Development of a Low Malignant Potential Ovarian Mucinous Cystadenoma After Ovulation Induction with Clomiphene Citrate: The Role of Conservative Surgery

1998 ◽  
Vol 14 (1) ◽  
pp. 27-29
Author(s):  
SHAWKY Z.A. BADAWY ◽  
LOREN FRANKEL
Keyword(s):  
Ovulation Induction ◽  
Clomiphene Citrate ◽  
Mucinous Cystadenoma ◽  
Conservative Surgery ◽  
Malignant Potential ◽  
Low Malignant Potential

scholarly journals Oncologic and Reproductive Results in Conservative Surgery for Ovarian Low Malignant Potential Tumours

2010 ◽  
Vol 17 (6) ◽  
pp. S172
Author(s):  
M.J. Martinez-Serrano ◽  
C. Siso ◽  
I. Gonzalez-Foruria ◽  
P. Fuste ◽  
S. Martinez-Roman ◽  
...  
Keyword(s):  
Conservative Surgery ◽  
Malignant Potential ◽  
Low Malignant Potential

scholarly journals PSEUDO PAPILLARY TUMOUR OF PANCREAS

2009 ◽  
Vol 16 (04) ◽  
pp. 609-610
Author(s):  
QURATULAIN SOOMRO ◽  
Hafeez Soomro ◽  
KHAN MUHAMMAD ◽  
Sardar Khatoon ◽  
ABDUL SAMAD SHAIKH ◽  
...  
Keyword(s):  
Excisional Biopsy ◽  
Malignant Potential ◽  
Definitive Treatment ◽  
Low Grade ◽  
Young Females ◽  
Invasive Tumour ◽  
Papillary Tumour ◽  
Pancreatic Tumour ◽  
Low Malignant Potential

During 05 years period from January 2003 to December 2007,45 cases of Ca. Pancreas were reported to LINAR and only onecase of Pseudo Papillary Tumour of Pancreas is registered. It is a rare, low malignant potential pancreatic tumour. It has unknown pathogenesisand found in young females. We report a case of 24 years old female, who presented with pain in abdomen and low grade fever of 07 monthsduration. Lepratomy and excisional biopsy was done. H/P came as Pseudo Papillary Tumour of Pancreas. At presentation no any L.N. werefound enlarged. Like other malignant pancreatic tumours, this neoplasm does not metastasize. Its definitive treatment is complete surgicalremoval, no any role of chemotherapy because it doesn't metastasized, limited role of radiotherapy in local invasive tumour or in residual mass.

Role of aromatase inhibitor in ovulation induction in patients with poor response to clomiphene citrate

2006 ◽  
Vol 32 (5) ◽  
pp. 502-506 ◽  
Author(s):  
Mosammat R. Begum ◽  
Ehsan Quadir ◽  
Anowara Begum ◽  
Rowsan A. Begum ◽  
Momtaz Begum
Keyword(s):  
Aromatase Inhibitor ◽  
Ovulation Induction ◽  
Clomiphene Citrate ◽  
Poor Response

scholarly journals The Continuum of Serous Tumors of Low Malignant Potential and Low-Grade Serous Carcinomas of the Ovary

2007 ◽  
Vol 23 (5-6) ◽  
pp. 377-387 ◽  
Author(s):  
Kwong-Kwok Wong ◽  
David Gershenson
Keyword(s):  
Malignant Potential ◽  
Low Grade ◽  
Epithelial Cancer ◽  
Clinical Genetic ◽  
Ovarian Carcinomas ◽  
Low Malignant Potential ◽  
Serous Tumors ◽  
The Continuum

The role of serous tumors of low malignant potential (LMP) in the development of invasive epithelial cancer of the ovary is debatable. This review summarizes the current clinical, genetic, and genomic evidence for the existence of a continuum comprising both LMP serous tumors and low-grade serous ovarian carcinomas.

