Delivery of an Adeno-Associated Virus Vector into Cerebrospinal Fluid Attenuates Central Nervous System Disease in Mucopolysaccharidosis Type II Mice

2016 ◽  
Vol 27 (11) ◽  
pp. 906-915 ◽  
Author(s):  
Christian Hinderer ◽  
Nathan Katz ◽  
Jean-Pierre Louboutin ◽  
Peter Bell ◽  
Hongwei Yu ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Virus Vector ◽  
Mucopolysaccharidosis Type ◽  
Type Ii ◽  
Mucopolysaccharidosis Type Ii ◽  
Adeno Associated Virus ◽  
System Disease

scholarly journals Testing forBartonellassp. DNA in cerebrospinal fluid of dogs with inflammatory central nervous system disease

2018 ◽  
Vol 32 (6) ◽  
pp. 1983-1988 ◽  
Author(s):  
Lisa R. Bartner ◽  
Stephanie McGrath ◽  
Adam Drury ◽  
Annie V. Chen ◽  
Arianne Morris ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease

scholarly journals Inflammatory cerebrospinal fluid analysis in cats: Clinical diagnosis and outcome

2005 ◽  
Vol 7 (2) ◽  
pp. 77-93 ◽  
Author(s):  
M. Singh ◽  
D.J. Foster ◽  
G. Child ◽  
W.A. Lamb
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Cell Count ◽  
Clinical Signs ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Differential Count ◽  
System Disease ◽  
Csf Analysis

The medical records of 62 cats with clinical signs of central nervous system disease and accompanying inflammatory cerebrospinal fluid (CSF) analysis were examined retrospectively to determine if signalment, clinical signs, CSF analysis and ancillary testing could accurately predict the type of central nervous system disease that was present. An inflammatory CSF was defined as one in which a total nucleated cell count was greater than 5 cells/μl or one in which the total nucleated cell count was normal but the nucleated cell differential count was abnormal. Sex, degree of CSF inflammation, neuroanatomical location and systemic signs provided little contributory information to the final diagnosis. In 63% of the cases a presumptive diagnosis could be made based on a combination of clinical signs, clinicopathological data and ancillary diagnostic tests. CSF analysis alone was useful only in the diagnosis of cats with feline infectious peritonitis, Cryptococcus species infection, lymphoma and trauma. Overall, despite extensive diagnostic evaluation, a specific diagnosis could not be made in 37% of cats. The prognosis for cats with inflammatory CSF was poor with 77% of cats surviving less than 1 year.

CEREBROSPINAL FLUID LDH IN 287 CHILDREN, INCLUDING 53 CASES OF MENINGITIS OF BACTERIAL AND NON-BACTERIAL ETIOLOGY

PEDIATRICS ◽  
1968 ◽  
Vol 41 (6) ◽  
pp. 1097-1103
Author(s):  
William Neches ◽  
Martin Platt
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Dehydrogenase Activity ◽  
Newborn Infants ◽  
Central Nervous System Disease ◽  
Lactic Dehydrogenase ◽  
Spinal Fluid ◽  
Initial Examination ◽  
System Disease

Cerebrospinal fluid lactic dehydrogenase activity was determined in 287 children. Among these, 87 had no central nervous system disease and were considered to be controls. Mean lactic dehydrogenase activity in 69 controls (excluding newborn infants) was 14 units. In 18 control infants less than 1 week of age, the mean lactic dehydrogenase activity was 50 units. Thirty-two patients with bacterial meningitis had a mean cerebrospinal fluid lactic dehydrogenase of 251 units on the initial examination; 20 patients with aseptic meningoencephalitis had a mean lactic dehydrogenase activity of 23 units. The difference between the lactic dehydrogenase activity in children with bacterial and aseptic meningitis was highly significant (p < 0.005). The clinical course of the patients studied was reflected by the change in cerebrospinal fluid lactic dehydrogenase activity on serial determinations. Spinal fluid isoenzyme patterns were studied in a few patients with bacterial and non-bacterial central nervous system disorders. This study indicates that the determination of lactic dehydrogenase in spinal fluid is a useful adjunct to other cerebrospinal fluid parameters in the differential diagnosis of central nervous system infections.

scholarly journals Meta-transcriptomic identification of hepatitis B virus in cerebrospinal fluid in patients with central nervous system disease

2019 ◽  
Vol 95 (4) ◽  
pp. 114878 ◽  
Author(s):  
John H.-O. Pettersson ◽  
Geraldine Piorkowski ◽  
Mayfong Mayxay ◽  
Sayaphet Rattanavong ◽  
Manivanh Vongsouvath ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease ◽  
B Virus

scholarly journals Expression of microRNAs in cerebrospinal fluid of dogs with central nervous system disease

2018 ◽  
Vol 60 (1) ◽  
Author(s):  
Katia Marioni-Henry ◽  
Debiao Zaho ◽  
Pablo Amengual-Batle ◽  
Nina Marie Rzechorzek ◽  
Michael Clinton
Keyword(s):  
Central Nervous System ◽  
Cerebrospinal Fluid ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease
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