Chronic Intermittent High Altitude Exposure, Occupation, and Body Mass Index in Workers of Mining Industry

2014 ◽  
Vol 15 (3) ◽  
pp. 412-417 ◽  
Author(s):  
Marina K. Esenamanova ◽  
Firuza A. Kochkorova ◽  
Tatyana A. Tsivinskaya ◽  
Denis Vinnikov ◽  
Kairgeldy Aikimbaev
BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e044228
Author(s):  
Henry Oliveros ◽  
Rafael Lobelo ◽  
Luis Fernando Giraldo-Cadavid ◽  
Alirio Bastidas ◽  
Constanza Ballesteros ◽  
...  

ObjectivesObstructive sleep apnoea (OSA)/hypopnoea syndrome is associated with serious and major multiorgan morbidities, particularly in its most severe forms. However, no severe OSA screening instruments are available for high altitude residents that enable adequate identification and clinical prioritisation of such patients. We aimed at developing a severe OSA prediction tool based on the clinical characteristics and anthropometric measurements of a clinical referral cohort living at 2640 m.a.s.l.DesignCohort-nested cross-sectional study.SettingSleep laboratory for standard polysomnography (PSG) in Colombia.ParticipantsA predictive model was generated from 8718 participants referred to the PSG laboratory. Results were subsequently validated in a second cohort of 1898 participants.Primary outcomeTo identify clinical and anthropometric variables associated with severe OSA (>30 events/hour) and to include them in a binary logistic regression model.ResultsThe significant variables that were retained with the presence of severe OSA included Body mass index (BMI), Age, Sex, Arterial hypertension and Neck circumference (BASAN). The area under the receiver operating characteristic curvefor the BASAN index was 0.69 (95% CI: 0.68 to 0.70) in the derivation cohort and 0.67 (95% CI: 0.65 to 0.69) in the validation cohort, whereby a BASAN index ≥2 had a sensitivity of 95% and a specificity of 17% to detect severe OSA.ConclusionAn objectively based approach to screen for the presence of severe OSA, the BASAN index, exhibits favourable sensitivity characteristics that should enable its operational use as a screening tool in a Hispanic population with a clinical suspicion of OSA and living at high altitude.


2016 ◽  
Vol 49 (2) ◽  
pp. 1601530 ◽  
Author(s):  
Tsogyal D. Latshang ◽  
Michael Furian ◽  
Sayaka S. Aeschbacher ◽  
Silvia Ulrich ◽  
Batyr Osmonov ◽  
...  

This case–control study evaluates a possible association between high altitude pulmonary hypertension (HAPH) and sleep apnoea in people living at high altitude.Ninety highlanders living at altitudes >2500 m without excessive erythrocytosis and with normal spirometry were studied at 3250 m (Aksay, Kyrgyzstan); 34 healthy lowlanders living below 800 m were studied at 760 m (Bishkek, Kyrgyzstan). Echocardiography, polysomnography and other outcomes were assessed. Thirty-six highlanders with elevated mean pulmonary artery pressure (mPAP) >30 mmHg (31–42 mmHg by echocardiography) were designated as HAPH+. Their data were compared to that of 54 healthy highlanders (HH, mPAP 13–28 mmHg) and 34 healthy lowlanders (LL, mPAP 8–24 mmHg).The HAPH+ group (median age 52 years (interquartile range 47–59) had a higher apnoea–hypopnoea index (AHI) of 33.8 events·h−1(26.9–54.6) and spent a greater percentage of the night-time with an oxygen saturation <90% (T<90; 78% (61–89)) than the HH group (median age 39 years (32–48), AHI 9.0 events·h−1(3.6–16), T<90 33% (10–69)) and the LL group (median age 40 years (30–47), AHI 4.3 events·h−1(1.4–12.6), T<90 0% (0–0)); p<0.007 for AHI and T<90, respectively, in HAPH+versusothers. In highlanders, multivariable regression analysis confirmed an independent association between mPAP and both AHI and T<90, when controlled for age, gender and body mass index.Pulmonary hypertension in highlanders is associated with sleep apnoea and hypoxaemia even when adjusted for age, gender and body mass index, suggesting pathophysiologic interactions between pulmonary haemodynamics and sleep apnoea.


2017 ◽  
Vol 16 (7) ◽  
pp. 557-561
Author(s):  
Daniel Ter Goon ◽  
Vincent Oladele Adeniyi ◽  
Simon Wuhe Akusu ◽  
Benjamin Ijuo Ejeh ◽  
Unogwu, O. Unogwu

2021 ◽  
Vol 2 (3) ◽  
pp. 425-431 ◽  
Author(s):  
Mostafa A. Abolfotouh ◽  
Naser E. Bilal ◽  
Ibrahim A. Badawl

Thistudy was designed to estimate the carrier rate of beta-haemolytic streptococci among 972 primary-school boys in a high-altitude area of Saudi Arabia, and its association with social class, crowding index and body mass index, and also to determine the seasonal variation of infection. A carrier rate of 13.1% for beta-haemolytic streptococci was detected. The carrier rate was significantly higher in spring than in winter. The association between streptococcal infection and social class, crowding index, or body mass index was statistically not significant. The low prevalence of streptococcal infection might be attributed to the high altitude but further studies are needed to determine whether this is the case


2006 ◽  
Vol 7 (3) ◽  
pp. 245-255 ◽  
Author(s):  
Salim Mohanna ◽  
Rossana Baracco ◽  
Segundo Seclén

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