Gene-Eluting Stents: Comparison of Adenoviral and Adeno- Associated Viral Gene Delivery to the Blood Vessel Wall In Vivo

2006 ◽  
Vol 17 (7) ◽  
pp. 741-750 ◽  
Author(s):  
Faisal Sharif ◽  
Sean O. Hynes ◽  
Jill McMahon ◽  
Ronan Cooney ◽  
Siobhan Conroy ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Blood Vessel ◽  
Vessel Wall ◽  
Viral Gene ◽  
Blood Vessel Wall ◽  
Viral Gene Delivery

Gene-Eluting Stents: Comparison of Adenoviral and Adeno- Associated Viral Gene Delivery to the Blood Vessel Wall In Vivo

2006 ◽  
Vol 0 (0) ◽  
pp. 060801084750030
Author(s):  
Faisal Sharif ◽  
Sean O. Hynes ◽  
Jill McMahon ◽  
Ronan Cooney ◽  
Siobhan Conroy ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Blood Vessel ◽  
Vessel Wall ◽  
Viral Gene ◽  
Blood Vessel Wall ◽  
Viral Gene Delivery

Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall

Blood ◽  
2005 ◽  
Vol 105 (1) ◽  
pp. 192-198 ◽  
Author(s):  
Sharlene M. Day ◽  
Jennifer L. Reeve ◽  
Brian Pedersen ◽  
Diana M Farris ◽  
Daniel D. Myers ◽  
...  
Keyword(s):  
Blood Vessel ◽  
Tissue Factor ◽  
Vessel Wall ◽  
Thrombus Formation ◽  
Vena Cava ◽  
Vascular Wall ◽  
Blood Vessel Wall ◽  
Wild Type

Abstract Leukocytes and leukocyte-derived microparticles contain low levels of tissue factor (TF) and incorporate into forming thrombi. Although this circulating pool of TF has been proposed to play a key role in thrombosis, its functional significance relative to that of vascular wall TF is poorly defined. We tested the hypothesis that leukocyte-derived TF contributes to thrombus formation in vivo. Compared to wild-type mice, mice with severe TF deficiency (ie, TF–/–, hTF-Tg+, or “low-TF”) demonstrated markedly impaired thrombus formation after carotid artery injury or inferior vena cava ligation. A bone marrow transplantation strategy was used to modulate levels of leukocyte-derived TF. Transplantation of low-TF marrow into wild-type mice did not suppress arterial or venous thrombus formation. Similarly, transplantation of wild-type marrow into low-TF mice did not accelerate thrombosis. In vitro analyses revealed that TF activity in the blood was very low and was markedly exceeded by that present in the vessel wall. Therefore, our results suggest that thrombus formation in the arterial and venous macrovasculature is driven primarily by TF derived from the blood vessel wall as opposed to leukocytes.

scholarly journals 921. In Vivo Non Viral Gene Delivery of BMP-9 Regenerates Non Union Bone Defect

2006 ◽  
Vol 13 ◽  
pp. S355-S356
Author(s):  
Nadav Kimelman ◽  
Gadi Pelled ◽  
Yoram Zilberman ◽  
Evellin Zeira ◽  
Hagit Yotvat ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Bone Defect ◽  
Viral Gene ◽  
Non Union ◽  
Viral Gene Delivery
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