scholarly journals Genetic Engineering of Mesenchymal Stem Cells and Its Application in Human Disease Therapy

2010 ◽  
Vol 21 (11) ◽  
pp. 1513-1526 ◽  
Author(s):  
Conrad P. Hodgkinson ◽  
José A. Gomez ◽  
Maria Mirotsou ◽  
Victor J. Dzau
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Genetic Engineering ◽  
Human Disease ◽  
Disease Therapy

Intranasal administration of endometrial mesenchymal stem cells as a suitable approach for Parkinson’s disease therapy

2019 ◽  
Vol 46 (4) ◽  
pp. 4293-4302 ◽  
Author(s):  
Saeid Bagheri-Mohammadi ◽  
Behrang Alani ◽  
Mohammad Karimian ◽  
Rana Moradian-Tehrani ◽  
Mahdi Noureddini
Keyword(s):  
Parkinson’S Disease ◽  
Stem Cells ◽  
Parkinson's Disease ◽  
Mesenchymal Stem Cells ◽  
Intranasal Administration ◽  
Disease Therapy

Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine

2015 ◽  
Vol 24 (19) ◽  
pp. 2219-2242 ◽  
Author(s):  
Adam Nowakowski ◽  
Piotr Walczak ◽  
Miroslaw Janowski ◽  
Barbara Lukomska
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Genetic Engineering

scholarly journals More to Explore; The Mesenchymal Stem Cells (MSCs) Major Tissue Sources, Known Surface Markers, and Its Immunomodulation properties

2021 ◽  
pp. 85-97
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Modulation ◽  
Molecular Mechanisms ◽  
Cell Types ◽  
Surface Markers ◽  
Differentiation Potential ◽  
Disease Therapy ◽  
Multipotent Progenitor Cells ◽  
Mesodermal Origin

Mesenchymal stem cells (MSCs) are currently available for a range of applications and have become a good material for regenerative medicine, tissue engineering, and disease therapy. MSCs are self-renewing, multipotent progenitor cells with multilineage potential to differentiate into cell types of mesodermal origin, such as adipocytes, osteocytes, and chondrocytes, and exert potent immunosuppressive potentials. In the present review, we highlight the currently reported variations in the differentiation potential of MSCs from different tissue sources, the minimal criteria to define MSCs from various tissue environments, and provide a detailed description of MSCs surface markers. Furthermore, MSC's immunomodulatory features secrete cytokines and immune receptors which regulate the microenvironment in the host tissue also revisits in detail. We propose that there are likely more sources of MSCs waiting to be discovered. We need to Standardize MSCs characterization by selecting markers for isolation, cellular and molecular mechanisms involved in MSC-mediated immune modulation, and other functionalities of MSCs should be characterized prior to use in clinical applications.

scholarly journals Genetic engineering of mesenchymal stem cells by non-viral gene delivery

2014 ◽  
Vol 58 (1) ◽  
pp. 19-48 ◽  
Author(s):  
Weiwei Wang ◽  
Xun Xu ◽  
Zhengdong Li ◽  
Andreas Lendlein ◽  
Nan Ma
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Gene Delivery ◽  
Genetic Engineering ◽  
Viral Gene ◽  
Viral Gene Delivery
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