Improved Potency And Safety Of DNA-encoded Antibody Therapeutics Through Plasmid Backbone And Expression Cassette Engineering

2021 ◽  
Author(s):  
Giles Vermeire ◽  
Elien De Smidt ◽  
Nick Geukens ◽  
James A Williams ◽  
Paul Declerck ◽  
...  
Keyword(s):  
Expression Cassette ◽  
Antibody Therapeutics ◽  
Plasmid Backbone

scholarly journals Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels

2020 ◽  
Vol 3 (4) ◽  
pp. 257-264
Author(s):  
Catherine J Hutchings
Keyword(s):  
Ion Channels ◽  
Research And Development ◽  
Small Molecules ◽  
G Protein ◽  
Clinical Studies ◽  
G Protein Coupled Receptors ◽  
Protein Targets ◽  
Antibody Therapeutics ◽  
Wide Range ◽  
G Protein Coupled

Abstract Antibodies are now well established as therapeutics with many additional advantages over small molecules and peptides relative to their selectivity, bioavailability, half-life and effector function. Major classes of membrane-associated protein targets include G protein-coupled receptors (GPCRs) and ion channels that are linked to a wide range of disease indications across all therapeutic areas. This mini-review summarizes the antibody target landscape for both GPCRs and ion channels as well as current progress in the respective research and development pipelines with some example case studies highlighted from clinical studies, including those being evaluated for the treatment of symptoms in COVID-19 infection.

Simple strategy for bone regeneration with a BMP-2/7 gene expression cassette vector

2009 ◽  
Vol 390 (3) ◽  
pp. 1012-1017 ◽  
Author(s):  
Mariko Kawai ◽  
Hiroki Maruyama ◽  
Kazuhisa Bessho ◽  
Hiromitsu Yamamoto ◽  
Jun-Ichi Miyazaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Regeneration ◽  
Expression Cassette ◽  
Simple Strategy ◽  
Gene Expression Cassette ◽  
Cassette Vector

scholarly journals Bioassay Development for Bispecific Antibodies—Challenges and Opportunities

2021 ◽  
Vol 22 (10) ◽  
pp. 5350
Author(s):  
Ames C. Register ◽  
Somayeh S. Tarighat ◽  
Ho Young Lee
Keyword(s):  
Mechanism Of Action ◽  
Bispecific Antibodies ◽  
Structural Variations ◽  
Antibody Therapeutics ◽  
Regulatory Guidelines ◽  
Different Types ◽  
Challenges And Opportunities ◽  
Target Binding ◽  
Monospecific Antibodies ◽  
Complicated Mechanism

Antibody therapeutics are expanding with promising clinical outcomes, and diverse formats of antibodies are further developed and available for patients of the most challenging disease areas. Bispecific antibodies (BsAbs) have several significant advantages over monospecific antibodies by engaging two antigen targets. Due to the complicated mechanism of action, diverse structural variations, and dual-target binding, developing bioassays and other types of assays to characterize BsAbs is challenging. Developing bioassays for BsAbs requires a good understanding of the mechanism of action of the molecule, principles and applications of different bioanalytical methods, and phase-appropriate considerations per regulatory guidelines. Here, we review recent advances and case studies to provide strategies and insights for bioassay development for different types of bispecific molecules.

scholarly journals Adenoviral Type 35 and 26 Vectors with a Bidirectional Expression Cassette in the E1 Region Show an Improved Genetic Stability Profile and Potent Transgene-Specific Immune Response

2018 ◽  
Vol 29 (3) ◽  
pp. 337-351
Author(s):  
Marija Vujadinovic ◽  
Kerstin Wunderlich ◽  
Benoit Callendret ◽  
Marina Koning ◽  
Mark Vermeulen ◽  
...  
Keyword(s):  
Immune Response ◽  
Genetic Stability ◽  
Expression Cassette ◽  
Specific Immune Response
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