scholarly journals Systemic Delivery of a Novel Liver-Detargeted Oncolytic Adenovirus Causes Reduced Liver Toxicity but Maintains the Antitumor Response in a Breast Cancer Bone Metastasis Model

2011 ◽  
Vol 22 (9) ◽  
pp. 1137-1142 ◽  
Author(s):  
Zhenwei Zhang ◽  
Jeffrey Krimmel ◽  
Zhiling Zhang ◽  
Zebin Hu ◽  
Prem Seth
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Liver Toxicity ◽  
Oncolytic Adenovirus ◽  
Systemic Delivery ◽  
Antitumor Response ◽  
Metastasis Model ◽  
Breast Cancer Bone Metastasis

scholarly journals Conditional Knockdown of Osteopontin Inhibits Breast Cancer Skeletal Metastasis

2019 ◽  
Vol 20 (19) ◽  
pp. 4918 ◽  
Author(s):  
Marineta Kovacheva ◽  
Michael Zepp ◽  
Muriel Schraad ◽  
Stefan Berger ◽  
Martin R. Berger
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Skeletal Metastasis ◽  
Skeletal Metastases ◽  
Specific Gene ◽  
Cell Clones ◽  
Gene And Protein Expression ◽  
Metastasis Model ◽  
Breast Cancer Bone Metastasis

High osteopontin (OPN) expression is linked to breast cancer bone metastasis. In this study we modulated osteopontin levels conditionally and investigated any related antineoplastic effects. Therefore, we established cell clones from human breast cancer MDA-MB-231 cells, in which the expression of OPN is regulated by the Tet-Off tet-off system. These cells, which conditionally express a specific miRNA targeting OPN, were used for in vitro studies as well as for a bone metastasis model in nude rats. Changes in whole-genome expression elicited by conditional OPN knockdown and vesicle formation were also analyzed. The alkylphosphocholine erufosine was used for combination therapy. Conditional OPN knockdown caused mild anti-proliferative, but more intensive anti-migratory and anti clonogenic effects, as well as partial and complete remissions of soft tissue and osteolytic lesions. These effects were associated with specific gene and protein expression modulations following miRNA-mediated OPN knockdown. Furthermore, high levels of OPN were detected in vesicles derived from rats harboring breast cancer skeletal metastases. Finally, the combination of OPN inhibition and erufosine treatment caused an additive reduction of OPN levels in the investigated breast cancer cells. Thus, knockdown of OPN alone or in combination with erufosine is a promising strategy in breast cancer skeletal metastasis treatment.

SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model

2003 ◽  
Vol 20 (8) ◽  
pp. 757-766 ◽  
Author(s):  
Lesley J. Murray ◽  
Tinya J. Abrams ◽  
Kelly R. Long ◽  
Theresa J. Ngai ◽  
Lisa M. Olson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Tumor Growth ◽  
Metastasis Model ◽  
Breast Cancer Bone Metastasis

Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis

2008 ◽  
Vol 68 (S 01) ◽  
Author(s):  
C Schem ◽  
DO Bauerschlag ◽  
J Weimer ◽  
M Zhang ◽  
W Jonat ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastasis ◽  
Breast Cancer Bone Metastasis ◽  
Cox2 Expression
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