Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma

2011 ◽  
Vol 22 (11) ◽  
pp. 1365-1377 ◽  
Author(s):  
Xiao Ying Bak ◽  
Hoang Lam Dang ◽  
Jingye Yang ◽  
Kai Ye ◽  
Esther X.W. Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Gene Therapy ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Cellular Delivery ◽  
Delivery Vehicles

scholarly journals Accelerated Wound Healing by Fibroblasts Differentiated from Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells in a Pressure Ulcer Animal Model

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Dajeong Yoon ◽  
Dogeon Yoon ◽  
Heejoong Sim ◽  
Inseok Hwang ◽  
Ji-Seon Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Pressure Ulcer ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Type I ◽  
Skin Ulcers

Fibroblasts synthesize and secrete dermal collagen, matrix proteins, growth factors, and cytokines. These characteristics of fibroblasts provide a potential way for fibroblast therapy to treat skin ulcers more effectively than conventional therapies such as cytokine therapy and negative pressure wound therapy. However, the obstacle to the commercialization of fibroblast therapy is the limited supply of cells with consistent quality. In this study, we tested whether human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) could be differentiated into fibroblasts considering that they have characteristics of high differentiation rates, unlimited proliferation possibility from a single colony, and homogeneity. As a result, hESC-MSC-derived fibroblasts (hESC-MSC-Fbs) showed a significant increase in the expression of type I and III collagen, fibronectin, and fibroblast-specific protein-1 (FSP-1). Besides, vessel formation and wound healing were enhanced in hESC-MSC-Fb-treated skin tissues compared to PBS- or hESC-MSC-treated skin tissues, along with decreased IL-6 expression at 4 days after the formation of pressure ulcer wound in a mouse model. In view of the limited available cell sources for fibroblast therapy, hESC-MSC-Fbs show a promising potential as a commercial cell therapy source to treat skin ulcers.

Efficient Engineering of Vascularized Ectopic Bone from Human Embryonic Stem Cell–Derived Mesenchymal Stem Cells

2012 ◽  
Vol 18 (21-22) ◽  
pp. 2290-2302 ◽  
Author(s):  
Hagit Domev ◽  
Michal Amit ◽  
Ilana Laevsky ◽  
Ayelet Dar ◽  
Joseph Itskovitz-Eldor
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Ectopic Bone

scholarly journals Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells

2007 ◽  
Vol 6 (10) ◽  
pp. 1680-1689 ◽  
Author(s):  
Siu Kwan Sze ◽  
Dominique P. V. de Kleijn ◽  
Ruenn Chai Lai ◽  
Eileen Khia Way Tan ◽  
Hui Zhao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem

scholarly journals Human embryonic stem cell-derived mesenchymal stem cells improved premature ovarian failure

2020 ◽  
Vol 12 (8) ◽  
pp. 857-878
Author(s):  
Khadijeh Bahrehbar ◽  
Mojtaba Rezazadeh Valojerdi ◽  
Fereshteh Esfandiari ◽  
Rouhollah Fathi ◽  
Seyedeh-Nafiseh Hassani ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Premature Ovarian Failure ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Ovarian Failure
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