Interleukin 6 (IL-6) and IL-10 Promoter Region Polymorphisms Are Associated with Risk of Lumbar Disc Herniation in a Northern Chinese Han Population

2017 ◽  
Vol 21 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Xiangye Huang ◽  
Feng Chen ◽  
Jing Zhao ◽  
Dezhang Wang ◽  
Shenfeng Jing ◽  
...  
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Interleukin 6 ◽  
Promoter Region ◽  
Lumbar Disc ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Northern Chinese

scholarly journals PTPN9 Genes Polymorphism as a Protect Factor in Lumbar Disc Herniation Development

2021 ◽  
Author(s):  
Dandan Li ◽  
Huqiang Mai ◽  
Yuhe Wang ◽  
Li Wang ◽  
Xiaoli Liu ◽  
...  
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Additive Model ◽  
Chinese Han Population ◽  
Protective Effects ◽  
Chinese Han ◽  
Gender Stratification ◽  
Han Population ◽  
The Impact

Abstract Background: Lumbar disc herniation (LDH) is a high incidence spinal disease caused by disc degeneration, nuclear pulse displacement or fiber ring degeneration. This study aimed to explore the correlation between PTPN9 susceptibility and lumbar disc herniation in Chinese Han population.Methods: The subjects were 504 patients with lumbar disc hernia and 503 controls. PTPN9 polymorphism (rs76107647, rs10851882, rs753992, rs11072552) are genotype using Agena MassArray. In addition, Logistic regression was used for odds ratios (ORs) and 95% confidence intervals (CIs) to assess the impact of genetic polymorphisms on LDH occurrence.Results: In the allele model, rs76107647 A (p = 0.023) is associated with a reduced risk of LDH . In the analysis of genetic models, we found that rs76107647 (adjusted, A/A vs. G/G: p = 0.035; A/A vs. AG/GG: p = 0.044; log - additive model: p = 0.022, respectively) and rs11072552 (adjusted, C/C vs. A/A: p = 0.048; C/C vs. CA/AA: p = 0.010, respectively)were significantly related to LDH risk reduction. After age stratification, rs76107647（adjusted, A/A vs. G/G: p = 0.036; A/G vs. G/G: p = 0.008, ; AA/AG vs. G/G: p = 0.002; log–additive model: p = 0.001, respectively) can reduce the risk of LDH for young people ≤ 49 years old, while rs11072552 (adjusted, CC vs. CA/AA: p = 0.009) can significantly reduce the risk of LDH in patients over 49 years old. With gender stratification, rs76107647 (adjusted, A/A vs. G/G: p = 0.017, ; A/A vs. AG/GG: p = 0.019; log - additive model: p = 0.018, respectively) was significantly associated with reduced LDH risk in female. Conclusion: Our research suggests that PTPN9 polymorphisms may have protective effects on the risk of LDH in Chinese Han population.

scholarly journals IL1R1 Polymorphisms are Associated with Lumbar Disc Herniation Risk in the Northwestern Chinese Han Population

2019 ◽  
Vol 25 ◽  
pp. 3728-3738 ◽  
Author(s):  
Yong Zhu ◽  
Shunan Li ◽  
Yao Sun ◽  
Jiamin Wu ◽  
Zichao Xiong ◽  
...  
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

Association of GSDMC polymorphisms with lumbar disc herniation among Chinese Han population

2020 ◽  
Vol 47 (6) ◽  
pp. 546-553
Author(s):  
Jiamin Wu ◽  
Yao Sun ◽  
Zichao Xiong ◽  
Jianfeng Liu ◽  
Haiyue Li ◽  
...  
Keyword(s):  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population
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