A Genetic Predisposition Score Associates with Reduced Aerobic Capacity in Response to Acute Normobaric Hypoxia in Lowlanders

2015 ◽  
Vol 16 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Evi Masschelein ◽  
Joke Puype ◽  
Siacia Broos ◽  
Ruud Van Thienen ◽  
Louise Deldicque ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Genetic Predisposition ◽  
Normobaric Hypoxia ◽  
Genetic Predisposition Score

The Genetic Predisposition Score of Seven Obesity-Related Single Nucleotide Polymorphisms Is Associated with Better Metabolic Outcomes after Roux-en-Y Gastric Bypass

2016 ◽  
Vol 9 (5-6) ◽  
pp. 222-230 ◽  
Author(s):  
Carolina Ferreira Nicoletti ◽  
Marcela A. Souza Pinhel ◽  
Bruno Affonso Parenti de Oliveira ◽  
Julio Sergio Marchini ◽  
Wilson Salgado Junior ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Single Nucleotide Polymorphisms ◽  
Genetic Predisposition ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Metabolic Outcomes ◽  
Genetic Predisposition Score

Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people

2016 ◽  
Vol 19 (11) ◽  
pp. 941-945 ◽  
Author(s):  
Lutz Schega ◽  
Beate Peter ◽  
Tanja Brigadski ◽  
Volkmar Leßmann ◽  
Berend Isermann ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Older People ◽  
Aerobic Capacity ◽  
Normobaric Hypoxia ◽  
Intermittent Normobaric Hypoxia

Genetic Predisposition Score for Hand Grip Strength in the General Population

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 581 ◽  
Author(s):  
Martine A.I. Thomis ◽  
An Windelinckx ◽  
Christophe Delecluse ◽  
Johan Lefevre ◽  
Gaston Beunen
Keyword(s):  
General Population ◽  
Grip Strength ◽  
Genetic Predisposition ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Genetic Predisposition Score

Abstract 004: Physical Activity, Television Watching and Genetic Predisposition in Relation to Body Mass Index in Women and Men

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Qibin Qi ◽  
Yanping Li ◽  
Andrea K Chomistek ◽  
Jae Hee Kang ◽  
Gary C Curhan ◽  
...  
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Body Mass ◽  
Genetic Predisposition ◽  
Leisure Time ◽  
Leisure Time Physical Activity ◽  
Brisk Walking ◽  
Main Effect ◽  
Genetic Predisposition Score ◽  
Tv Watching

Background Previous studies on gene-lifestyle interaction and obesity have largely focused on a single locus, the FTO gene, and overall physical activity, while little attention has been given in the association for sedentary activity as indicated by television (TV) watching. We examined the interactions between leisure-time physical activity and TV watching and the genetic predisposition to increased body mass index (BMI). Methods Longitudinal data were obtained from 7740 women and 4564 men from 2 prospective cohorts: the Nurses’ Health Study and Health Professionals Follow-up Study. Data on physical activity and TV watching were collected 2 years prior to assessment of BMI. A genetic predisposition score was calculated on basis of 32 established BMI-predisposing variants. Results Overall, each additional BMI-increasing allele was associated with an increase of 0.13 (SE 0.01) kg/m 2 in BMI. The effect size for BMI in individuals in the highest physical activity quintile was attenuated compared to that in individuals in the lowest physical activity quintile (0.08 [0.02] vs 0.15 [0.02] kg/m 2 ; P for interaction <0.001). In contrast, the genetic effect on BMI was more pronounced in individuals who spent >40 h/wk of TV watching than that in individuals who spent 0-1 h/wk of TV watching (0.34 [0.10] vs 0.08 [0.04] kg/m 2 ; P for interaction =0.001). Each 4 Mets/d increment in physical activity (equivalents to 1h/d of brisk walking) was associated with a 0.06 (95% CI 0.03-0.08) kg/m 2 reduction in BMI (∼46% of the main effect of each additional BMI-increasing allele), while each 2 h/d increment in TV watching was associated with a 0.03 (0.01-0.06) kg/m 2 increase in BMI (∼23% of the main effect). We estimated that the difference in BMI (∼4.0 kg/m 2 , equivalents to 11.6 kg in body weight for a person 1.70 m tall) between individuals with a genetic predisposition score of 13 (minimum) and those with a score of 43(maximum) could be reduced by half (2.1 kg/m 2 , 6.1 kg in weight) by 1 h/d of brisk walking or increased by 25% (5.0 kg/m 2 , 14.5 kg in weight) by 2h/d of TV watching. Conclusions Greater leisure-time physical activity attenuates the genetic predisposition to increased BMI, whereas sedentary lifestyle indicated by prolonged TV watching accentuates the genetic effects on BMI. Our data suggest that both increasing exercise levels and reducing sedentary behaviors, especially TV watching, independently may mitigate the genetic predisposition to increased BMI.

scholarly journals Diabetes Genetic Predisposition Score and Cardiovascular Complications Among Patients With Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 737-739 ◽  
Author(s):  
Q. Qi ◽  
J. B. Meigs ◽  
K. M. Rexrode ◽  
F. B. Hu ◽  
L. Qi
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Predisposition ◽  
Cardiovascular Complications ◽  
Genetic Predisposition Score

scholarly journals A genetic predisposition score for muscular endophenotypes predicts the increase in aerobic power after training: the CAREGENE study

BMC Genetics ◽  
2011 ◽  
Vol 12 (1) ◽  
pp. 84 ◽  
Author(s):  
Tom Thomaes ◽  
Martine Thomis ◽  
Steven Onkelinx ◽  
Robert Fagard ◽  
Gert Matthijs ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Aerobic Power ◽  
Genetic Predisposition Score

scholarly journals Genetic predisposition score predicts the increases of knee strength and muscle mass after one-year exercise in healthy elderly

2018 ◽  
Vol 111 ◽  
pp. 17-26 ◽  
Author(s):  
Lingxiao He ◽  
Evelien Van Roie ◽  
An Bogaerts ◽  
Christopher I. Morse ◽  
Christophe Delecluse ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Genetic Predisposition ◽  
Healthy Elderly ◽  
Knee Strength ◽  
Genetic Predisposition Score ◽  
One Year

Evaluation of gene–obesity interaction effects on cholesterol levels: A genetic predisposition score on HDL-cholesterol is modified by obesity

2012 ◽  
Vol 225 (2) ◽  
pp. 363-369 ◽  
Author(s):  
Claudia Lamina ◽  
Lukas Forer ◽  
Sebastian Schönherr ◽  
Barbara Kollerits ◽  
Janina S. Ried ◽  
...  
Keyword(s):  
Genetic Predisposition ◽  
Hdl Cholesterol ◽  
Interaction Effects ◽  
Cholesterol Levels ◽  
Genetic Predisposition Score
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