler

Dosing Efficiency and Particle-size Characteristics of Pressurized Metered-dose Inhaler Aerosols in Narrow Catheters

CHEST Journal ◽  
1993 ◽  
Vol 103 (3) ◽  
pp. 920-924 ◽  
Author(s):  
Robert H. Taylor ◽  
Jerrold Lerman ◽  
Carole Chambers ◽  
Myrna Dolovich
Keyword(s):  
Particle Size ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Metered Dose ◽  
Pressurized Metered Dose Inhaler

EVALUATION OF AERODYNAMIC PARTICLE SIZE DISTRIBUTION OF DRUGS USED IN INHALATION THERAPY: A CONCISE REVIEW

2020 ◽  
Vol 8 (7) ◽  
pp. 264-271
Author(s):  
Smita Nayak ◽  
Priyanka Ghugare ◽  
Bhaskar Vaidhun
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Dry Powder Inhaler ◽  
Dose Inhaler ◽  
Metered Dose Inhaler ◽  
Aerodynamic Particle Size Distribution ◽  
Metered Dose ◽  
Aerodynamic Particle Size ◽  
Cascade Impactors

Most of the inhalation products in the market use metered dose inhaler (MDI) technology or dry powder inhaler (DPI) technology. MDIs use propellant to deliver desired dose of liquid formulation in aerosol form. DPI contains active in fine particulate form embedded onto an inert carrier. In both cases, amount of drug dispensed from the device reaching the lungs is dependent upon drug product characteristics as well as formulation-device relationship. Hence, in addition to particle size, aerodynamic distribution of the drug upon delivery by the device plays an important role in determining amount of drug reaching the lungs. Therefore particle size characterization is an important tool in determining the extent of drug delivery from the metered dose inhaler. Aerodynamic particle size distribution is frequently determined by use of cascade impactors and data so generated is accepted by regulatory agencies as a tool for predicting efficacy of MDIs and DPIs. This review discusses principle and working of cascade impactors. Additionally, the review also examines the role of laser diffraction technique in estimating size of dispersed particles.

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