Effects of inhibition of miR-155-5p in neural stem cell subarachnoid transplant on rats with cerebral infarction

2019 ◽  
Author(s):  
Dong Wang ◽  
Liang Wang ◽  
Lin Bai ◽  
Yuanyuan Du ◽  
Luji Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cerebral Infarction ◽  
Neural Stem Cell

Effects of Inhibition of miR-155-5p in Neural Stem Cell Subarachnoid Transplant on Rats with Cerebral Infarction

2019 ◽  
Vol 30 (5) ◽  
pp. 184-193
Author(s):  
Dong Wang ◽  
Liang Wang ◽  
Lin Bai ◽  
Yuanyuan Du ◽  
Luji Liu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cerebral Infarction ◽  
Neural Stem Cell

scholarly journals The Long-Term Outcome Comparison of Different Time-Delayed Kallikrein Treatments in a Mouse Cerebral Ischemic Model

2018 ◽  
Vol 2018 ◽  
pp. 1-11
Author(s):  
Yaohui Ni ◽  
Kefu Cai ◽  
Yujie Hu ◽  
Chuan-hui Wang ◽  
Yuanyuan Zhang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cerebral Infarction ◽  
Signaling Pathway ◽  
Neural Stem Cell ◽  
Neurological Dysfunction ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Vegf Signaling ◽  
Vegf Signaling Pathway

Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time points following mouse cerebral ischemia. Furthermore, the protective mechanisms involving neurogenesis, angiogenesis, and AKT-GSK3β-VEGF signaling pathway were analyzed. Human tissue kallikrein was injected through the tail vein daily starting at 8 h, 24 h, or 36 h after right middle cerebral artery occlusion (MCAO) until the 28th day. Three therapeutic regimens all protected against neurological dysfunction, but kallikrein treatment starting at 8 h after MCAO had the best efficacy. Additionally, kallikrein treatment at 8 h after MCAO significantly enhanced cell proliferation including neural stem cell and induced differentiation of neural stem cell into mature neuron. Kallikrein treatment starting at 8 h also promoted more angiogenesis than other two treatment regimens, which was associated with AKT-GSK3β-VEGF signaling pathway. Thus, we confirm that three delayed kallikrein treatments provide protection against cerebral infarction and furthermore suggest that kallikrein treatment starting at 8 h had a better effect than that at 24 h and 36 h. These findings provide the experimental data contributing to better clinical application of exogenous kallikrein.

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors

Neural Stem Cell Culture: Neurosphere generation, microscopical analysis and cryopreservation

2006 ◽  
Author(s):  
Laura Pacey ◽  
Shelley Stead ◽  
Jacqueline Gleave ◽  
Kasia Tomczyk ◽  
Laurie Doering
Keyword(s):  
Cell Culture ◽  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Culture ◽  
Microscopical Analysis
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