Effect of Oral Vitamin C Supplementation on High-Altitude Hyperuricemia in Young Men Initially Migrating to High Altitude: A Pilot Study

2018 ◽  
Vol 19 (4) ◽  
pp. 373-381
Author(s):  
Hui Peng ◽  
Dongfang Feng ◽  
Yingkai Wang ◽  
Zixi Dong ◽  
Qing Chen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Vitamin C ◽  
High Altitude ◽  
Young Men ◽  
Oral Vitamin ◽  
Vitamin C Supplementation

scholarly journals Effects of oral vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients

2005 ◽  
Vol 20 (9) ◽  
pp. 1874-1879 ◽  
Author(s):  
Christine Fumeron ◽  
Thao Nguyen-Khoa ◽  
Claudine Saltiel ◽  
Messeret Kebede ◽  
Claude Buisson ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Oral Vitamin ◽  
Vitamin C Supplementation

scholarly journals Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Linn Gillberg ◽  
Andreas D. Ørskov ◽  
Ammar Nasif ◽  
Hitoshi Ohtani ◽  
Zachary Madaj ◽  
...  
Keyword(s):  
Vitamin C ◽  
Biological Effects ◽  
Pilot Trial ◽  
Dna Demethylation ◽  
Controlled Clinical Trial ◽  
Plasma Vitamin ◽  
Oral Vitamin ◽  
Oral Supplementation ◽  
Vitamin C Deficiency ◽  
Vitamin C Supplementation

Abstract Background Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in active DNA demethylation. Here, we investigate whether oral vitamin C supplementation can correct vitamin C deficiency and affect the 5hmC/5mC ratio in patients with myeloid cancers treated with DNA methyltransferase inhibitors (DNMTis). Results We conducted a randomized, double-blinded, placebo-controlled pilot trial (NCT02877277) in Danish patients with myeloid cancers performed during 3 cycles of DNMTi-treatment (5-azacytidine, 100 mg/m2/d for 5 days in 28-day cycles) supplemented by oral dose of 500 mg vitamin C (n = 10) or placebo (n = 10) daily during the last 2 cycles. Fourteen patients (70%) were deficient in plasma vitamin C (< 23 μM) and four of the remaining six patients were taking vitamin supplements at inclusion. Global DNA methylation was significantly higher in patients with severe vitamin C deficiency (< 11.4 μM; 4.997 vs 4.656% 5mC relative to deoxyguanosine, 95% CI [0.126, 0.556], P = 0.004). Oral supplementation restored plasma vitamin C levels to the normal range in all patients in the vitamin C arm (mean increase 34.85 ± 7.94 μM, P = 0.0004). We show for the first time that global 5hmC/5mC levels were significantly increased in mononuclear myeloid cells from patients receiving oral vitamin C compared to placebo (0.037% vs − 0.029%, 95% CI [− 0.129, − 0.003], P = 0.041). Conclusions Normalization of plasma vitamin C by oral supplementation leads to an increase in the 5hmC/5mC ratio compared to placebo-treated patients and may enhance the biological effects of DNMTis. The clinical efficacy of oral vitamin C supplementation to DNMTis should be investigated in a large randomized, placebo-controlled clinical trial. Trial registration ClinicalTrials.gov, NCT02877277. Registered on 9 August 2016, retrospectively registered.

Long-term effects of oral vitamin C supplementation on the endothelial dysfunction in the iris microvessels of diabetic rats

2007 ◽  
Vol 74 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Amporn Jariyapongskul ◽  
Tippawan Rungjaroen ◽  
Ngamjit Kasetsuwan ◽  
Suthiluk Patumraj ◽  
Junji Seki ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Vitamin C ◽  
Diabetic Rats ◽  
Long Term Effects ◽  
Oral Vitamin ◽  
Vitamin C Supplementation

Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial

2014 ◽  
Vol 18 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Ivaldo Jesus Lima de Oliveira ◽  
Victor Vasconcelos de Souza ◽  
Vitor Motta ◽  
Sergio Leme Da-Silva
Keyword(s):  
Vitamin C ◽  
Controlled Trial ◽  
Oral Vitamin ◽  
Double Blind ◽  
Vitamin C Supplementation

scholarly journals Ascorbic acid concentrations in aqueous humor after systemic vitamin C supplementation in patients with cataract: pilot study

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Young-Sool Hah ◽  
Hye Jin Chung ◽  
Sneha B. Sontakke ◽  
In-Young Chung ◽  
Sunmi Ju ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Pilot Study ◽  
Vitamin C ◽  
Aqueous Humor ◽  
Vitamin C Supplementation
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