Pathogenesis of High Altitude Pulmonary Edema: Does Alveolar Epithelial Lining Fluid Vascular Endothelial Growth Factor Exacerbate Capillary Leak?

2004 ◽  
Vol 5 (4) ◽  
pp. 399-409 ◽  
Author(s):  
Robert J. Kaner ◽  
Ronald G. Crystal
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Pulmonary Edema ◽  
Vascular Endothelial ◽  
Epithelial Lining ◽  
Capillary Leak ◽  
Epithelial Lining Fluid ◽  
Alveolar Epithelial ◽  
High Altitude Pulmonary Edema ◽  
Endothelial Growth Factor

Opposing Effects of Isoflurane and Sevoflurane on Neurogenic Pulmonary Edema Development in an Animal Model

2005 ◽  
Vol 102 (6) ◽  
pp. 1182-1189 ◽  
Author(s):  
Nobuhisa Kandatsu ◽  
Yong-Shan Nan ◽  
Guo-Gang Feng ◽  
Kimitoshi Nishiwaki ◽  
Mitsuru Hirokawa ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Animal Model ◽  
Growth Factor ◽  
Pulmonary Edema ◽  
Neurogenic Pulmonary Edema ◽  
Vascular Endothelial ◽  
Lung Water ◽  
Index Of Severity ◽  
Opposing Effects ◽  
Endothelial Growth Factor

Background The current study was undertaken to investigate the effects of pretreatment with isoflurane and sevoflurane on the development of neurogenic pulmonary edema in an animal model. Methods Rats were exposed to room air (control), 1.5% isoflurane, or 2.5% sevoflurane for 4 h. They were then anesthetized with intraperitoneal injections of pentobarbital sodium, and fibrinogen and thrombin were injected into the cisterna magna to induce neurogenic pulmonary edema. Results Consecutive injections of fibrinogen and thrombin caused increases in blood pressure, with the peak values obtained in the isoflurane and sevoflurane groups being lower than the control values. The incidence of significant neurogenic pulmonary edema was 58%, 100%, and 8% in the control, isoflurane, and sevoflurane groups, respectively. The lung water ratio, an index of severity of edema, was 4.86 +/- 0.78, 6.15 +/- 0.64, and 4.40 +/- 0.32 in the control, isoflurane, and sevoflurane groups, respectively. Furthermore, immunohistochemical staining for vascular endothelial growth factor demonstrated an increase of expression in the rat lungs exposed to isoflurane. Treatment with an anti-vascular endothelial growth factor antibody during exposure to isoflurane completely inhibited the effect of isoflurane to promote neurogenic pulmonary edema in this model. Conclusion Exposure to 1.5% isoflurane enhances the development of neurogenic pulmonary edema development in this animal model, most likely via release of vascular endothelial growth factor from bronchial epithelial cells, an effect not observed with sevoflurane.

scholarly journals Lung Overexpression of the Vascular Endothelial Growth Factor Gene Induces Pulmonary Edema

2000 ◽  
Vol 22 (6) ◽  
pp. 657-664 ◽  
Author(s):  
Robert J. Kaner ◽  
John V. Ladetto ◽  
Ravi Singh ◽  
Norimasa Fukuda ◽  
Michael A. Matthay ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Pulmonary Edema ◽  
Vascular Endothelial ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Endothelial Growth Factor
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