Neuroprotective Gene Therapy for Huntington's Disease, Using Polymer-Encapsulated Cells Engineered to Secrete Human Ciliary Neurotrophic Factor: Results of a Phase I Study

2004 ◽  
Vol 15 (10) ◽  
pp. 968-975 ◽  
Author(s):  
J. Bloch ◽  
A.C. Bachoud-Lévi ◽  
N. Déglon ◽  
J.P. Lefaucheur ◽  
L. Winkel ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Phase I ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophic Factor ◽  
Phase I Study ◽  
Ciliary Neurotrophic Factor ◽  
Encapsulated Cells

scholarly journals Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

2004 ◽  
Vol 185 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Diana Zala ◽  
Jean-Charles Bensadoun ◽  
Luis Pereira de Almeida ◽  
Blair R. Leavitt ◽  
Claire-Anne Gutekunst ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor

Homozygotes and heterozygotes for ciliary neurotrophic factor null alleles do not show earlier onset of Huntington's disease

Neurology ◽  
1997 ◽  
Vol 49 (3) ◽  
pp. 890-892 ◽  
Author(s):  
D. C. Rubinsztein ◽  
J. Leggo ◽  
M. Chiano ◽  
S. Korn ◽  
A. Dodge ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Null Alleles

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease

Nature ◽  
1997 ◽  
Vol 386 (6623) ◽  
pp. 395-399 ◽  
Author(s):  
Dwaine F. Emerich ◽  
Shelley R. Winn ◽  
Philippe M. Hantraye ◽  
Marc Peschanski ◽  
Er-Yun Chen ◽  
...  
Keyword(s):  
Protective Effect ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophic Factor ◽  
Encapsulated Cells ◽  
Monkey Model

Restoration of Cognitive and Motor Functions by Ciliary Neurotrophic Factor in a Primate Model of Huntington's Disease

2000 ◽  
Vol 11 (8) ◽  
pp. 1177-1188 ◽  
Author(s):  
Vincent Mittoux ◽  
Jean-Marc Joseph ◽  
Françoise Conde ◽  
Stephane Palfi ◽  
Caroline Dautry ◽  
...  
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Neurotrophic Factor ◽  
Ciliary Neurotrophic Factor ◽  
Primate Model ◽  
Motor Functions
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