Effects of Chronic Ghrelin Treatment on Hypoxia-Induced Brain Oxidative Stress and Inflammation in a Rat Normobaric Chronic Hypoxia Model

2017 ◽  
Vol 18 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Hasan Omrani ◽  
Mohammad Reza Alipour ◽  
Fereshteh Farajdokht ◽  
Hadi Ebrahimi ◽  
Mehran Mesgari Abbasi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Hypoxia ◽  
Brain Oxidative Stress

scholarly journals Feasibility of 3-month melatonin supplementation for brain oxidative stress and sleep in mild cognitive impairment: protocol for a randomised, placebo-controlled study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041500
Author(s):  
Zoe Menczel Schrire ◽  
Craig L Phillips ◽  
Shantel L Duffy ◽  
Nathaniel S Marshall ◽  
Loren Mowszowski ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Feasibility Trial ◽  
Controlled Study ◽  
Brain Oxidative Stress ◽  
Randomised Controlled

IntroductionMelatonin has multiple proposed therapeutic benefits including antioxidant properties, synchronisation of the circadian system and lowering of blood pressure. In this protocol, we outline a randomised controlled trial to assess the feasibility, acceptability and tolerability of higher dose (25 mg) melatonin to target brain oxidative stress and sleep disturbance in older adults with mild cognitive impairment (MCI).Methods and analysisThe study design is a randomised double-blind, placebo-controlled, parallel group trial. Forty individuals with MCI will be recruited from the Healthy Brain Ageing Clinic, University of Sydney and from the community, and randomised to receive either 25 mg oral melatonin or placebo nightly for 12 weeks. The primary outcomes are feasibility of recruitment, acceptability of intervention and adherence to trial medication at 12 weeks. Secondary outcomes will include the effect of melatonin on brain oxidative stress as measured by magnetic resonance spectroscopy, blood pressure, blood biomarkers, mood, cognition and sleep. Outcomes will be collected at 6 and 12 weeks. The results of this feasibility trial will inform a future conclusive randomised controlled trial to specifically test the efficacy of melatonin on modifiable risk factors of dementia, as well as cognition and brain function. This will be the first trial to investigate the effect of melatonin in the population with MCI in this way, with the future aim of using this approach to reduce progression to dementia.Ethics and disseminationThis protocol has been approved by the Sydney Local Health District Ethics Committee (X18-0077). This randomised controlled trial will be conducted in compliance with the protocol published in the registry, the International Conference for Harmonisation on Good Clinical Practice and all other applicable regulatory requirements. The findings of the trial will be disseminated via conferences, publications and media, as applicable. Participants will be informed of results of the study at the conclusion of the trial. Eligible authors will include investigators who are involved in the conception and design of the study, the conduct of the trial, the analysis of the results, and reporting and presentation of study findings.Trial registration numberAustralian and New Zealand Clinical Trials Registry (ANZCTRN 12619000876190).Protocol versionV.8 15 October 2020.

scholarly journals Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative Stress

2011 ◽  
Vol 30 (2) ◽  
pp. 109-114 ◽  
Author(s):  
Alin Ciobica ◽  
Lucian Hritcu ◽  
Veronica Nastasa ◽  
Manuela Padurariu ◽  
Walther Bild
Keyword(s):  
Oxidative Stress ◽  
Angiotensin Ii ◽  
Angiotensin Converting Enzyme ◽  
Elevated Plus Maze ◽  
Enzyme Inhibitor ◽  
Lipid Peroxidation Product ◽  
Converting Enzyme ◽  
Plus Maze ◽  
Antioxidant Defense Enzymes ◽  
Brain Oxidative Stress

Inhibition of Central Angiotensin Converting Enzyme Exerts Anxiolytic Effects by Decreasing Brain Oxidative StressThis study investigated the effects of angiotensin II and captopril intracerebroventricular administration on anxiety status and brain oxidative stress. Elevated plus maze was used in order to asses the anxiety-like behavior, while the biochemical analysis included the determination of some antioxidant defense enzymes like superoxide dismutase and glutathione peroxidase and also a lipid peroxidation product (malondialdehyde). Our results provide additional evidence of angiotensin II induced anxiety-like effects and increased prooxidant status. Moreover, the blockade of angiotensin II, by the administration of an angiotensin converting enzyme inhibitor (captopril) resulted in anxiolytic effects and decreased oxidative stress status. In addition, we found a significant correlation between the time spent by rats in the open arms of the elevated plus maze and oxidative stress markers. This could raise important therapeutic issues regarding the anxiolytic effects of some angiotensin converting enzyme inhibitors used primarily for hypertension, such as captopril. Also, it seems that oxidative stress could play an important part in these actions.

Quercetin reduces manic-like behavior and brain oxidative stress induced by paradoxical sleep deprivation in mice

2016 ◽  
Vol 99 ◽  
pp. 79-86 ◽  
Author(s):  
Luiz K.S. Kanazawa ◽  
Débora D. Vecchia ◽  
Etiéli M. Wendler ◽  
Palloma de A.S. Hocayen ◽  
Francislaine A. dos Reis Lívero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sleep Deprivation ◽  
Paradoxical Sleep ◽  
Paradoxical Sleep Deprivation ◽  
Brain Oxidative Stress

Arsenosugar Induced Blood and Brain Oxidative Stress, DNA Damage and Neurobehavioral Impairments

2012 ◽  
Vol 38 (2) ◽  
pp. 405-412 ◽  
Author(s):  
Muhammad Shahdaat Bin Sayeed ◽  
Md. Ratan ◽  
Farhad Hossen ◽  
Faizule Hassan ◽  
Mohammad Faisal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Brain Oxidative Stress

Effects of Manganese (Mn) on the Developing Rat Brain: Oxidative-Stress Related Endpoints

2002 ◽  
Vol 23 (2) ◽  
pp. 169-175 ◽  
Author(s):  
Sarah Weber ◽  
David C. Dorman ◽  
Lawrence H. Lash ◽  
Keith Erikson ◽  
Kent E. Vrana ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Brain ◽  
Brain Oxidative Stress ◽  
Developing Rat

Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer's disease amyloidosis model

Phytomedicine ◽  
2019 ◽  
Vol 56 ◽  
pp. 57-63 ◽  
Author(s):  
Fatima Zahra Sadiki ◽  
Mostafa El Idrissi ◽  
Oana Cioanca ◽  
Adriana Trifan ◽  
Monica Hancianu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Essential Oil ◽  
Cognitive Deficits ◽  
Tetraclinis Articulata ◽  
Brain Oxidative Stress
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