Angiotensin-Converting Enzyme Genotype and Successful Ascent to Extreme High Altitude

2007 ◽  
Vol 8 (4) ◽  
pp. 278-285 ◽  
Author(s):  
Julian Thompson ◽  
James Raitt ◽  
Lynn Hutchings ◽  
Fotios Drenos ◽  
Eirik Bjargo ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Altitude ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Genotype

scholarly journals Angiotensin-Converting Enzyme Genotype and Arterial Oxygen Saturation at High Altitude in Peruvian Quechua

2008 ◽  
Vol 9 (2) ◽  
pp. 167-178 ◽  
Author(s):  
Abigail W. Bigham ◽  
Melisa Kiyamu ◽  
Fabiola León-Velarde ◽  
Esteban J. Parra ◽  
Maria Rivera-Ch ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Oxygen Saturation ◽  
High Altitude ◽  
Arterial Oxygen Saturation ◽  
Arterial Oxygen ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Genotype

scholarly journals Angiotensin converting enzyme insertion allele in relation to high altitude adaptation

2001 ◽  
Vol 65 (6) ◽  
pp. 531-536 ◽  
Author(s):  
M. A. QADAR PASHA ◽  
A. P. KHAN ◽  
R. KUMAR ◽  
S. K. GROVER ◽  
R. B. RAM ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Altitude ◽  
Converting Enzyme ◽  
High Altitude Adaptation ◽  
Altitude Adaptation ◽  
Insertion Allele

Association of high-altitude systemic hypertension with the deletion allele-of the angiotensin-converting enzyme (ACE) gene

2003 ◽  
Vol 48 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Ratan Kumar ◽  
M. A. Qadar Pasha ◽  
Amjad P. Khan ◽  
V. Gupta ◽  
S. K. Grover ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
High Altitude ◽  
Systemic Hypertension ◽  
Converting Enzyme ◽  
Deletion Allele ◽  
Ace Gene

No Relation between Angiotensin-Converting Enzyme Gene Polymorphism and Dermal Responses to Bradykinin in Healthy Subjects

1996 ◽  
Vol 91 (5) ◽  
pp. 617-620 ◽  
Author(s):  
I. G. Chadwick ◽  
M. Kraskiewicz ◽  
W. W. Yeo ◽  
K. S. Higgins ◽  
P. R. Jackson ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Gene Polymorphism ◽  
Angiotensin Converting Enzyme ◽  
Healthy Subjects ◽  
Angiotensin Converting Enzyme Gene ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity ◽  
Serum Angiotensin Converting Enzyme ◽  
Enzyme Gene ◽  
Angiotensin Converting Enzyme Genotype

1. The dermal wheal response to bradykinin is increased by drugs which inhibit angiotensin-converting enzyme, and thus provides a measure of angiotensin-converting enzyme activity at the tissue level. An insertion/deletion polymorphism of the angiotensin-converting enzyme gene predicts serum angiotensin-converting enzyme activity, but its relation to angiotensin-converting enzyme activity in tissue is unclear. 2. The relations between angiotensin-converting enzyme genotype and wheal responses to intradermal bradykinin were studied in 105 healthy subjects: 30 of genotype DD, 51 of genotype ID and 24 of genotype II. Dermal wheal area was measured by digitized planimetry and the angiotensin-converting enzyme genotype by polymerase chain reaction. 3. Bradykinin produced significant linear log dose—wheal area responses. The potency of bradykinin by parallel line bioassay did not differ significantly between the genotypes; the potency in the II subjects relative to DD subjects was 1.25 (95% confidence interval: 0.83–1.88). 4. Although the angiotensin-converting enzyme gene polymorphism is a consistent and powerful predictor of serum angiotensin-converting enzyme activity, it does not appear to predict tissue angiotensin-converting enzyme activity as measured by dermal responses to bradykinin.

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