Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

Michael J. Castle; Fernando C. Baltanás; Imre Kovacs; Alan H. Nagahara; David Barba; Mark H. Tuszynski

doi:10.1089/hum.2019.367

Postmortem Analysis in a Clinical Trial of AAV2-NGF Gene Therapy for Alzheimer's Disease Identifies a Need for Improved Vector Delivery

Human Gene Therapy ◽

10.1089/hum.2019.367 ◽

2020 ◽

Vol 31 (7-8) ◽

pp. 415-422 ◽

Cited By ~ 3

Author(s):

Michael J. Castle ◽

Fernando C. Baltanás ◽

Imre Kovacs ◽

Alan H. Nagahara ◽

David Barba ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Vector Delivery ◽

Ngf Gene

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P2-027: TARGET ENGAGEMENT IN A PHASE II CLINICAL TRIAL OF AAV2-NGF GENE THERAPY FOR ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.711 ◽

2006 ◽

Vol 14 (7S_Part_12) ◽

pp. P677-P677

Author(s):

Michael J. Castle ◽

Fernando Calvo Baltanas ◽

Imre Kovacs ◽

Alan H. Nagahara ◽

Krystof S. Bankiewicz ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Phase Ii ◽

Phase Ii Clinical Trial ◽

Target Engagement ◽

Ngf Gene

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Analyses of a Phase 1 Clinical Trial of Adeno- associated Virus-Nerve Growth Factor (CERE-110) Gene Therapy in Alzheimer's Disease

Neurosurgery ◽

10.1227/01.neu.0000279944.12903.2c ◽

2007 ◽

Vol 61 (1) ◽

pp. 216-216 ◽

Cited By ~ 4

Author(s):

Roy A.E. Bakay ◽

Zoe Arvanitakis ◽

Mark Tuszynski ◽

Steve Potkin ◽

Ray Bartus ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy ◽

Nerve Growth Factor ◽

Growth Factor ◽

Phase 1 ◽

Adeno Associated Virus ◽

Nerve Growth ◽

Phase 1 Clinical Trial

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NGF gene therapy for Alzheimer's disease

Experimental Neurology ◽

10.1016/j.expneurol.2006.02.024 ◽

2006 ◽

Vol 198 (2) ◽

pp. 561

Author(s):

A. Blesch ◽

Mark H. Tuszynski

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gene Therapy ◽

Ngf Gene

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Daily briefing: Clinical trial will target Alzheimer’s disease with gene therapy

Nature ◽

10.1038/d41586-019-00712-x ◽

2019 ◽

Author(s):

Flora Graham

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Gene Therapy

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IMPROVED INTRATHECAL VECTOR DELIVERY FOR GENE THERAPY IN ALZHEIMER’S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2019.06.4868 ◽

2019 ◽

Vol 15 (7) ◽

pp. P1630

Author(s):

Michael J. Castle ◽

Yuhsiang Cheng ◽

Aravind Asokan ◽

Mark H. Tuszynski

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gene Therapy ◽

Vector Delivery

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A Randomized, Double-Blind Phase 2b Proof of Concept Clinical Trial in Early Alzheimer's Disease with BAN2401, an Anti-Aβ Protofibril Antibody

SSRN Electronic Journal ◽

10.2139/ssrn.3672342 ◽

2020 ◽

Author(s):

Chad Swanson ◽

Yong Zhang ◽

Shobha Dhadda ◽

Jinping Wang ◽

June Kaplow ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Proof Of Concept ◽

Double Blind ◽

Early Alzheimer’S Disease

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Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of Alzheimer’s disease

Molecular Therapy — Methods & Clinical Development ◽

10.1016/j.omtm.2021.03.021 ◽

2021 ◽

Author(s):

Shanshan Wang ◽

Joseph S. Leem ◽

Sonia Podvin ◽

Vivian Hook ◽

Natalia Kleschevnikov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gene Therapy ◽

Mouse Model ◽

Caveolin 1 ◽

Model Of Alzheimer’S Disease

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Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer’s disease

Brain Research ◽

10.1016/j.brainres.2020.147264 ◽

2021 ◽

pp. 147264

Author(s):

Lauren V. Owens ◽

Alexandre Benedetto ◽

Neil Dawson ◽

Christopher J. Gaffney ◽

Edward T. Parkin

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Gene Therapy ◽

Protein Expression

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Medical nutrition in Alzheimer's disease: First results and clinical trial

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.09.213 ◽

2011 ◽

Vol 668 ◽

pp. e8-e9 ◽

Cited By ~ 1

Author(s):

P. Scheltens

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

First Results ◽

Medical Nutrition

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P4-045: Longitudinal ADC changes in Alzheimer's disease in a multi-center clinical trial setting

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.2065 ◽

2011 ◽

Vol 7 ◽

pp. S713-S713

Author(s):

Luc Bracoud ◽

Angelika Caputo ◽

Chahin Pachai ◽

Boubakeur Belaroussi ◽

Ana Graf ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Clinical Trial ◽

Clinical Trial Setting ◽

Trial Setting

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