scholarly journals Magnetic Resonance Imaging-Guided Delivery of Adeno-Associated Virus Type 2 to the Primate Brain for the Treatment of Lysosomal Storage Disorders

2010 ◽  
Vol 21 (9) ◽  
pp. 1093-1103 ◽  
Author(s):  
E. Aguilar Salegio ◽  
A.P. Kells ◽  
R.M. Richardson ◽  
P. Hadaczek ◽  
J. Forsayeth ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Virus Type ◽  
Lysosomal Storage Disorders ◽  
Lysosomal Storage ◽  
Resonance Imaging ◽  
Adeno Associated Virus ◽  
Primate Brain ◽  
Storage Disorders

scholarly journals Serial magnetic resonance imaging findings during severe attacks of familial hemiplegic migraine type 2: a case report

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
David Fear ◽  
Misha Patel ◽  
Ramin Zand
Keyword(s):  
Magnetic Resonance Imaging ◽  
Family History ◽  
Magnetic Resonance ◽  
Familial Hemiplegic Migraine ◽  
Imaging Findings ◽  
Resonance Imaging ◽  
Hemiplegic Migraine ◽  
Magnetic Resonance Imaging Mri ◽  
Mri Changes

Abstract Background Hemiplegic migraines represent a heterogeneous disorder with various presentations. Hemiplegic migraines are classified as sporadic or familial based on the presence of family history, but both subtypes have an underlying genetic etiology. Mutations in the ATP1A2 gene are responsible for Familial Hemiplegic type 2 (FHM2) or the sporadic hemiplegic migraine (SHM) counterpart if there is no family history of the disorder. Manifestations include migraine with aura and hemiparesis along with a variety of other symptoms likely dependent upon the specific mutation(s) present. Case presentation We report the case of an adult man who presented with headache, aphasia, and right-sided weakness. Workup for stroke and various infectious agents was unremarkable during the patient’s extended hospital stay. We emphasize the changes in the Magnetic Resonance Imaging (MRI) over time and the delay from onset of symptoms to MRI changes in Isotropic Diffusion Map (commonly referred to as Diffusion Weighted Imaging (DWI)) as well as Apparent Diffusion Coefficient (ADC). Conclusions We provide a brief review of imaging findings correlated with signs/symptoms and specific mutations in the ATP1A2 gene reported in the literature. Description of the various mutations and consequential presentations may assist neurologists in identifying cases of Hemiplegic Migraine, which may include transient changes in ADC and DWI imaging throughout the course of an attack.

P75 SIGNS OF ACCELERATED CAROTID ATHEROSCLEROSIS IN EARLY TYPE 2 DIABETES ASSESSED BY MAGNETIC RESONANCE IMAGING

2017 ◽  
Vol 20 (C) ◽  
pp. 74
Author(s):  
Esben Laugesen ◽  
Pernille Høyem ◽  
Samuel Thrysøe ◽  
Esben Hansen ◽  
Anders Mikkelsen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Type 2 Diabetes ◽  
Magnetic Resonance ◽  
Carotid Atherosclerosis ◽  
Early Type ◽  
Resonance Imaging

scholarly journals Identifying Type 2 Diabetic Brains by Investigating Disease-Related Structural Changes in Magnetic Resonance Imaging

2021 ◽  
Vol 15 ◽  
Author(s):  
Yuna Chen ◽  
Yongsheng Pan ◽  
Shangyu Kang ◽  
Junshen Lu ◽  
Xin Tan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Brain Structure ◽  
Brain Mri ◽  
Brain Diseases ◽  
Imaging Biomarkers ◽  
Resonance Imaging ◽  
High Blood Glucose ◽  
The Brain

Diabetes with high blood glucose levels may damage the brain nerves and thus increase the risk of dementia. Previous studies have shown that dementia can be reflected in altered brain structure, facilitating computer-aided diagnosis of brain diseases based on structural magnetic resonance imaging (MRI). However, type 2 diabetes mellitus (T2DM)-mediated changes in the brain structures have not yet been studied, and only a few studies have focused on the use of brain MRI for automated diagnosis of T2DM. Hence, identifying MRI biomarkers is essential to evaluate the association between changes in brain structure and T2DM as well as cognitive impairment (CI). The present study aims to investigate four methods to extract features from MRI, characterize imaging biomarkers, as well as identify subjects with T2DM and CI.

Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain

2005 ◽  
Vol 196 (2) ◽  
pp. 381-389 ◽  
Author(s):  
Ryuta Saito ◽  
Michal T. Krauze ◽  
John R. Bringas ◽  
Charles Noble ◽  
Tracy R. McKnight ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Real Time ◽  
Resonance Imaging ◽  
Convection Enhanced Delivery ◽  
Primate Brain
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