Protein Scaffold and Expression Level Determine Antiviral Activity of Membrane-Anchored Antiviral Peptides

2009 ◽  
Vol 20 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Felix G. Hermann ◽  
Holger Martinius ◽  
Marc Egelhofer ◽  
Tsanan Giroglou ◽  
Torsten Tonn ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Expression Level ◽  
Protein Scaffold ◽  
Antiviral Peptides

Protein Scaffold and Expression Level Determine Antiviral Activity of Membrane-Anchored Antiviral Peptides

2008 ◽  
Vol 0 (ja) ◽  
pp. 081229064610067 ◽  
Author(s):  
Felix Günter Hermann ◽  
Holger Martinius ◽  
Marc Egelhofer ◽  
Tsanan Giroglou ◽  
Torston Tonn ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Expression Level ◽  
Protein Scaffold ◽  
Antiviral Peptides

scholarly journals Scorpion-Derived Antiviral Peptides with a Special Focus on Medically Important Viruses: An Update

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Moulay Abdelmonaim El Hidan ◽  
Mehdi Ait Laaradia ◽  
Omar El Hiba ◽  
Ahmed Draoui ◽  
Abdelmohcine Aimrane ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Viral Infection ◽  
Bioactive Peptides ◽  
Biomedical Application ◽  
Scorpion Venom ◽  
Global Burden ◽  
Special Focus ◽  
Modes Of Action ◽  
Medical Issues ◽  
Antiviral Peptides

The global burden of viral infection, especially the current pandemics of SARS-CoV-2, HIV/AIDS, and hepatitis, is a very risky one. Additionally, HCV expresses the necessity for antiviral therapeutic elements. Venoms are known to contain an array of bioactive peptides that are commonly used in the treatment of various medical issues. Several peptides isolated from scorpion venom have recently been proven to possess an antiviral activity against several viral families. The aim of this review is to provide an up-to-date overview of scorpion antiviral peptides and to discuss their modes of action and potential biomedical application against different viruses.

scholarly journals A Novel Digestive Proteinase Lipase Member H-A in Bombyx mori Contributes to Digestive Juice Antiviral Activity against B. mori Nucleopolyhedrovirus

Insects ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 154 ◽  
Author(s):  
Shang-Zhi Zhang ◽  
Lin-Bao Zhu ◽  
Ling-Ling You ◽  
Jie Wang ◽  
Hui-Hua Cao ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Bombyx Mori ◽  
Treated Group ◽  
Middle Part ◽  
Expression Level ◽  
Label Free ◽  
Proteomics Data ◽  
Gene Encoding ◽  
Digestive Juice ◽  
Bmn Cells

Previous studies have revealed that some proteins in Bombyx mori larvae digestive juice show antiviral activity. Here, based on the label-free proteomics data, BmLipase member H-A (BmLHA) was identified as being involved in the response to BmNPV infection in B. mori larvae digestive juice. In the present study, a gene encoding the BmLHA protein in B. mori was characterized. The protein has an open reading fragment of 999 bp, encoding a predicted 332 amino acid residue-protein with a molecular weight of approximately 35.9 kDa. The phylogenetic analysis revealed that BmLHA shares a close genetic distance with Papilio xuthus Lipase member H-A. BmLHA was highly expressed in the middle part of the B. mori gut, and the expression level increased with instar rising in larvae. There was higher expression of BmLHA in A35 than in P50 strains, and it was upregulated in both A35 and P50 strains, following BmNPV infection. The expression level of VP39 decreased significantly in appropriate recombinant-BmLHA-treated groups compared with the PBS-treated group in B. mori larvae and BmN cells. Meanwhile, overexpression of BmLHA significantly reduced the infectivity of BmNPV in BmN cells. These results indicated that BmLHA did not have digestive function but had anti-BmNPV activity. Taken together, our work provides valuable data for the clarification of the molecular characterization BmLHA and supplements research on proteins of anti-BmNPV activity in B. mori.

The Antiviral Activity of the CXCR4 Antagonist AMD3100 Is Independent of the Cytokine-Induced CXCR4/HIV Coreceptor Expression Level

2003 ◽  
Vol 19 (12) ◽  
pp. 1135-1139 ◽  
Author(s):  
Katrien Princen ◽  
Sigrid Hatse ◽  
Kurt Vermeire ◽  
Gary J. Bridger ◽  
Renato T. Skerlj ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Expression Level ◽  
Cxcr4 Antagonist

Antiviral activity of EPs® 7630 as assessed in a fibroblast-virus protection assay

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
C Thaele ◽  
A Janecki ◽  
AF Kiderlen ◽  
H Kolodziej
Keyword(s):  
Antiviral Activity ◽  
Protection Assay
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