Overexpression of Hepatocyte Growth Factor mRNA Induced by Gene Transfer Attenuates Neointimal Hyperplasia After Balloon Injury

2018 ◽  
Vol 29 (7) ◽  
pp. 816-827
Author(s):  
Yu He ◽  
Li Mei ◽  
Ying Jin ◽  
Xiao-Ping Li ◽  
Chunxiang Jin
Keyword(s):  
Growth Factor ◽  
Gene Transfer ◽  
Hepatocyte Growth Factor ◽  
Neointimal Hyperplasia ◽  
Balloon Injury ◽  
Hepatocyte Growth Factor Mrna ◽  
Hepatocyte Growth

scholarly journals 1868: Prevention of Chronic Allograft Nephropathy(CAN) With Hepatocyte Growth Factor (HGF) Gene Transfer

2004 ◽  
Vol 171 (4S) ◽  
pp. 493-493
Author(s):  
Ryoichi Imamura ◽  
Shiro Takahara ◽  
Yukiomi Namba ◽  
Yi Shi ◽  
Koji Yazawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Transfer ◽  
Hepatocyte Growth Factor ◽  
Chronic Allograft Nephropathy ◽  
Hepatocyte Growth

Enhancement of retrovirus-mediated gene transfer to rat liver in vivo by infusion of hepatocyte growth factor and triiodothyronine

2000 ◽  
Vol 33 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Hisaka Minami ◽  
Kouji Tada ◽  
Namita Roy Chowdhury ◽  
Jayanta Roy Chowdhury ◽  
Morikazu Onji
Keyword(s):  
Growth Factor ◽  
Gene Transfer ◽  
Hepatocyte Growth Factor ◽  
Rat Liver ◽  
Hepatocyte Growth

scholarly journals The effect of gene transfer with hepatocyte growth factor for pulmonary vascular hypoplasia in neonatal porcine model

2005 ◽  
Vol 129 (4) ◽  
pp. 740-745 ◽  
Author(s):  
Masamichi Ono ◽  
Yoshiki Sawa ◽  
Yuji Miyamoto ◽  
Norihide Fukushima ◽  
Hajime Ichikawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Gene Transfer ◽  
Hepatocyte Growth Factor ◽  
Porcine Model ◽  
Hepatocyte Growth

Neonatal or hepatocyte growth factor–potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B

Blood ◽  
2003 ◽  
Vol 101 (10) ◽  
pp. 3924-3932 ◽  
Author(s):  
Lingfei Xu ◽  
Cuihua Gao ◽  
Mark S. Sands ◽  
Shi-Rong Cai ◽  
Timothy C. Nichols ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Growth Factor ◽  
Gene Transfer ◽  
Hepatocyte Growth Factor ◽  
Retroviral Vector ◽  
Factor Ix ◽  
Hemophilia B ◽  
Hepatocyte Growth

AbstractHemophilia B is a bleeding disorder resulting from factor IX (FIX) deficiency that might be treated with gene therapy. Neonatal delivery would correct the disease sooner than would transfer into adults, and could reduce immunological responses. Neonatal mice were injected intravenously with a Moloney murine leukemia virus–based retroviral vector (RV) expressing canine FIX (cFIX). They achieved 150% to 280% of normal cFIX antigen levels in plasma (100% is 5 μg/mL), which was functional in vitro and in vivo. Three newborn hemophilia B dogs that were injected intravenously with RV achieved 12% to 36% of normal cFIX antigen levels, which improved coagulation tests. Only one mild bleed has occurred during 14 total months of evaluation. This is the first demonstration of prolonged expression after neonatal gene therapy for hemophilia B in mice or dogs. Most animals failed to make antibodies to cFIX, demonstrating that neonatal gene transfer may induce tolerance. Although hepatocytes from newborns replicate, those from adults do not. Adult mice therefore received hepatocyte growth factor to induce hepatocyte replication prior to intravenous injection of RV. This resulted in expression of 35% of normal cFIX antigen levels for 11 months, although all mice produced anti-cFIX antibodies. This is the first demonstration that high levels of FIX activity can be achieved with an RV in adults without a partial hepatectomy to induce hepatocyte replication. We conclude that RV-mediated hepatic gene therapy is effective for treating hemophilia B in mice and dogs, although the immune system may complicate gene transfer in adults.

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