Insights into Gene Therapy for Urea Cycle Defects by Mathematical Modeling

2019 ◽  
Vol 30 (11) ◽  
pp. 1385-1394 ◽  
Author(s):  
Cindy Y. Kok ◽  
Sharon C. Cunningham ◽  
Philip W. Kuchel ◽  
Ian E. Alexander
Keyword(s):  
Mathematical Modeling ◽  
Gene Therapy ◽  
Urea Cycle ◽  
Urea Cycle Defects

Plasma carnosinase deficiency in patients with urea cycle defects

1975 ◽  
Vol 61 (2) ◽  
pp. 215-218 ◽  
Author(s):  
E.Ann Burgess ◽  
V.G. Oberholzer ◽  
T. Palmer ◽  
B. Levin
Keyword(s):  
Urea Cycle ◽  
Urea Cycle Defects

Tuning optimum transfection of gemini surfactant–phospholipid–DNA nanoparticles by validated theoretical modeling

Nanoscale ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 1037-1046 ◽  
Author(s):  
Sattar Taheri-Araghi ◽  
Ding-Wen Chen ◽  
Mohammad Kohandel ◽  
Sivabal Sivaloganathan ◽  
Marianna Foldvari
Keyword(s):  
Mathematical Modeling ◽  
Gene Therapy ◽  
Gemini Surfactant ◽  
Transfection Efficiency ◽  
Structural Features ◽  
Coarse Grained ◽  
Viral Gene ◽  
Dna Nanoparticles ◽  
Non Invasive ◽  
Viral Gene Delivery

Coarse-grained mathematical modeling using the polymorphic structural features of gemini nanoparticles assists designing non-viral gene delivery systems with high transfection efficiency for applications in non-invasive gene therapy.

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