Operative staging and conservative surgery in the management of low malignant potential ovarian tumors

1992 ◽  
Vol 2 (3) ◽  
pp. 113-118 ◽  
Author(s):  
W. R. Robinson ◽  
J. P. Curtin ◽  
C. P. Morrow
Keyword(s):  
Ovarian Tumor ◽  
Malignant Tumors ◽  
Frozen Section ◽  
Conservative Surgery ◽  
Malignant Potential ◽  
Factors Affecting ◽  
Surgery Patient ◽  
Intraoperative Management ◽  
Low Malignant Potential ◽  
Histopathologic Findings

The medical records of 45- patients with intraoperative diagnosis of borderline or low malignant potential (LMP) ovarian tumor were reviewed to identify factors affecting intraoperative management. The correlation between gross and histologic staging was examined, as was the complication rate following surgery. Patient age and presence of qualifying pathologic terms on frozen section diagnosis were the only important factors relating to performance of surgical procedure. Surgical complications were closely associated with non-conservative surgery. Thirteen of 14 (92.8%) patients with significant complications had a hysterectomy. These 14 patients had staging procedures at essentially the same rate as the entire population. Thirteen of 45 patients (28.8%) thought to have LMP by frozen section had a different diagnosis on permanent review; 5 were benign and 8 were frankly malignant, confirming the limitations of frozen section in the diagnosis of LMP ovarian tumor. Of 40 with LMP or frankly malignant tumors 5(12.5%) were upstaged based on unsuspected histopathologic findings. These results indicate the need for a standard approach to staging in patients who are suspected to have an LMP ovarian tumor and should encourage the performance of conservative surgery when appropriate.

Giant ovarian cysts: Is a pre- and intraoperative drainage an advisable procedure?

2006 ◽  
Vol 16 (6) ◽  
pp. 2039-2043 ◽  
Author(s):  
J. Einenkel ◽  
H. Alexander ◽  
D. Schotte ◽  
P. Stumpp ◽  
L.-C. Horn
Keyword(s):  
Critical Evaluation ◽  
Mucinous Cystadenoma ◽  
Malignant Potential ◽  
Ovarian Cysts ◽  
The Past ◽  
Considerable Debate ◽  
Low Malignant Potential ◽  
Definitive Surgery

There has been a considerable debate over the merits of a pre- or intraoperative drainage of giant ovarian cysts, which represented a very frequent approach before definitive surgery in the past. Including our presented case of a 57-year-old woman with a 49 kg mucinous cystadenoma, 19 patients with giant ovarian cysts weighing more than 40 kg were reported in the literature since 1970. An incidence of 37% of malignant and low malignant potential tumors was found. Based on a critical evaluation of the medical courses and the discussed miscellaneous advantages and complications, we conclude that a pre- and intraoperative drainage should be avoided.

scholarly journals Letrozole: an emerging array of hope for infertile women

2020 ◽  
Vol 9 (2) ◽  
pp. 891
Author(s):  
Manish Maladkar ◽  
Chitra Tekchandani ◽  
Akshata Karchodi
Keyword(s):  
Live Birth ◽  
Ovulation Induction ◽  
Polycystic Ovary ◽  
Clomiphene Citrate ◽  
Unexplained Infertility ◽  
Birth Rates ◽  
Live Birth Rates ◽  
First Line Therapy ◽  
Estrogenic Action

Ovulation induction has been a major breakthrough in the management of female infertility since many decades. Letrozole, an aromatase inhibitor has been used as a potential therapy for ovulation induction. A large number of clinical evidences have been emerging which cite the beneficial role of Letrozole in conditions like anovulatory infertility, polycystic ovary syndrome (PCOS), unexplained infertility and an incipient role in endometriosis- related infertility with regards to higher live-birth rates. Letrozole is a superior alternative to Clomiphene citrate (CC) which has been used conventionally as ovulation inducer. Clomiphene citrate has certain well-defined disadvantages, whereas Letrozole overcomes these limitations to a reasonable extent. The peripheral anti-estrogenic effect of CC leads to prolonged depletion of estrogens receptors, adversely affecting endometrial growth and development as well as quantity and quality of cervical mucus. Persistent blockade of estrogen receptor leads to CC resistance and is associated with reduced ovulation and pregnancy rates. Available evidences suggest Letrozole is superior to CC owing to the lack of persistent anti-estrogenic action due to its short half- life and lack of action on estrogen receptors. This typically leads to monofollicular growth and also higher live birth rates. The current evidences suggest that Letrozole can be placed as first line therapy for the management of infertility due to PCOS and unexplained infertility.

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