scholarly journals Intraplacental Gene Therapy with Ad-IGF-1 Corrects Naturally Occurring Rabbit Model of Intrauterine Growth Restriction

2015 ◽  
Vol 26 (3) ◽  
pp. 172-182 ◽  
Author(s):  
Sundeep G. Keswani ◽  
Swathi Balaji ◽  
Anna B. Katz ◽  
Alice King ◽  
Khaled Omar ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Intrauterine Growth Restriction ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Naturally Occurring

Strategies for intra-amniotic administration of fetal therapy in a rabbit model of intrauterine growth restriction

2021 ◽  
pp. 153537022110035
Author(s):  
Mari Kinoshita ◽  
Fàtima Crispi ◽  
Carla Loreiro ◽  
Eduard Gratacós ◽  
Míriam Illa ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Intraperitoneal Injection ◽  
Rabbit Model ◽  
Osmotic Pump ◽  
Growth Restriction ◽  
Technical Failure ◽  
Fetal Therapy ◽  
Amniotic Cavity ◽  
Intrauterine Growth ◽  
Fetal Survival

Intrauterine growth restriction affects up to 10% of all pregnancies, leading to fetal programming with detrimental consequences for lifelong health. However, no therapeutic strategies have so far been effective to ameliorate these consequences. Our previous study has demonstrated that a single dose of nutrients administered into the amniotic cavity, bypassing the often dysfunctional placenta via intra-amniotic administration, improved survival at birth but not birthweight in an intrauterine growth restriction rabbit model. The aim of this study was to further develop an effective strategy for intra-amniotic fetal therapy in an animal model. Intrauterine growth restriction was induced by selective ligation of uteroplacental vessels on one uterine horn of pregnant rabbits at gestational day 25, and fetuses were delivered by cesarean section on GD30. During the five days of intrauterine growth restriction development, three different methods of intra-amniotic administration were used: continuous intra-amniotic infusion by osmotic pump, multiple intra-amniotic injections, and single fetal intraperitoneal injection. Technical feasibility, capability to systematically reach the fetus, and survival and birthweight of the derived offspring were evaluated for each technique. Continuous intra-amniotic infusion by osmotic pump was not feasible owing to the high occurrence of catheter displacement and amnion rupture, while methods using two intra-amniotic injections and one fetal intraperitoneal injection were technically feasible but compromised fetal survival. Taking into account all the numerous factors affecting intra-amniotic fetal therapy in the intrauterine growth restriction rabbit model, we conclude that an optimal therapeutic strategy with low technical failure and positive fetal impact on both survival and birthweight still needs to be found.

scholarly journals Neonatal Neurobehavior and Diffusion MRI Changes in Brain Reorganization Due to Intrauterine Growth Restriction in a Rabbit Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e31497 ◽  
Author(s):  
Elisenda Eixarch ◽  
Dafnis Batalle ◽  
Miriam Illa ◽  
Emma Muñoz-Moreno ◽  
Ariadna Arbat-Plana ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Diffusion Mri ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Brain Reorganization ◽  
Mri Changes ◽  
And Diffusion

Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction

2016 ◽  
Vol 36 (7) ◽  
pp. 628-635 ◽  
Author(s):  
Horacio Figueroa ◽  
Jorge Cifuentes ◽  
Mauricio Lozano ◽  
Cristobal Alvarado ◽  
Claudia Cabezas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Intrauterine Growth Restriction ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Stress Levels ◽  
Oxide Synthase

scholarly journals Long-term reorganization of structural brain networks in a rabbit model of intrauterine growth restriction

NeuroImage ◽  
2014 ◽  
Vol 100 ◽  
pp. 24-38 ◽  
Author(s):  
Dafnis Batalle ◽  
Emma Muñoz-Moreno ◽  
Ariadna Arbat-Plana ◽  
Miriam Illa ◽  
Francesc Figueras ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Brain Networks ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
Structural Brain

scholarly journals In Vivo Detection of Perinatal Brain Metabolite Changes in a Rabbit Model of Intrauterine Growth Restriction (IUGR)

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0131310 ◽  
Author(s):  
Rui V. Simões ◽  
Emma Muñoz-Moreno ◽  
Rodrigo J. Carbajo ◽  
Anna González-Tendero ◽  
Miriam Illa ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Rabbit Model ◽  
Growth Restriction ◽  
Intrauterine Growth ◽  
In Vivo Detection ◽  
Brain Metabolite
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