scholarly journals Mitochondrial Gene Therapy Augments Mitochondrial Physiology in a Parkinson's Disease Cell Model

2009 ◽  
Vol 20 (8) ◽  
pp. 897-907 ◽  
Author(s):  
Paula M. Keeney ◽  
Caitlin K. Quigley ◽  
Lisa D. Dunham ◽  
Christina M. Papageorge ◽  
Shilpa Iyer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Gene Therapy ◽  
Parkinson's Disease ◽  
Cell Model ◽  
Mitochondrial Gene ◽  
Disease Cell

scholarly journals Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson's disease

2020 ◽  
Vol 40 (6) ◽  
Author(s):  
Jiahui Liu ◽  
Hong Liu ◽  
Zhenxiang Zhao ◽  
Jianfeng Wang ◽  
Dandan Guo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Model ◽  
Cell Damage ◽  
Glutathione S Transferase ◽  
Expression Arrays ◽  
Transcriptional Changes ◽  
Molecular Mechanism Of Action ◽  
Disease Cell

Abstract The present study aimed to identify the gene expression changes conferred by capsaicin in the cell model of 6-OHDA-induced Parkinson's disease, to disclose the molecular mechanism of action of capsaicin. We used capsaicin-treated and paraffin-embedded wax blocks containing substantia nigra tissue from 6-OHDA-induced Parkinson's disease rats to analyze transcriptional changes using Affymetrix GeneChip Whole Transcript Expression Arrays. A total of 108 genes were differentially expressed in response to capsaicin treatment, and seven of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1 (actin gamma 1) was down-regulated and Gsta2 (Glutathione S-transferase alpha 2) was up-regulated. We successfully overexpressed Actg1 and Gsta2 in vitro. CCK-8 detection and flow cytometry demonstrated that overexpression of Actg1 and Gsta2 increased apoptosis in the 6-OHDA-induced Parkinson's disease cell model. The imbalance between Actg1 and Gsta2 may be one of the mechanisms of cell damage in Parkinson's disease (PD). Capsaicin can protect the cells and reduce the apoptosis rate by regulating Actg1 and Gsta2.

scholarly journals Nur77 attenuates inflammatory responses and oxidative stress by inhibiting phosphorylated IκB-α in Parkinson’s disease cell model

Aging ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 8107-8119
Author(s):  
Junqiang Yan ◽  
Jiarui Huang ◽  
Jiannan Wu ◽  
Hua Fan ◽  
Anran Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Inflammatory Responses ◽  
Cell Model ◽  
Disease Cell ◽  
And Oxidative Stress

scholarly journals Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

2010 ◽  
Vol 11 (1) ◽  
pp. 57 ◽  
Author(s):  
Min S Wang ◽  
Shanta Boddapati ◽  
Sharareh Emadi ◽  
Michael R Sierks
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Model ◽  
Disease Cell
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