scholarly journals Systemic Delivery of Oncolytic Adenoviruses Targeting Transforming Growth Factor-β Inhibits Established Bone Metastasis in a Prostate Cancer Mouse Model

2012 ◽  
Vol 23 (8) ◽  
pp. 871-882 ◽  
Author(s):  
Zebin Hu ◽  
Janhavi Gupta ◽  
Zhenwei Zhang ◽  
Helen Gerseny ◽  
Arthur Berg ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Bone Metastasis ◽  
Mouse Model ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Systemic Delivery ◽  
Oncolytic Adenoviruses

scholarly journals Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Virginia Murillo-Garzón ◽  
Irantzu Gorroño-Etxebarria ◽  
Malin Åkerfelt ◽  
Mikael Christer Puustinen ◽  
Lea Sistonen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

127 TREATMENTS WITH DIVERSE ENDOCRINE-DISRUPTING CHEMICALS RESULTED IN THE INHIBITION OF OVARIAN TUMOR PROGRESSION VIA INTERRUPTION OF TRANSFORMING GROWTH FACTOR-β IN IN VITRO AND XENOGRAFTED MOUSE MODELS

2014 ◽  
Vol 26 (1) ◽  
pp. 177
Author(s):  
H.-R. Lee ◽  
R.-E. Go ◽  
K.-C. Choi
Keyword(s):  
Ovarian Cancer ◽  
Growth Factor ◽  
Mouse Model ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mouse Models ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Xenograft Mouse Model

Activated oestrogen receptor (ER) signaling pathway by 17β-estadiol (E2) appeared to suppress transforming growth factor β (TGF-β) signaling pathway by cross-talk with TGF-β components in ER-positive cancer cells. In this study, we further examined the inhibitory effects of alkylphenols, including 4-nonylphenol (NP), 4-otylphenol (OP), bisphenol A (BPA), and benzophenon-1 (BP-1), in TGF-β signaling pathway. The transcriptional and translational levels of TGF-β-related genes were examined by reverse-transcription PCR (RT-PCR), Western blotting analysis in xenografted mouse models of ovarian cancer BG-1 cells. The NP, OP, and BPA induced the expression of snoN, a TGF-β pathway inhibitor. Treatment with NP, BPA, and BP-1 resulted in decreased phosphorylation of Smad3, a downstream target of TGF-β. With these 2 effects, NP and BPA stimulated the proliferation of BG-1 cells via inhibition of the TGF-β signaling pathway. In a xenograft mouse model, transplanted BG-1 ovarian cancer cells showed significantly decreased phosphorylation of Smad3 and increased expression of snoN in the ovarian tumour masses following treatment with E2, NP, or BPA. In parallel with an in vitro model, the expressions of TGF-β signaling pathway were similarly regulated by NP or BPA in a xenograft mouse model, revealing consistent results. Taken together, these results support that NP and BPA may cause the disruption of the TGF-β signaling pathway and increase the risk of oestrogen-dependent cancers such as ovarian cancer. This work was supported by a grant from the Next-Generation BioGreen 21 Program (No. PJ009599), Rural Development Administration, Republic of Korea.

scholarly journals Dysfunctional Transforming Growth Factor-β Receptor II Accelerates Prostate Tumorigenesis in the TRAMP Mouse Model

2009 ◽  
Vol 69 (18) ◽  
pp. 7366-7374 ◽  
Author(s):  
Hong Pu ◽  
Joanne Collazo ◽  
Elisabeth Jones ◽  
Dustin Gayheart ◽  
Shinichi Sakamoto ◽  
...  
Keyword(s):  
Growth Factor ◽  
Mouse Model ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Prostate Tumorigenesis ◽  
Tramp Mouse ◽  
Β Receptor
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