scholarly journals Rapid Production of Clinical-Grade Gammaretroviral Vectors in Expanded Surface Roller Bottles Using a “Modified” Step-Filtration Process for Clearance of Packaging Cells

2011 ◽  
Vol 22 (1) ◽  
pp. 107-115 ◽  
Author(s):  
Steven A. Feldman ◽  
Stephanie L. Goff ◽  
Hui Xu ◽  
Mary A. Black ◽  
James N. Kochenderfer ◽  
...  
Keyword(s):  
Clinical Grade ◽  
Filtration Process ◽  
Rapid Production ◽  
Roller Bottles

scholarly journals Rapid production of clinical‐grade SARS‐CoV‐2 specific T cells

2020 ◽  
Vol 3 (4) ◽  
Author(s):  
Wing Leung ◽  
Teck Guan Soh ◽  
Yeh Ching Linn ◽  
Jenny Guek‐Hong Low ◽  
Jiashen Loh ◽  
...  
Keyword(s):  
T Cells ◽  
Clinical Grade ◽  
Rapid Production

SOUTH AFRICA IN THE CINEMATIC IMAGINARY: THE STORY OF A WHITE YOUTH IN SKIN

2017 ◽  
Vol 14 (2) ◽  
pp. 170-178
Author(s):  
Khatija Bibi Khan
Keyword(s):  
South Africa ◽  
Spiritual Development ◽  
Black People ◽  
White Youth ◽  
Multiple Selves ◽  
Social Imaginaries ◽  
South Africans ◽  
Rapid Production ◽  
New Critics ◽  
Good Number

The rapid production of films of diversity in post-1994 South Africa has unfortunately not been matched by critical works on film. Part of the reason is that some of the films recycle old themes that celebrate the worst in black people. Another possible reason could be that a good number of films wallow in personality praise, and certainly of Mandela, especially after his demise. Despite these problems of film criticism in post-1994 South Africa, it appears that some new critics have not felt compelled to waste their energy on analysing the Bantustan film – a kind of film that was made for black people by the apartheid system but has re-surfaced after 1994 in different ways. The patent lack of more critical works on film that engages the identities and social imaginaries of young and white South Africans is partly addressed in SKIN – a film that registers the mental growth and spiritual development of Sandra’s multiple selves. This article argues that SKIN portrays the racial neurosis of the apartheid system; and the question of identity affecting young white youths during and after apartheid is experienced at the racial, gender and sex levels.

METHODS AND ALGORITHMS FOR THE COMPLETE PROCESSING OF A POSTDETECTOR LOW-CONTRAST OPTICAL IMAGE

2018 ◽  
pp. 99-107
Author(s):  
V. V. Lavrov ◽  
R. S. Luchkin ◽  
O. I. Nemykin ◽  
M. E. Prokhorov ◽  
Yu. G. Ryndin ◽  
...  
Keyword(s):  
Optical Image ◽  
Structural Elements ◽  
Filtration Process ◽  
Low Contrast ◽  
Information Object ◽  
Detection Stage ◽  
Metric Structures ◽  
Spot 5 ◽  
Integrated Indicators ◽  
Complete Processing

Methods and algorithms for the complete processing of a post-detector low-contrast optical image (OI) of an unknown remote object obtained by ground-based optical means of observation under conditions of a complex background situation are considered. The purpose of processing is to separate and interpret at least with the help of the analyst, of the main constructive elements using the integrated indicators introduced in [6] and the characteristics of the analyzed OI, which are connected by the information, topological and metric structures of the OI. The stages of processing the OI include extracting the image-containing information object of the image portion (detection) and filtration of the OI, using recursive rank filtering. The final stages of processing include the segmentation of the OI and the allocation on it constructive elements using the apparatus of graph theory. An example of image processing of a Spot-5 spacecraft obtained in real conditions is given. It is shown that in this case at the detection stage it is possible to reduce the volume of information processed at subsequent stages by 8 times, in the filtration process to increase the compactness of the OI and to increase its connectivity in comparison with the post-detection OI. As a result of segmentation and allocation of constructive elements, three structural elements that can be interpreted as a spacecraft case and two remote panels can be identified with the analyst’s participation.

scholarly journals Clinical-grade whole-genome sequencing and 3′ transcriptome analysis of colorectal cancer patients

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Agata Stodolna ◽  
Miao He ◽  
Mahesh Vasipalli ◽  
Zoya Kingsbury ◽  
Jennifer Becq ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Transcriptome Analysis ◽  
Variant Calling ◽  
Standard Of Care ◽  
Genomic Variation ◽  
Whole Genome ◽  
Clinical Grade ◽  
Pathway Gene

Abstract Background Clinical-grade whole-genome sequencing (cWGS) has the potential to become the standard of care within the clinic because of its breadth of coverage and lack of bias towards certain regions of the genome. Colorectal cancer presents a difficult treatment paradigm, with over 40% of patients presenting at diagnosis with metastatic disease. We hypothesised that cWGS coupled with 3′ transcriptome analysis would give new insights into colorectal cancer. Methods Patients underwent PCR-free whole-genome sequencing and alignment and variant calling using a standardised pipeline to output SNVs, indels, SVs and CNAs. Additional insights into the mutational signatures and tumour biology were gained by the use of 3′ RNA-seq. Results Fifty-four patients were studied in total. Driver analysis identified the Wnt pathway gene APC as the only consistently mutated driver in colorectal cancer. Alterations in the PI3K/mTOR pathways were seen as previously observed in CRC. Multiple private CNAs, SVs and gene fusions were unique to individual tumours. Approximately 30% of patients had a tumour mutational burden of > 10 mutations/Mb of DNA, suggesting suitability for immunotherapy. Conclusions Clinical whole-genome sequencing offers a potential avenue for the identification of private genomic variation that may confer sensitivity to targeted agents and offer patients new options for targeted therapies.

scholarly journals Rapid production of bicontinuous macroporous materials using intrinsically polymerizable bijels

2021 ◽  
Author(s):  
Herman Ching ◽  
Todd J Thorson ◽  
Brian Paul ◽  
Ali Mohraz
Keyword(s):  
Energy Storage ◽  
Electrochemical Energy Storage ◽  
Morphological Attributes ◽  
Macroporous Materials ◽  
Rapid Production ◽  
Processing Techniques ◽  
Electrochemical Energy

The discovery of bicontinuous interfacially jammed emulsion gels (bijels) in 2007 motivated the development of processing techniques to harness their unique morphological attributes in applications such as electrochemical energy storage...

Sign in / Sign up

Export Citation Format

Share Document