An Oncolytic Adenovirus Expressing SNORD44 and GAS5 Exhibits Antitumor Effect in Colorectal Cancer Cells

2017 ◽  
Vol 28 (8) ◽  
pp. 690-700 ◽  
Author(s):  
Sujing Yuan ◽  
Yu Wu ◽  
Yigang Wang ◽  
Jianhua Chen ◽  
Liang Chu
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Oncolytic Adenovirus ◽  
Colorectal Cancer Cells

scholarly journals Combination of oncolytic adenovirus and luteolin exerts synergistic antitumor effects in colorectal cancer cells and a mouse model

2017 ◽  
Vol 16 (6) ◽  
pp. 9375-9382 ◽  
Author(s):  
Boduan Xiao ◽  
Yun Qin ◽  
Chang Ying ◽  
Buyun Ma ◽  
Binrong Wang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Mouse Model ◽  
Cancer Cells ◽  
Oncolytic Adenovirus ◽  
Antitumor Effects ◽  
Colorectal Cancer Cells

scholarly journals Synergistic antitumor effect of brusatol combined with cisplatin on colorectal cancer cells

2018 ◽  
Author(s):  
Hai‑Ming Chen ◽  
Zheng‑Quan Lai ◽  
Hui‑Jun Liao ◽  
Jian‑Hui Xie ◽  
Yan‑Fang Xian ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect ◽  
Colorectal Cancer Cells

scholarly journals Synergistic Suppression Effect on Tumor Growth of Colorectal Cancer by Combining Radiotherapy With a TRAIL-Armed Oncolytic Adenovirus

2019 ◽  
Vol 18 ◽  
pp. 153303381985329 ◽  
Author(s):  
Hangxiang Gao ◽  
Xin Zhang ◽  
Ying Ding ◽  
Rong Qiu ◽  
Yupeng Hong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Necrosis Factor ◽  
Antitumor Activity ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Xenograft Model ◽  
Oncolytic Adenovirus ◽  
Apoptotic Pathway ◽  
Colorectal Cancer Cells ◽  
Necrosis Factor

The combination of gene therapy and radiation is a promising new treatment for cancer. This study aimed to clarify the synergistic effect of targeted oncolytic adenovirus (radiotherapy-tumor necrosis factor-related apoptosis-inducing ligand) and radiotherapy on colorectal cancer cells and elucidate the mechanisms of the underlying antitumor activity. Viability, cell cycle status, and apoptosis of treated colorectal cancer cells were determined via MTT and flow cytometric assays. The molecular mechanism underlying apoptotic pathway activation was elucidated through Western blot analysis of caspase-8, caspase-3, and PARP proteins. Combination treatment with radiotherapy-tumor necrosis factor-related apoptosis-inducing ligand and radiotherapy displayed significantly greater antitumor activity than either of the monotherapies. The primary mechanism behind the antitumor activity in the SW480 and Lovo colorectal cancer cell lines was apoptosis induction through the caspase pathway and G1 phase arrest. In an SW480 xenograft model of colorectal cancer, the combination therapy achieved a significantly greater reduction in tumor volume than the monotherapies. Overall, in this study, we demonstrate that the oncolytic radiotherapy-tumor necrosis factor-related apoptosis-inducing ligand construct can sensitize human colorectal cancer cells to radiation-induced apoptosis both in vitro and in vivo. Therefore, our findings point toward a novel synergistic approach to colorectal cancer treatment.

scholarly journals Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells

2015 ◽  
Vol 17 (8) ◽  
pp. 849-858 ◽  
Author(s):  
Donatella Fiore ◽  
Maria Chiara Proto ◽  
Simona Pisanti ◽  
Paola Picardi ◽  
Antonio Christian Pagano Zottola ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Synergistic Effect ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Colorectal Cancer Cells

Temsirolimus and chloroquine cooperatively exhibit a potent antitumor effect against colorectal cancer cells

2014 ◽  
Vol 140 (5) ◽  
pp. 769-781 ◽  
Author(s):  
Manabu Kaneko ◽  
Hiroaki Nozawa ◽  
Masaya Hiyoshi ◽  
Noriko Tada ◽  
Koji Murono ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Antitumor Effect ◽  
Colorectal Cancer Cells
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